Correlation of motor function and respiratory individuals with Duchenne muscular dystrophy

Authors

DOI:

https://doi.org/10.33448/rsd-v11i9.30701

Keywords:

Muscular dystrophy Duchenne; Physical therapy specialty; Respiratory Function Tests.

Abstract

Since the gradual weakness of the respiratory muscles, especially the diaphragm, induces respiratory complications, monitoring the lung function of people with Duchenne Muscular Dystrophy (DMD) is essential. It is noteworthy that this deficiency in the respiratory system is the leading cause of death in patients with DMD. The objective was to correlate the motor and respiratory function of individuals with DMD. 14 individuals were evaluated, 09 being subdivided in the study group and 05 in the control group; all male, aged 11.3 (± 0.5) years, were evaluated using the scales for measuring motor function (MFM), Elgen Klassifikation (EK) and spirometry and manovacuometry tests. The MFM, EK, spirometry and manovacuometry variables were analyzed using the t-student test (p<0.05). Significant values were considered between motor function and spirometric variables and respiratory pressures analyzed using the Pearson correlation index. A significant reduction in motor function and greater functional dependence has been demonstrated in individuals with DMD. Spirometric and manovacuometric evaluations showed a reduction in lung function, and the correlations were significant, showing a strong relationship between the decline in motor function concomitant with lung function. The results of this study indicate that the impairment of motor function predicts the intensity of respiratory changes. It can be concluded that, in individuals with DMD, motor and respiratory function are reduced with advancing age; and that functional performance and respiratory conditions are directly associated. It is suggested that respiratory treatment should be combined with functional performance treatment.

Author Biographies

Diogo Costa Garção, Universidade Federal de Sergipe

Fisioterapeuta

Poliana Andrade, Universidade Federal de Sergipe

Fisioterapeuta - UFS

Tatiane de Oliveira Santos, Universidade Federal de Sergipe

Enfermeira - UNIT

Mestranda - UFS

Raquel Prado da Silva, Universidade Federal de Sergipe

Enfermeira - UNIT

Mestranda - UFS

Jeison Saturnino de Oliveira, Universidade Federal de Sergipe

Professor Associado (Departamento de Morfologia) - UFS

References

Andrews, J. G., Soim, A., Pandya, S., Westfield, C. P., Ciafaloni, E., Fox, D. J.(2016). Respiratory Care Received by Individuals With Duchenne Muscular Dystrophy From 2000 to 2011. Respiratory Care, v. 61, n. 10, p. 1349-1359.

Angliss, M. E.; Sclip, K. D.; Gauld, L. (2020). Early NIV is associated with accelerated lung function decline in Duchenne muscular dystrophy treated with glucocorticosteroids. BMJ open respiratory research, 7(1), e000517.

Brogna, C.; Cristiano, L.; Verdolotti, T.; Norcia, G.; Ficociello, L.; Ruiz, R.; Mercuri, E. (2021). Longitudinal Motor Functional Outcomes and Magnetic Resonance Imaging Patterns of Muscle Involvement in Upper Limbs in Duchenne Muscular Dystrophy. Medicina, 57(11), 1267.

Carvalhais, M. B. (2020). Miopatia Nemalínica: Caracterização da função pulmonar, motora e escores de qualidade de vida. Dissertação (Mestrado em Saúde da Criança e do Adolescente) - Universidade Federal de Minas Gerais, Belo Horizonte, 2020. Disponível em: https://repositorio.ufmg.br/handle/1843/35983. Acesso em: 15 dez. 2021.

Chew, K., Carey, K., Ho, G., Mallitt, K. A., Widger, J., & Farrar, M. (2016). The relationship of body habitus and respiratory function in Duchenne muscular dystrophy. Respiratory Medicine, v. 119, p. 35-40.

Eduardo, I. M., Oliveir;, L. C. D., Ribeiro; M. F. M.; Prudente, C. O. M. (2021). Sobrecarga de cuidadores de pacientes com Distrofia Muscular de Duchenne: relação com a capacidade funcional. Rev. Pesqui.(Univ. Fed. Estado Rio J., Online), 547-552.

Fagoaga, J.; Girabent-Farrés, M.; Bagur-Calafat, C.; Febrer, A.; Steffensen, B. F. (2015). Evaluación funcional para personas no ambulantes afectas de atrofia muscular espinal y distrofia muscular de Duchenne. Traducción y validación de la escala Egen Klassifikation 2 para la población española. Rev Neurol, 60, 439-446.

Ferreira, M. S.; Mendes, R. T.; Marson, F. A.; Zambon, M. P.; Antonio, M. A.; Paschoal, I. A.; Ribeiro, J. D. (2017). Espirometria e capnografia volumétrica na avaliação da função pulmonar de indivíduos obesos e eutróficos sem asma. Jornal de Pediatria, 93, 398-405.

Gogou, M.; Pavlou, E.; Haidopoulou, K. (2020). Therapies that are available and under development for Duchenne muscular dystrophy: What about lung function?. Pediatric pulmonology, 55(2), 300-315.

Komatsu, A. V. (2017). Comparação dos poderes dos testes t de student e Man-Whitney Wilcoxon pelo método de Monte Carlo. Revista da Estatística da Universidade Federal de Ouro Preto, 6.

Lee, H. N., Sawnani, H., Horn, P. S., Rybalsky, I., Relucio, L., & Wong, B. L.(2016). The Performance of the Upper Limb scores correlate with pulmonary function test measures and Egen Klassifikation scores in Duchenne muscular dystrophy. Neuromuscular Disorders, v. 26, n. 4, p. 264-271.

Lee, J. W.; Cho, H. E.; Kang, S. W.; Choi, W. A.; Suh, M. R.; Kim, B. (2021). Correlation of Bone Mineral Density with Pulmonary Function in Advanced Duchenne Muscular Dystrophy. PM&R, 13(2), 166-170.

Maciel, F. K. D. L.; Santos, A. L. Y. D. S.; Artilheiro, M. C., Sá; C. D. S. C. D. (2021). Motor Compensation Strategies for Reduced Upper Limb Function Among Individuals With Duchenne Muscular Dystrophy. Perceptual and Motor Skills, 128(3), 1059-1077.

Meier, T., Rummey, C., Leinonen, M., Spagnolo, P., Mayer, O. H., Buyse, G. M.,& Richardson, R. C.(2017). Study group: characterization of pulmonary function in 10-18 year-old patients with Duchenne muscular dystrophy. Neuromuscular Disorders, v. 27, p. 307-314. DOI 10.1016/j.nmd.2016.12.014.

Ryan, L.; Rahman, T.; Strang, A.; Heinle, R.; Shaffer, T. H. (2020). Diagnostic differences in respiratory breathing patterns and work of breathing indices in children with Duchenne muscular dystrophy. Plos one, 15(1), e0226980.

Rodrigues, M. V.; Oliveira, M. C. S.;, Silva, T. D. D.; Ferreira, C.; Valente, H. B.; Vanzella, L. M.; Vanderlei, L. C. M. (2021). Autonomic modulation at rest and in response to postural change in adolescents with Duchenne muscular dystrophy: a cross-sectional study. Arquivos de Neuro-Psiquiatria, 79, 766-773.

Sá, C. D. S. C. D.; Fagundes, I. K.; Araújo, T. B.; Oliveira, A. S. B.; Fávero, F. M. (2016). The relevance of trunk evaluation in Duchenne muscular dystrophy: the segmental assessment of trunk control. Arquivos de neuro-psiquiatria, 74, 791-795.

Santos, R. B.; Maia, A. B. F.;, Lanzillotta, P.; Ferreira, L. R. N. B.; Olmo, J. P. V.; Alcantara, K. A. (2019). Avaliação Respiratória e Elaboração de um Protocolo de Tratamento para um paciente com Distrofia Muscular de Duchenne. Relato de caso. UNILUS Ensino e Pesquisa, 16(43), 168-177.

Published

11/07/2022

How to Cite

GARÇÃO, D. C. .; ANDRADE, P. .; SANTOS, T. de O. .; SILVA, R. P. da .; SANTOS, V. F. dos .; DÉDA, A. V. .; NASCIMENTO , J. .; OLIVEIRA, J. S. de .; FRAGA, B. P. .; MOREIRA, O. S. M. . Correlation of motor function and respiratory individuals with Duchenne muscular dystrophy. Research, Society and Development, [S. l.], v. 11, n. 9, p. e32411930701, 2022. DOI: 10.33448/rsd-v11i9.30701. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/30701. Acesso em: 22 nov. 2024.

Issue

Section

Health Sciences