Effect of antibiotic therapy in the postoperative period of third molar surgeries: a split-mouth, randomized and controlled study
DOI:
https://doi.org/10.33448/rsd-v11i8.31236Keywords:
Molar third; Surgery oral; Edema; Trismus.Abstract
Purpose: The objective of this randomized clinical trial was to evaluate the postoperative period of 32 third molars, semi-included or included, in a split mouth, of patients from the São Paulo State University. Material and Methods: The teeth were divided into two groups, in the test group drug treatment with Amoxicillin 500 mg, Dexamethasone 4 mg and Dipyrone 500 mg and in the control group patients received treatment with Dexamethasone 4 mg and Dipyrone 500 mg. The parameters used were edema, trismus and pain, measured before and after the operation, where the benefits of antibiotic therapy were evaluated. To compare the data, an analog pain scale was used, the method of Ustün, and the millimeter ruler, being submitted to Student's T test. Results: Both test and control groups had similar values, with no statistically significant difference in the incidence of postoperative complications, as well as in the presence of edema, pain and more pronounced trismus between the groups analyzed in the study. Conclusions: In view of the statistical results obtained, it was not possible to state that the use of antibiotic therapy was beneficial when related to edema, trismus and pain.
References
Aravena, P. C., Yatabe, K., Jerez, A., Monardes, H., Groppo, F. C., & Benso, B. (2019). Assessment of the bioavailability of an antibiotic prophylactic protocol in patients undergoing third molar surgery. International Journal of Oral and Maxillofacial Surgery, 48(11), 1470–1474. https://doi.org/10.1016/j.ijom.2019.04.006
Arora, A., Roychoudhury, A., Bhutia, O., Pandey, S., Singh, S., & Das, B. K. (2014). Antibiotics in third molar extraction; are they really necessary: A non-inferiority randomized controlled trial. National Journal of Maxillofacial Surgery, 5(2), 166–171. https://doi.org/10.4103/0975-5950.154821
Bezerra, T. P., Studart-Soares, E. C., Scaparo, H. C., Pita-Neto, I. C., Batista, S. H. B., & Fonteles, C. S. R. (2011). Prophylaxis versus placebo treatment for infective and inflammatory complications of surgical third molar removal: a split-mouth, double-blind, controlled, clinical trial with amoxicillin (500 mg). Journal of Oral and Maxillofacial Surgery: Official Journal of the American Association of Oral and Maxillofacial Surgeons, 69(11), e333-9. https://doi.org/10.1016/j.joms.2011.03.055
Cervino, G., Cicciù, M., Biondi, A., Bocchieri, S., Herford, A. S., Laino, L., & Fiorillo, L. (2019). Antibiotic Prophylaxis on Third Molar Extraction: Systematic Review of Recent Data. Antibiotics (Basel, Switzerland), 8(2). https://doi.org/10.3390/antibiotics8020053
Colombini, B. L., Modena, K. C. S., Calvo, A. M., Sakai, V. T., Giglio, F. P. M., Dionísio, T. J., Trindade, A. S., Lauris, J. R. P., & Santos, C. F. (2006). Articaine and mepivacaine efficacy in postoperative analgesia for lower third molar removal: a double-blind, randomized, crossover study. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, 102(2), 169–174. https://doi.org/10.1016/j.tripleo.2005.09.003
Estrela, C. (2018). Metodologia Científica: Ciência, Ensino e Pesquisa (3a ed.). Artes Médicas, 120-122.
George, R., & Kavyashree, G. (2017). Effect of four mouth rinses on microhardness of esthetic restorative material: An in vitro Study. Journal of International Oral Health, 9(2), 55–59. https://doi.org/10.4103/jioh.jioh_21_16
Izuzquiza, I., Jamtøy, K. A., Fossland, N. P., Martínez-Padilla, I., Falahat, F., Alou, L., Prieto, J., & Gómez-Lus, M. L. (2017). [Is it necessary to prescribe antibiotics in impacted third molar surgical removal?: comparative study between prescribing patterns]. Revista espanola de quimioterapia: publicacion oficial de la Sociedad Espanola de Quimioterapia, 30(1), 34–39.
Karm, M. H., Park, F. D., Kang, M., Kim, H. J., Kang, J. W., Kim, S., Kim, Y. D., Kim, C. H., Seo, K. S., Kwon, K. H., Kim, C. H., Lee, J. W., Hong, S. W., Lim, M. H., Nam, S. K., & Cho, J. M. (2017). Comparison of the efficacy and safety of 2% lidocaine HCl with different epinephrine concentration for local anesthesia in participants undergoing surgical extraction of impacted mandibular third molars. Medicine (United States), 96(21). https://doi.org/10.1097/MD.0000000000006753
Lee, J. Y., Do, H. S., Lim, J. H., Jang, H. S., Rim, J. S., Kwon, J. J., & Lee, E. S. (2014). Correlation of antibiotic prophylaxis and difficulty of extraction with postoperative inflammatory complications in the lower third molar surgery. The British Journal of Oral & Maxillofacial Surgery, 52(1), 54–57. https://doi.org/10.1016/j.bjoms.2013.08.010
López-Cedrún, J. L., Pijoan, J. I., Fernández, S., Santamaria, J., & Hernandez, G. (2011). Efficacy of amoxicillin treatment in preventing postoperative complications in patients undergoing third molar surgery: a prospective, randomized, double-blind controlled study. Journal of Oral and Maxillofacial Surgery: Official Journal of the American Association of Oral and Maxillofacial Surgeons, 69(6), e5-14. https://doi.org/10.1016/j.joms.2011.01.019
Maxwell, C. (1978). Sensitivity and accuracy of the visual analogue scale: a psycho-physical classroom experiment. British Journal of Clinical Pharmacology, 6(1), 15–24. https://doi.org/10.1111/j.1365-2125.1978.tb01676.x
McCarthy, C., Warren, E., & Sleeman, D. (2018). Comparison of anaesthetic regime in patients undergoing third molar extraction. Oral Surgery, 11(1), 33–40. https://doi.org/10.1111/ors.12297
Menon, R. K., Kar Yan, L., Gopinath, D., & Botelho, M. G. (2019). Is there a need for postoperative antibiotics after third molar surgery? A 5-year retrospective study. Journal of Investigative and Clinical Dentistry, 10(4), e12460. https://doi.org/10.1111/jicd.12460
Milani, B. A., Bauer, H. C., Sampaio-Filho, H., Horliana, A. C. R. T., Perez, F. E. G., Tortamano, I. P., & Jorge, W. A. (2015). Antibiotic therapy in fully impacted lower third molar surgery: randomized three-arm, double-blind, controlled trial. Oral and Maxillofacial Surgery, 19(4), 341–346. https://doi.org/10.1007/s10006-015-0521-6
Moher, D., Hopewell, S., Schulz, K. F., Montori, V., Gøtzsche, P. C., Devereaux, P. J., Elbourne, D., Egger, M., & Altman, D. G. (2012). CONSORT 2010 explanation and elaboration: updated guidelines for reporting parallel group randomised trials. International Journal of Surgery (London, England), 10(1), 28–55. https://doi.org/10.1016/j.ijsu.2011.10.001
Pell, G. J., & Gregory, B. T. (1933). Impacted mandibular third molars: classification and modified techniques for removal. Dent Digest, 39, 330-338.
Poeschl, P. W., Eckel, D., & Poeschl, E. (2004). Postoperative prophylactic antibiotic treatment in third molar surgery--a necessity? Journal of Oral and Maxillofacial Surgery: Official Journal of the American Association of Oral and Maxillofacial Surgeons, 62(1), 3–8; discussion 9. https://doi.org/10.1016/j.joms.2003.05.004
Reiland, M. D., Ettinger, K. S., Lohse, C. M., & Viozzi, C. F. (2017). Does Administration of Oral Versus Intravenous Antibiotics for Third Molar Removal Have an Effect on the Incidence of Alveolar Osteitis or Postoperative Surgical Site Infections? Journal of Oral and Maxillofacial Surgery: Official Journal of the American Association of Oral and Maxillofacial Surgeons, 75(9), 1801–1808. https://doi.org/10.1016/j.joms.2017.03.038
Ustün, Y., Erdogan, O., Esen, E., & Karsli, E. D. (2003). Comparison of the effects of 2 doses of methylprednisolone on pain, swelling, and trismus after third molar surgery. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, 96(5), 535–539. https://doi.org/10.1016/S1079210403004645
Winter, G. B. (1926). Principles of exodontia as applied to the impacted mandibular third molar: A complete treatise on the operative technic with clinical diagnoses and radiographic interpretations. St. Louis, Mo: American medical Book Company.
Yoshida, H., Matsuda, S., Aratani, T., Tsukamoto, H., Yoshimura, H., Sano, K., & Iwasaki, H. (2020). Collaboration with an infection control team promoted appropriate antibiotic use for third molar extraction at a Japanese hospital. Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy, 26(6), 531–534. https://doi.org/10.1016/j.jiac.2020.01.003
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