COVID-19, dyslipidemia and familial hypercholesterolemia: an up-date

Authors

DOI:

https://doi.org/10.33448/rsd-v11i9.31975

Keywords:

Dyslipidemia; Familial Hypercholesterolemia; COVID-19; SARS-CoV-2; Hypolipidemic.

Abstract

COVID-19 (coronavirus disease 2019) is an infection caused by the SARS-CoV-2 coronavirus, which can evolve into a severe respiratory condition, affecting the world population in a pandemic manner. In this study, we aimed to update the findings of the mechanisms that associate dyslipidemia with COVID-19 infection, the evolution of severe form and the influence of lipid-lowering treatment on outcomes. The search was performed in the PubMed and Embase databases and the selection was based on dyslipidemia and COVID-19 studies, which resulted in 31 articles. In results, the evidence in changes in cholesterol metabolism was found in SARS-CoV-2 virus infection with variations in high-density lipoprotein (HDL) levels. In addition, it provided an increase in triglycerides (TG) and very-low-density lipoprotein cholesterol (VLDLc). Patients with familial hypercholesterolemia (FH) with COVID-19 representing a group of individuals who develop early atherosclerotic disease with a higher risk of cardiovascular event, which should intensify the lipid-lowering treatment due to the potential risk of coronary endothelial dysfunction caused by viral infection. Cholesterol modifying drugs have a potential to change the life cycle of the virus, resulting in a range of pleiotropic effect on infectivity, immunity and inflammation, such as statins, fibrates, ezetimibe, proprotein convertase subtilisin/kexin type 9 inhibitors (iPCSK9), omega-3 fatty acids, bile acids sequestrants and nicotinic acid. As dyslipidemia is one of the main risk factors for the severe form of COVID-19, causing endothelial dysfunction previously installed in dyslipidemic patients, the use of lipid-lowering drugs can reduce the risk factors for the unfavorable outcome in these patients.

Author Biographies

Jéssica Abdo Gonçalves Tosatti, Universidade Federal de Minas Gerais

Faculdade de Farmácia da UFMG

Cinthia Elim Jannes, Universidade de São Paulo

Laboratório de Genética do Instituto do Coração (INCOR)

Iêda de Fátima Oliveira Silva, Universidade Federal Minas Gerais

Faculdade de Farmácia da UFMG

Karina Braga Gomes, Universidade Federal Minas Gerais

Faculdade de Farmácia da UFMG

Faculdade de Medicina da UFMG

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13/07/2022

How to Cite

SILVINO, J. P. de P. .; TOSATTI, J. A. G. .; JANNES, C. E. .; SILVA, I. de F. O. .; GOMES, K. B. . COVID-19, dyslipidemia and familial hypercholesterolemia: an up-date . Research, Society and Development, [S. l.], v. 11, n. 9, p. e38411931975, 2022. DOI: 10.33448/rsd-v11i9.31975. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/31975. Acesso em: 13 aug. 2022.

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Health Sciences