Nutritional profile and its relationship with severity markers in adults with sickle cell anemia

Authors

DOI:

https://doi.org/10.33448/rsd-v11i9.32144

Keywords:

Sickle cell disease; Dietary intake; Anthropometry; Hemolysis; Adults.

Abstract

Objective: To assess the nutritional profile and its relationship with the severity markers in adults with sickle cell anemia (SCA). Methodology: This is a cross-sectional, analytical study with 55 adults with SCA and 60 members of the control group. Sociodemographic, nutritional and laboratory data, as well as physical activity level were collected between March 2019 and June 2020. Mann-Whitney tests were used to compare groups and the Spearman correlation coefficient to test the relationship between variables. Results: The SCA group presented lower weight, height and body mass index. In addition, there was a positive correlation of hemoglobin and hematocrit with food intake and a negative correlation with platelets in this group. Conclusion: In light of the studied link between food intake and blood count, the importance of adequate nutritional support as part of the therapeutic management of individuals with SCA becomes evident, which impacts their prognosis.

References

Abdul-Hussein, H. K., Al-Mammori, H. S., & Hassan, M. K. (2021). Evaluation of the expression of red blood cell CD36, interleukin-6 and interleukin-8 in sickle cell anemia pediatric patients. Cytokine, 143, 155534. https://doi.org/10.1016/j.cyto.2021.155534

Animasahun, B. A., Temiye, E. O., Ogunkunle, O. O., Izuora, A. N., & Njokanma, O. F. (2011). The influence of socioeconomic status on the hemoglobin level and anthropometry of sickle cell anemia patients in steady state at the Lagos University Teaching Hospital. Nigerian journal of clinical practice, 14(4), 422–427. https://doi.org/10.4103/1119-3077.9174

Connes, P., Machado, R., Hue, O., & Reid, H. (2011). Exercise limitation, exercise testing and exercise recommendations in sickle cell anemia. Clinical hemorheology and microcirculation, 49(1-4), 151–163. https://doi.org/10.3233/CH-2011-1465

Craig, C. L., Marshall, A. L., Sjöström, M., Bauman, A. E., Booth, M. L., Ainsworth, B. E., Pratt, M., Ekelund, U., Yngve, A., Sallis, J. F., & Oja, P. (2003). International physical activity questionnaire: 12-country reliability and validity. Medicine and science in sports and exercise, 35(8), 1381–1395. https://doi.org/10.1249/01.MSS.0000078924.61453.FB

de Jesus, A. C. da S., Konstantyner, T., Lôbo, I. K. V., & Braga, J. A. P. (2018). SOCIOECONOMIC AND NUTRITIONAL CHARACTERISTICS OF CHILDREN AND ADOLESCENTS WITH SICKLE CELL ANEMIA: A SYSTEMATIC REVIEW. Revista Paulista de Pediatria, 36(4), 491–499. https://doi.org/10.1590/1984-0462/;2018;36;4;00010

Gomes, I. C. P., Melo, H. N., Melo, S. I. A., Menezes, N. V. de, Dantas, T. V. P., & Cipolotti, R. (2017). Growth and puberty in a prospective cohort of

patients with sickle-cell anaemia: an assessment over ten years abstract. Journal of Human Growth and Development, 27(1), 91. https://doi.org/10.7322/jhgd.127681

Hankins, J. S., Estepp, J. H., Hodges, J. R., Villavicencio, M. A., Robison, L. L., Weiss, M. J., Kang, G., Schreiber, J. E., Porter, J. S., Kaste, S. C., Saving, K. L., Bryant, P. C., Deyo, J. E., Nottage, K. A., King, A. A., Brandow, A. M., Lebensburger, J. D., Adesina, O., Chou, S. T., & Zemel, B. S. (2018). Sickle Cell Clinical Research and Intervention Program (SCCRIP): A lifespan cohort study for sickle cell disease progression from the pediatric stage into adulthood. Pediatric Blood & Cancer, 65(9), e27228. https://doi.org/10.1002/pbc.27228

Inusa, B., Hsu, L. L., Kohli, N., Patel, A., Ominu-Evbota, K., Anie, K. A., & Atoyebi, W. (2019). Sickle Cell Disease-Genetics, Pathophysiology, Clinical Presentation and Treatment. International journal of neonatal screening, 5(2), 20. https://doi.org/10.3390/ijns5020020

Kamal, S., Naghib, M. M., Al Zahrani, J., Hassan, H., Moawad, K., & Arrahman, O. (2021). Influence of Nutrition on Disease Severity and Health-related Quality of Life in Adults with Sickle Cell Disease: A Prospective Study. Mediterranean journal of hematology and infectious diseases, 13(1), e2021007. https://doi.org/10.4084/MJHID.2021.007

Kato, G. J., Piel, F. B., Reid, C. D., Gaston, M. H., Ohene-Frempong, K., Krishnamurti, L., Smith, W. R., Panepinto, J. A., Weatherall, D. J., Costa, F. F., & Vichinsky, E. P. (2018). Sickle cell disease. Nature reviews. Disease primers, 4, 18010. https://doi.org/10.1038/nrdp.2018.10

Kawchak, D. A., Schall, J. I., Zemel, B. S., Ohene-Frempong, K., & Stallings, V. A. (2007). Adequacy of dietary intake declines with age in children with sickle cell disease. Journal of the American Dietetic Association, 107(5), 843–848. https://doi.org/10.1016/j.jada.2007.02.015

Martin, C., Pialoux, V., Faes, C., Charrin, E., Skinner, S., & Connes, P. (2018). Does physical activity increase or decrease the risk of sickle cell disease complications?. British journal of sports medicine, 52(4), 214–218. https://doi.org/10.1136/bjsports-2015-095317

Makani, J., Cox, S. E., Soka, D., Komba, A. N., Oruo, J., Mwamtemi, H., Magesa, P., Rwezaula, S., Meda, E., Mgaya, J., Lowe, B., Muturi, D., Roberts, D. J., Williams, T. N., Pallangyo, K., Kitundu, J., Fegan, G., Kirkham, F. J., Marsh, K., & Newton, C. R. (2011). Mortality in sickle cell anemia in Africa: a prospective cohort study in Tanzania. PloS one, 6(2), e14699. https://doi.org/10.1371/journal.pone.0014699

Mikobi, T. M., Lukusa Tshilobo, P., Aloni, M. N., Mvumbi Lelo, G., Akilimali, P. Z., Muyembe-Tamfum, J. J., Race, V., Matthijs, G., & Mbuyi Mwamba, J. M. (2015). Correlation between the Lactate Dehydrogenase Levels with Laboratory Variables in the Clinical Severity of Sickle Cell Anemia in Congolese Patients. PloS one, 10(5), e0123568. https://doi.org/10.1371/journal.pone.0123568

Moreira G., Neto L, Fernandes P, Ficarelli V. (2002) Aspectos fisiológicos da atividade física em portadores da anemia falciforme (monografia) UNIFESP/EPM. São Paulo.

Nartey, E. B., Spector, J., Adu-Afarwuah, S., Jones, C. L., Jackson, A., Ohemeng, A., Shah, R., Koryo-Dabrah, A., Kuma, A. B., Hyacinth, H. I., & Steiner-

Asiedu, M. (2021). Nutritional perspectives on sickle cell disease in Africa: a systematic review. BMC nutrition, 7(1), 9. https://doi.org/10.1186/s40795-021-00410-w

Odetunde, O. I., Chinawa, J. M., Achigbu, K. I., & Achigbu, E. O. (2016). Body mass index and other anthropometric variables in children with sickle cell anaemia. Pakistan journal of medical sciences, 32(2), 341–346. https://doi.org/10.12669/pjms.322.9046

Oredugba, F. A., & Savage, K. O. (2002). Anthropometric finding in Nigerian children with sickle cell disease. Pediatric dentistry, 24(4), 321–325.

Oyedeji, C., Strouse, J. J., Crawford, R. D., Garrett, M. E., Ashley-Koch, A. E., & Telen, M. J. (2019). A multi-institutional comparison of younger and older adults with sickle cell disease. American journal of hematology, 94(4), E115–E117. https://doi.org/10.1002/ajh.25405

Piccin, A., Murphy, C., Eakins, E., Rondinelli, M. B., Daves, M., Vecchiato, C., Wolf, D., Mc Mahon, C., & Smith, O. P. (2019). Insight into the complex pathophysiology of sickle cell anaemia and possible treatment. European journal of haematology, 102(4), 319–330. https://doi.org/10.1111/ejh.13212

Physical status: the use and interpretation of anthropometry. Report of a WHO Expert Committee. (1995). World Health Organization technical report series, 854, 1–452.

Piel, F. B., Steinberg, M. H., & Rees, D. C. (2017). Sickle Cell Disease. The New England journal of medicine, 376(16), 1561–1573. https://doi.org/10.1056/NEJMra1510865

Protocolo Clínico e Diretrizes Terapêuticas Doença Falciforme. (2016). http://conitec.gov.br/images/Consultas/Relatorios/2016/Relatorio_PCDT_DoencaFalciforme_CP_2016_v2.pdf

Reid M. (2013). Nutrition and sickle cell disease. Comptes rendus biologies, 336(3), 159–163. https://doi.org/10.1016/j.crvi.2012.09.007

Salinas Cisneros, G., & Thein, S. L. (2020). Recent Advances in the Treatment of Sickle Cell Disease. Frontiers in physiology, 11, 435. https://doi.org/10.3389/fphys.2020.00435

Segava, N., Cavalcanti, A., Godoi De Paula, F., & Mendes, L. (1428). Caracterização do uso de atividades físicas em crianças e adolescentes com anemia falciforme Characterization of the use of physical activities of children and adolescents with sickle cell anemia. https://doi.org/10.11606/issn.2238-6149.v24i3p242-9

Singhal, A., Davies, P., Sahota, A., Thomas, P. W., & Serjeant, G. R. (1993). Resting metabolic rate in homozygous sickle cell disease. The American journal of clinical nutrition, 57(1), 32–34. https://doi.org/10.1093/ajcn/57.1.32

Singhal, A., Parker, S., Linsell, L., & Serjeant, G. (2002). Energy intake and resting metabolic rate in preschool Jamaican children with homozygous sickle cell disease. The American journal of clinical nutrition, 75(6), 1093–1097. https://doi.org/10.1093/ajcn/75.6.1093

Soares, A., Dorlivete, P., Shitsuka, M., Parreira, F., & Shitsuka, R. (n.d.). METODOLOGIA DA PESQUISA CIENTÍFICA. https://www.ufsm.br/app/uploads/sites/358/2019/02/Metodologia-da-Pesquisa-Cientifica_final.pdf

Smiley, D., Dagogo-Jack, S., & Umpierrez, G. (2008). Therapy insight: metabolic and endocrine disorders in sickle cell disease. Nature clinical practice. Endocrinology & metabolism, 4(2), 102–109. https://doi.org/10.1038/ncpendmet0702

Sundd, P., Gladwin, M. T., & Novelli, E. M. (2019). Pathophysiology of Sickle Cell Disease. Annual review of pathology, 14, 263–292. https://doi.org/10.1146/annurev-pathmechdis-012418-012838

Wongtong, N., Jones, S., Deng, Y., Cai, J., & Ataga, K. I. (2015). Monocytosis is associated with hemolysis in sickle cell disease. Hematology (Amsterdam, Netherlands), 20(10), 593–597. https://doi.org/10.1179/1607845415Y.0000000011

Published

18/07/2022

How to Cite

GOMES, I. C. P.; CARVALHO, M. A.; CRUZ, M. C. P.; TELES , J. P. C. M.; OLIVEIRA, P. G. P. R. de .; ALBUQUERQUE, L. C. de; COSTA, G. M. A.; CARVALHO, A. F.; CIPOLOTTI, R. Nutritional profile and its relationship with severity markers in adults with sickle cell anemia . Research, Society and Development, [S. l.], v. 11, n. 9, p. e54611932144, 2022. DOI: 10.33448/rsd-v11i9.32144. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/32144. Acesso em: 12 nov. 2024.

Issue

Section

Health Sciences