Antidiabetic properties of beer enriched with Baccharis dracunculifolia
DOI:
https://doi.org/10.33448/rsd-v11i11.33720Keywords:
Natural products; Health promotion; Diabetes; Dyslipidemia.Abstract
Objective: The objective of the present study was to verify the metabolic responses of a beer with Baccharis dracunculifolia added in diabetic patients. Methodology: Participants in the study were 06 volunteer individuals diagnosed with type 2 diabetes mellitus. Biochemical analysis and physical evaluation took place before and after 30 days of treatment with beer with B. dracunculifolia. Results: After receiving the beer treatment with B. dracunculifolia, the patients showed a decrease in creatinine levels (23%). Alkaline phosphatase also had a reduction (23%) in its production. In addition, a reduction in the lipid profile for LDL (15%) was observed. Still, the levels of TGO and TGP had a significant reduction of 42% and 25%, respectively. Blood glucose levels after treatment reduced margins by 22%. Conclusion: In conclusion, beer enriched with B. dracunculifolia offers promising therapeutic value in preventing diabetes and dyslipidemic profile.
References
Achi, N. K., Ohaeri, O. C., & Ijeh, I. I. (2017). Modulation of the lipid profile and insulin levels of streptozotocin induced diabetic rats by ethanol extract of Cnidoscolus aconitifolius leaves and some fractions: Effect on the oral glucose tolerance of normoglycemic rats. Biomed Pharmacother. 86: 562–569.
Ahangarpour, A., Heidari, H., & Oroojan, A.A. (2017). Antidiabetic, hypolipidemic and hepatoprotective effects of Arctium lappa root’s hydro-alcoholic extract on nicotinamide-streptozotocin induced type 2 model of diabetes in male mice. Avicenna J Phytomed. 7(2): 169–179.
American Diabetes Association. 1. Promoting Health and Reducing Disparities in Populations. Diabetes Care, v. 40, n. Supplement 1, p. S6-S10, 2017.
Araújo, R. F. J., Costa, C. H. C. Martins, L. A. J., & Coelho, C. S. (2016). Determinação do extrato real e primitivo de cervejas. In: Congresso Latino Americano E Brasileiro De Ciência E Mercado Cervejeiro, julh, 2016, Blumenau – SC. Anais. < http://www.cervecon.com.br/Uploads/anais.pdf>
Barbosa, T. M. Desenvolvimento de Cerveja Artesanal com Polpa de Maracujá Amarelo (Passiflora Edulis F. FlavicarpaDeg) e Avaliação da Imobilização de Células de SaccharomycesCerevisiae no Processo de Fermentação Alcoólica. Monografia. Curso de Farmácia. Universidade de Brasília, 2016.
Bloom, D. E. (2011). The global economic burden of non-communicable diseases: report by the World Economic Forum and the Harvard School of Public Health. Geneva: World EconomicForum; 2011. 47
Brito, A. N. M. De., Macedo, J. L., Carvalho, S. De L., Oliveira, J. V. F. De., Brito, F. N. M., Pinheiro, A. O., Costa, P. V. De C., & Silva, D. J. S. Effectiveness of diet therapy for patients with diabetes mellitus. Research, Society and Development, [S. l.], 9(1), e114911728, 2020. 10.33448/rsd-v9i1.1728.
Castro, I. B., Câmara, G. B., De Pontes, J. F., Viana, D. L., De Souza, R. P., Silva Nobrega, E. D., Lira, R. B. De B., & Barbosa, L. S. de L. T. Nutritional strategies in the treatment of diabetes mellitus: bibliographic review. Research, Society and Development, [S. l.], 9(2), e133922193, 2020. 10.33448/rsd-v9i2.2193.
Effiom, E.O., Abam, K., & Ekpo, G. (2019). Anti-diabetic Effect of Two Medicinal Plants: Cataranthus roseus and Nauclea latifolium on Some Biochemical Indices of Streptozotocin Induced Diabetic Albino Wistar Rats. J Pharmaceutical Res International. 29(3): 1–14
El-Sayed, E. S. M., Abo-Salem, O. M., & Aly, H. A. (2019) Potential antidiabetic and hypolipidemic effects of propolis extract in streptozotocin-induced diabetic rats. Pak. J Pharm. Sci. 2009; 22(2)
Garcia, L. P., & Freitas, L. R. S. (2015). Consumo abusivo de álcool no Brasil: resultados da Pesquisa Nacional de Saúde 2013. Epidemiologia e Serviços de Saúde, 24(2), 227-237.
Guimarães, B. M., Ramos, K. A., Souza, M. C. De, Franco, M. L., Alves, C. C. De S., Carli, A. De P., & Coqueiro, J. M. Therapeutic practices with medicinal plants for the treatment of Diabetes Mellitus. Research, Society and Development, [S. l.], 10(10), e474101018874, 2021. 10.33448/rsd-v10i10.18874.
Instituto Nacional de Câncer. Inquérito domiciliar sobre comportamentos de risco e morbidade referida de doenças e agravos não transmissíveis: Brasil, 15 capitais e Distrito Federal, 2002-2003. 2004.
Kim, M. J., & Kim, H. K. (2012). Insulinotrophic and hypolipidemic effects of Ecklonia cava in streptozotocin–induced diabetic mice. Asian Pac J Trop Med. 5(5): 374–379.
Leahy, J. L. (2005). Pathogenesis of Type 2 diabetes mellitus. Arch Med Res 36:197–209.
Leonardi, C. (2016). Interações medicamentosas potenciais em idosas institucionalizadas. DisciplinarumScientia| Saúde. 13(2):181-189.
Lima, A. C. B. M. (2015). Consumo de flavonoides totais e cítricos de indivíduos com e sem doenças auto-referidas e hábitos de vida para prevenção de doenças crônicas não transmissíveis. 2015. 38 f. Dissertação (mestrado) - Universidade Estadual Paulista Julio de Mesquita Filho, Faculdade de Ciências Farmacêuticas, 2015.
Marcucci, M. C., Ferreres, F., & García-Viguera, C. (2001). Phenolic compounds from Brazilian propolis with pharmacological activities. J Ethnopharmacol 74:105–12.
Momin, Y. H., & Yeligar, V. C. (2019). The antidiabetic and antioxidant activity of Coccinea grandis voigt stem extract in streptozotocin induced diabetic rats. J Drug Deliv Ther. 9: 390–395.
Noor, A., Gunasekaran, S., & Vijayalakshmi, M.A. (2007). Improvement of insulin secretion and pancreatic β-cell function in streptozotocin-induced diabetic rats treated with Aloe vera extract. Pharm Res. 9(Suppl 1): S99–S104.
Prnova, M. S., Kovacikova, L., & Svik, K. (2020). Triglyceride-lowering effect of the aldose reductase inhibitor cemtirestat—another factor that may contribute to attenuation of symptoms of peripheral neuropathy in STZ-diabetic rats. Naunyn Schmiedeberg's Arch. Pharmacol. 393: 651–661.
Reis, J. T. (2015). Setor de Bebidas no Brasil: Beverage Sector in Brazil: Preliminary Scopeand Configuration. Rosa Dos Ventos. 7(2):1-5.
Rodrigues, K. L. (2016). Propriedades anti-inflamatória e antiulcerogênica de uma cerveja fermentada unicamente por grãos de quefir. 2016. 96 f. Tese (Doutorado em Ciências Fisiológicas) - Universidade Federal de Alfenas, Alfenas, MG, 2016.
Soares, M. V. (2015). Utilização de Coproduto Vinicola na Formulação de Cervejas Artesanais. Trabalho de Conclusão de Curso. Curso de Engenharia de Alimentos da Universidade Federal do Pampa, Bagé, 2015.
Ueda, M., Hayashibara, K., & Ashida, H. (2013). Propolis extract promotes translocation of glucose transporter 4 and glucose uptake through both PI3K- and AMPK-dependent pathways in skeletal muscle. Biofactors 39:457–66.
Wei, A., Mura, K., & Shibamoto, T. (2001). Antioxidative activity of volatile chemicals extracted from beer. J Agricultural Food Chemistry. 49:4097–4101.
Weiss, E. P., Brandauer, J., & Kulaputana, O. (2007). FABP2 Ala54Thr genotype is associated with glucoregulatory function and lipid oxidation after a high-fat meal in sedentary nondiabetic men and women. Am J Clin Nutr 85:102–8.
World Health Organization. Health topics: Chronic diseases. Geneva: World Health Organization, 2013. http://www. who.int/topics/chronic_diseases/en/
Wright, C. A. (2008). Beer Consumer´s perceptions of the Health Aspects of Alcoholic Beverages. Journal of Food Science. 2008b, 73(1) : H12-H17.
Yoshida, V. C., & Andrade, M. G. G. O cuidado à saúde na perspectiva de trabalhadores homens portadores de doenças crônicas. (2016). Interface, 20(58),597-610. doi: 10.1590/1807-57622015.0611
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Marcieli Cristina da Silva; Luiz Augusto da Silva; Carlos Ricardo Maneck Malfatti; Kelly Cristina Nogueira Soares
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
