Clinical applications of curcumin (Curcuma longa) in oral disorders
DOI:
https://doi.org/10.33448/rsd-v9i7.3789Keywords:
Curcumin; Phytotherapy; Mouth Diseases.Abstract
Curcumin is an yellow pigment that is present in the rhizome of turmeric (Curcuma longa), a plant related to the ginger family (Zingiberaceae), originally from India. It is mainly used in cooking and aesthetics, but is also widespread in folk medicine, in the form of teas, gels and ointments. The aim of this study was to ascertain in the literature the clinical potential of curcumin in disorders in the bucomaxillofacial complex. For this, an integrative literature research published in the range from 2000 to 2020 was carried out in the online databases PubMed (National Libary of Medicine) and ScienceDirect. Using Descriptors and Synonyms MeSH, following 3 semantic fields: "Curcumin" in association with "Oral and Maxillofacial Pathology" and "Pharmacological Therapy". From the 986 articles found, 20 were included in this article after the application of inclusion criteria, where significantly positive results were observed in treatments of pathologies such as leukoplakia, cystic adenoid carcinoma, lichen planus, submucosal fibrosis, oral mucositis and candidiasis. In addition, post-surgical complications such as pain, inflammatory edema and alveolar osteitis also had attenuated signs and symptoms due to the use of curcuminoids. In this sense, curcumin applies to dentistry as an anti-inflammatory, antifungal, antineoplastic and healing.
References
Anitha, V, Rajesh, P, Shanmugam, M, Meena Priya, B, Prabhu, S & Shivakumar, V. (2015). Comparative evaluation of natural curcumin and synthetic chlorhexidine in the management of chronic periodontitis as a local drug delivery: A clinical and microbiological study. Indian Journal of Dental Research, 26(1), 53–56.
Araújo, C. A. C., & Leon, L. L. (2001). Biological activities of Curcuma longa L. Memorias Do Instituto Oswaldo Cruz, 96(5), 723–728.
Carrozzo, M, Porter, S, Mercadante, V & Fedele, S. (2019). Oral lichen planus: A disease or a spectrum of tissue reactions? Types, causes, diagnostic algorhythms, prognosis, management strategies. Periodontology 2000, 80(1), 105–125.
Cecilia, M, Bruning, R, Bittencourt, G & Mosegui, G. (2012). A utilização da fitoterapia e de plantas medicinais em unidades básicas de saúde nos municípios de Cascavel e Foz do Iguaçu - Paraná: a visão dos profissionais de saúde. Ciência & Saúde Coletiva, 17(10), 2675–2686.
Chainani-Wu, N, Silverman, S, Reingold, A, Bostrom, A, Mc Culloch, C, Lozada-Nur, F & Weintraub, J. (2007). A randomized, placebo-controlled, double-blind clinical trial of curcuminoids in oral lichen planus. Phytomedicine, 14(7–8), 437–446.
Chen, AL, Hsu, CH, Lin, JK, Hsu, MM, Ho, YF, She, TS, Ko, JY, Lin, JT, Lin, BR, Wu, MS, Yu, HS, Jee, SH, Chen, GS, Chen, TM, Chen, CA, Lai, MK, Pu, YS, Pan, MH, Wang, YJ, & Hsieh, CY. (2001). Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Research, 21(4), 2895–2900.
Cruz-Correa, M, Shoskes, DA, Sanchez, P, Zhao, R, Hylind, LM, Wexner, SD, & Giardiello, FM. (2006). Combination Treatment With Curcumin and Quercetin of Adenomas in Familial Adenomatous Polyposis. Clinical Gastroenterology and Hepatology, 4(8), 1035–1038.
Delavarian, Z, Pakfetrat, A, Ghazi, A, Jaafari, MR, Homaei Shandiz, F, Dalirsani, Z, Mohammadpour, AH & Rahimi, HR. (2019). Oral administration of nanomicelle curcumin in the prevention of radiotherapy-induced mucositis in head and neck cancers. Special Care in Dentistry, 39(2), 166–172.
Demiray, M, Sahinbas, H, Atahan, S, Demiray, H, Selcuk, D, Yildirim, I & Atayoglu, AT. (2016). Successful treatment of c-kit-positive metastatic Adenoid Cystic Carcinoma (ACC) with a combination of curcumin plus imatinib: A case report. Complementary Therapies in Medicine, 27, 108–113.
Donato, HAR, Pratavieira, S, Grecco, C, Brugnera-Júnior, A, Bagnato, VS & Kurachi, C. (2017). Clinical Comparison of Two Photosensitizers for Oral Cavity Decontamination. Photomedicine and Laser Surgery, 35(2), 105–110.
Hewlings, S & Kalman, D. (2017). Curcumin: A Review of Its’ Effects on Human Health. Foods, 6(10), 92.
Ivanaga, CA, Miessi, DMJ, Nuernberg, MAA, Claudio, MM, Garcia, VG & Theodoro, LH. (2019). Antimicrobial photodynamic therapy (aPDT) with curcumin and LED, as an enhancement to scaling and root planing in the treatment of residual pockets in diabetic patients: A randomized and controlled split-mouth clinical trial. Photodiagnosis and Photodynamic Therapy, 27(July), 388–395.
Jamshidi-Kia, F, Lorigooini, Z & Amini-Khoei, H. (2018). Medicinal plants: Past history and future perspective. Journal of HerbMed Pharmacology, 7(1), 1–7.
Joshi, J, Ghaisas, S, Vaidya, A, Kamat, DV, Bhagwat, AN & Bhide, S. (2003). Early human safety study of turmeric oil (curcuma longa oil) administered orally in healthy volunteers. Japi, 51(1), 1055–1060.
Kassebaum, NJ, Bernabé, E, Dahiya, M, Bhandari, B, Murray, CJL & Marcenes, W. (2014). Global burden of severe periodontitis in 1990-2010: A systematic review and meta-regression. Journal of Dental Research, 93(11), 1045–1053.
Kaur, H, Grover, V, Malhotra, R & Mili, G. (2019). Evaluation of curcumin gel as adjunct to scaling & root planing in management of periodontitis– Randomized clinical & biochemical investigation. Infectious Disorders - Drug Targets, 19(2), 171–178.
Kocaadam, B & Şanlier, N. (2017). Curcumin, an active component of turmeric (Curcuma longa), and its effects on health. Critical Reviews in Food Science and Nutrition, 57(13), 2889–2895.
Kotha, RR & Luthria, DL. (2019). Curcumin: Biological, pharmaceutical, nutraceutical, and analytical aspects. Molecules, 24(16), 1–27.
Kuriakose, MA., Ramdas, K, Dey, B, Iyer, S, Rajan, G, Elango, KK, Suresh, A, Ravindran, D, Kumar, RR., Prathiba, R, Ramachandran, S, Kumar, NA, Thomas, G, Somanathan, T, Ravindran, HK, Ranganathan, K, Katakam, SB, Parashuram, S, Jayaprakash, V & Pillai, MR. (2016). A randomized double-blind placebo-controlled phase iib trial of curcumin in oral leukoplakia. Cancer Prevention Research, 9(8), 683–691.
Lalla, RV, Brennan, MT, Gordon, SM, Sonis, ST, Rosenthal, DI & Keefe, DM. (2019). Oral Mucositis Due to High-Dose Chemotherapy and/or Head and Neck Radiation Therapy. Journal of the National Cancer Institute - Monographs, 2019(53), 17–24.
Leite, DPV, Paolillo, FR, Parmesano, TN, Fontana, CR & Bagnato, VS. (2014). Effects of photodynamic therapy with blue light and curcumin as mouth rinse for oral disinfection: A randomized controlled trial. Photomedicine and Laser Surgery, 32(11), 627–632.
Lone, PA, Ahmed, SW, Prasad, V & Ahmed, B. (2018). Role of turmeric in management of alveolar osteitis (dry socket): A randomised clinical study. Journal of Oral Biology and Craniofacial Research, 8(1), 44–47.
Marques, ECP, Lopes, FP, Nascimento, IC, Morelli, J, Pereira, MV, Machado Meiken, VM, & Pinheiro, SL. (2020). Photobiomodulation and photodynamic therapy for the treatment of oral mucositis in patients with cancer. Photodiagnosis and Photodynamic Therapy, 29(1), 1–15.
Maulina, T, Diana, H, Cahyanto, A & Amaliya, A. (2018). The efficacy of curcumin in managing acute inflammation pain on the post-surgical removal of impacted third molars patients: A randomised controlled trial. Journal of Oral Rehabilitation, 45(9), 677–683.
Muglikar, S, Patil, KC, Shivswami, S & Hegde, R. (2013). Efficacy of curcumin in the treatment of chronic gingivitis: A pilot study. Oral Health and Preventive Dentistry, 11(1), 81–86.
Mustafa, MW, Ungphaiboon, S, Phadoongsombut, N, Pangsomboon, K, Chelae, S & Mahattanadul, S. (2019). Effectiveness of an alcohol-free chitosan-curcuminoid mouthwash compared with chlorhexidine mouthwash in denture stomatitis treatment: A randomized trial. Journal of Alternative and Complementary Medicine, 25(5), 552–558.
Needleman, I, Garcia, R, Gkranias, N, Kirkwood, KL, Kocher, T, Iorio, AD, Moreno, F & Petrie, A. (2018). Mean annual attachment, bone level, and tooth loss: A systematic review. Journal of Clinical Periodontology, 45(7), 112–129.
Nosratzehi, T, Arbabi-Kalati, F, Hamishehkar, H & Bagheri, S. (2018). Comparison of the Effects of Curcumin Mucoadhesive Paste and Local Corticosteroid on the Treatment of Erosive Oral Lichen Planus Lesions. Journal of the National Medical Association, 110(1), 92–97.
Panahi, Y, Hosseini, MS, Khalili, N, Naimi, E, Majeed, M & Sahebkar, A. (2015). Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysis. Clinical Nutrition, 34(6), 1101–1108.
Panhóca, VH, Florez, FLE, Corrêa, TQ, Paolillo, FR, Souza, CWO & Bagnato, VS. (2016). Oral decontamination of orthodontic patients using photodynamic therapy mediated by blue-light irradiation and curcumin associated with sodium dodecyl sulfate. Photomedicine and Laser Surgery, 34(9), 411–417.
Pereira, A.S. et al. (2018). Metodologia da pesquisa científica. [e-book]. Santa Maria. Ed. UAB/NTE/UFSM. Acesso em: 5 maio 2020. Disponível em: https://repositorio.ufsm.br/bitstream/handle/1/15824/Lic_Computacao_Metodologia-Pesquisa-Cientifica.pdf?sequence=1.
Pinheiro, SL, Bonadiman, AC, Anjos Borges Lemos, AL, Annicchino, BM, Segatti, B, Pucca, DS, Dutra, PT, Carvalho e Silva, RM & Leal, F. (2019). Photobiomodulation Therapy in Cancer Patients with Mucositis: A Clinical Evaluation. Photobiomodulation, Photomedicine, and Laser Surgery, 37(3), 142–150.
Piyush, P, Mahajan, A, Singh, K, Ghosh, S & Gupta, S. (2019). Comparison of therapeutic response of lycopene and curcumin in oral submucous fibrosis: A randomized controlled trial. Oral Diseases, 25(1), 73–79.
Pulikkotil, SJ & Nath, S. (2015). Effects of curcumin on crevicular levels of IL-1β and CCL28 in experimental gingivitis. Australian Dental Journal, 60(3), 317–327.
Rao, S, Dinkar, C, Vaishnav, LK, Rao, P, Rai, MP, Fayad, R & Baliga, MS. (2014). The Indian spice turmeric delays and mitigates radiation-induced oral mucositis in patients undergoing treatment for head and neck cancer: An investigational study. Integrative Cancer Therapies, 13(3), 201–210.
Santezi, C, Reina, BD & Dovigo, LN. (2018). Curcumin-mediated Photodynamic Therapy for the treatment of oral infections—A review. In Photodiagnosis and Photodynamic Therapy.
Santos Filho, EX, Arantes, DAC, Oton Leite, AF, Batista, AC, Mendonça, EF, Marreto, RN, Naves, LN, Lima, EM & Valadares, MC. (2018). Randomized clinical trial of a mucoadhesive formulation containing curcuminoids (Zingiberaceae) and Bidens pilosa Linn (Asteraceae) extract (FITOPROT) for prevention and treatment of oral mucositis - phase I study. Chemico-Biological Interactions, 291, 228–236.
Saran, G, Umapathy, D, Misra, N, Channaiah, S, Singh, P, Srivastava, S & Shivakumar, S. (2018). A comparative study to evaluate the efficacy of lycopene and curcumin in oral submucous fibrosis patients: A randomized clinical trial. Indian Journal of Dental Research, 29(3), 303–312.
Singh, A, Sridhar, R, Shrihatti, R & Mandloy, A. (2018). Evaluation of Turmeric Chip Compared with Chlorhexidine Chip as a Local Drug Delivery Agent in the Treatment of Chronic Periodontitis: A Split Mouth Randomized Controlled Clinical Trial. Journal of Alternative and Complementary Medicine, 24(1), 76–84.
Sodhi, S, Sodhi, JS, Khambete, N, Kumar, R, Marthala, M, & Sodhi, NK. (2014). Expression of tumor necrosis factor α and its correlation with severity of oral submucous fibrosis: A case-control study. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 117(6), 704–708.
Sueth-Santiago, V, Mendes-Silva, GP, Decoté-Ricardo, D & De Lima, MEF. (2015). Curcumina, o pó dourado do açafrão-da-terra: Introspecções sobre química e atividades biológicas. Quimica Nova, 38(4), 538–552.
Tsuda, T. (2018). Curcumin as a functional food-derived factor: Degradation products, metabolites, bioactivity, and future perspectives. Food and Function, 9(2), 705–714.
Waghmare, PF, Chaudhari, AU, Karhadkar, VM & Jamkhande, AS. (2011). Comparative evaluation of turmeric and chlorhexidine gluconate mouthwash in prevention of plaque formation and gingivitis: A clinical and microbiological study. Journal of Contemporary Dental Practice, 12(4), 221–224.
Xu, XY, Meng, X, Li, S, Gan, RY, Li, Y & Li, HB. (2018). Bioactivity, health benefits, and related molecular mechanisms of curcumin: Current progress, challenges, and perspectives. Nutrients, 10(10).
Downloads
Published
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.