Occurrence and significance of coumarin in cachaça stored in amburana
DOI:
https://doi.org/10.33448/rsd-v12i1.39667Keywords:
Coumarin; Cachaça; Amburana casks; Amburana cearensis.Abstract
Coumarin (1,2-benzopyrone) is a phenolic compound of vegetal origin. Beside its wide use in human medicine, it is also used as an odorant in food, beverages, cosmetics and perfumery, and as a bioactive component in nutraceutical foods. However, due to the risk of hepatotoxicity and other adverse effects in more sensitive people, international health agencies recommend a limit of 0.1 mg/kg/day for daily intake. Following a worldwide trend, Brazilian legislation recently established a limit of 10 mg/kg for coumarin in alcoholic beverages. With the aim of investigating the level of compliance of cachaça stored in amburana to the established limit, the coumarin content in twelve commercial cachaças, whose labels inform storage in amburana, was analyzed. The average result was above the established value, pointing to the need for monitoring and control. Given the diversity of Brazilian woods, there was a warning sign for cachaça to be stored exclusively in barrels of well-characterized species within the extractive fraction.
References
Abraham, K., Wöhrlin, F., Lindtner, O., Heinemeyer, G. & Lampen, A. (2010). Toxicology and risk assessment of coumarin: focus on human data. Mol. Nutr. Food Res., 54 (2), 228–239. 10.1002/MNFR.200900281
Brasil (2008). Ministério da Saúde. Agência Nacional de Vigilância Sanitária. Instrução Normativa n° 5 de 11 de dezembro de 2008. Determina a publicação da "lista de medicamentos fitoterápicos de registro simplificado". Diário Oficial da União, Brasília.
Brasil (2014). Ministério da Saúde. Agência Nacional de Vigilância Sanitária. Instrução Normativa n° 2 de 13 de maio de 2014. Publica a "Lista de medicamentos fitoterápicos de registro simplificado" e a "Lista de produtos tradicionais fitoterápicos de registro simplificado". Diário Oficial da União, Brasília.
Brasil (2022). Ministério da Saúde. Agência Nacional de Vigilância Sanitária. RDC n° 225 de 1º de julho de 2022. Dispõe sobre os aditivos alimentares aromatizantes. Diário Oficial da União, Brasília.
Bairagi, S., Salaskar, P., Loke, S., Surve, N., Tandel, D. & Dusara, M. (2012). Medicinal significance of coumarins: a review. Int. J. Pharm. Research, 4 (2): 16-19.
Das, A. B., Goud, V. V. & Das, C. (2019). Phenolic compounds as functional ingredients. In: Value-added ingredients and enrichments of beverages. p. 285-323. https://doi.org/10.1016/B978-0-12-816687-1.00009-6
EC - European Commission (2008). European Parliament and Council Directive nº. 1334/2008. On flavourings and certain food ingredients with flavouring properties for use in and on food. Official J. Eur. Union: L354, 34–50.
Emami, S. & Dadashpour, S. (2015). Current developments of coumarin-based anti-cancer agents. Eur. J. Med. Chem., 102: 611-630. https://doi.org/10.1016/j.ejmech.2015.08.033
Franco, D. P., Pereira, T. M., Vitorio, F., Nadur, N. F., Lacerda, R. B. & Kümmerle, A. E. (2021). A importância das cumarinas para a química medicinal e o desenvolvimento de compostos bioativos nos últimos anos. Quim. Nova, 44 (2): 180-197. http://dx.doi.org/10.21577/0100-4042.20170654
Garg, S. S., Gupta J., Sharma S. & Sahu D. (2020). An insight into the therapeutic applications of coumarin compounds and their mechanisms of action. Eur. J. Pharm. Sci. https://doi.org/10.1016/j.ejps.2020.105424
Hassan, M. Z., Osman H., Ali, M. A. & Ahsan, M. J. (2016). Therapeutic potential of coumarins as antiviral agents, AC SC, Eur. J. Med. Chem., 123: 236 - 255. 10.1016/j.ejmech.2016.07.056
Heghes, S. C., Vostinaru, O., Mogosan, C., Miere, D., Iuga, C. A. & Filip, L. (2022). Safety profile of nutraceuticals rich in coumarins: an update. Oxid Med Cell Longev. Hindawi. 10.1155/2021/6492346
Kirsch, G., Abdelwahab, A. B. & Chaimbault, P. (2016). Natural and synthetic coumarins with effects on inflammation. Molecules, 21(10). 10.3390/molecules21101322.
Kostova, I. (2005). Synthetic and natural coumarins as cytotoxic agents. Curr. Med. Chem.-Anti-Cancer Agents, (1): 29 - 46. 10.2174/1568011053352550
Kowalczyk, P., Madej, A., Paprocki, D., Szymczak, M. & Ostaszewski R. (2020). Coumarin derivatives as new toxic compounds to selected K12, R1-R4 E. coli strains. Materials, 13 (11):2499. 10.3390/ma13112499
Lake, B. G. (1999). Coumarin metabolism, toxicity and carcinogenicity: relevance for human risk assessment. Food Chem. Toxicol.,37 (4): 423-453. https://doi.org/10.1016/S0278-6915(99)00010-1.
Lin, L.T., Hsu, W. C. & Lin, C. C. (2014). Antiviral natural products and herbal medicines. J. Tradit. Compl. Med. 4: 24–35.
Loncaric, M., Jakovljević, M., Šubarić, D., Pavlić, M., Buzjak Služek, V., Cindrić, I. & Molnar, M. (2020). Coumarins in food and methods of their determination. Foods, 9 (5): 645. 10.3390/foods9050645
Lorenzi, H. (2008). Árvores Brasileiras: Manual de identificação e cultivo de plantas arbóreas nativas do Brasil. 5 ed. Nova Odessa, SP: Instituto Plantarum, 2008.
Maia, A. B., Marinho, L. S., Nelson, D. L. (2020). Certification of amburana in the aging of cachaça. Res. Soc. Develop. (9):12. http://dx.doi.org/10.33448/rsd-v9i12.10644
Maia, A. B., Carneiro, F. B., Tonidandel, L. O., Conceição, E, C, Machado, B. D. & Marinho, L. S. (2022). Parâmetros para certificação da madeira utilizada no armazenamento de cachaça. Res. Soc. Dev. https://doi.org/10.33448/rsd-v11i15.35793
Maia, G. N. (2012). Caatinga: árvores e arbustos e suas utilidades. 2 ed. Fortaleza, Printcolor Gr. Ed.
Matos, M. J., Santana, L., Uriarte, E., Abreu, O. A. Molina, E. & Yordi, E. G. (2015). Cumarinas — uma classe importante de fitoquímicos. 10.5772/59982
Mishra, S., Pandey, A. & Manvati, S. (2020). Coumarin: an emerging antiviral agent. Heliyon. https://doi.org/10.3389/fphar.2022.803338
Rad , J. S., Martins, N. C., Jornet, P. L., Lopez, E. P. F. Harun, N., Yeskaliyeva, B., Beyatli, A., Sytar, O., Shaheen,S., Sharopov, F., Taheri, Y., Docea, A .O., Calina, D. & Cho, W. C. (2021). Natural Coumarins: exploring the pharmacological complexity and underlying molecular mechanisms. Oxid. Med. Cell Longev., 23: 6492346. 10.1155/2021/6492346.
Ruwizhi,N. & Aderibigbe, B. A. (2020). Cinnamic acid derivatives and their biological efficacy. Int. J. Mol. Sci.,21: 5712. 10.3390/ijms21165712
Santiago, W. D., Cardoso, M. G. & Nelson, D. L. (1999). Cachaça stored in casks of oak, amburana, jatoba, balsam and peroba: alcohol content, phenolic composition, colour intensity and dry extract. J. Inst. Brew., 123: 232-241. 10.1002/jib.414
SCF (1999). Scientific Committee on Food. Opinion on coumarin. p. 13-20. http://www.europa.eu.int/comm/dg24/health/sc/scf/index_em.html
SCF (2004). Opinion of the Scientific Panel on Food Additives, flavourings, processing aids and materials in contact with food (AFC) related to coumarin. EFSA J., 104: 1-36. 10.2903/J.EFSA.2004.104
SCF (2008). Coumarin in flavourings and other food ingredients with flavouring properties. Scientific opinion of the panel on food additives, flavourings, processing aids and materials in contact with food. EFSA J., 793: 1-15. https://doi.org/10.2903/j.efsa.2008.793
Seleme, E.P. (2020). Amburana. In: Flora do Brasil (2020). Jardim Botânico do Rio de Janeiro. http://floradobrasil.jbrj.gov.br/reflora/floradobrasil/FB22781
Stefanachi, A., Leonetti, F., Pisani, L., Catto, M. & Carotti A. (2018). Coumarin: a natural, privileged and versatile scaffold for bioactive compounds. Molecules, 23(2): 250. 10.3390/molecules23020250.
Thomas, V., Giles D., Basavarajaswamy G., Das, A. & Patel, A. (2017). Coumarin derivatives as anti-inflammatory and anticancer agents. Anti-Cancer Agents Med. Chem., 17(3):415–423. 10.2174/1871520616666160902094739.
Tomasset, U.L. & Mazza, G. (1980). Coumarin determination in flavoured alcoholic beverages. Riv. Viticolt. Enol., 33(5): 247-251.
Venugopala, K. N., Rashmi,V. & Odhav, B. (2013). Review on natural coumarin lead compounds for their pharmacological activity. BioMed Res. Int., Article ID 963248. 10.1155/2013/963248.
Winstel, D., Gautier, E. & Marchal, A. (2020). Role of oak coumarins in the taste of wines and spirits: identification, quantitation and sensory contribution through perceptive interactions. J. Agric. Food. Chem. 10.1021/acs.jafc.0c02619.
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Copyright (c) 2023 Amazile Biagioni Maia; Frederico Marx Brom Carneiro; Lucas Oliveira Tonidandel; Elaine Cristina da Conceição; Bárbara Dias Machado; Lorena Simão Marinho
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