Antioxidant and anti-inflammatory effects of Turmeric and its impact on muscle damage induced by physical exercise: Is there a relationship?




Exercise; Dietary Supplements; Curcuma.


Introduction: Muscle pain caused by intense physical exercise is characterized by discomfort and edema formation, especially when the body is not used to it, occurring due to microlesions of the muscle fibers, extending over a period of 24 to 72 hours. A food source of bioactive compounds with these activities is turmeric, which can be used in the prevention/recovery process of these injuries. Objective: To demonstrate the antioxidant and anti-inflammatory effects of turmeric and its impact on muscle damage induced by physical exercise. Methodology: A review research was carried out in Pubmed, Science Direct and SciELO databases. As inclusion criteria, original articles in English published between 2014 and 2020 were adopted. After initial filtering, a total of 916 articles were found, with 10 studies selected for the research. Results: 100% of the studies analyzed showed a positive effect of the use of turmeric in the attenuation of inflammatory and antioxidant markers, considering a variant dose of 90mg to 5g/day. Its ingestion also resulted in the reduction of pain perception in all studies. Longer duration protocols that performed post-exercise supplementation were more effective in reducing markers such as creatine kinase, interleukin-6, interleukin-8, interleukin-10, tumoral necrosis factor alpha, glutathione peroxidase and reduced glutathione. Conclusion: Based on the evidence found in the study, the effectiveness of using turmeric as a coadjuvant/strategy for the prevention and treatment of muscle pain caused by intense exercise can be verified.


Alistair, R., Briskei, D., Richards, A. & Rao, A. (2020). Curcumin Improves Delayed Onset Muscle Soreness and Postexercise Lactate Accumulation. Journal of Dietary Supplements, 18(5), 531-542.

Augustine, A., Chandradhara, D. & Gopi, S. (2020). The Effects of Bioavailable Curcumin (Cureit) on Delayed Onset Muscle Soreness Induced By Eccentric Continuous Exercise: A Randomized, Placebo-Controlled, Double-Blind Clinical Study. Journal of Medicinal Food, 23(5), 545-553.

Barroso, G. C. & Thiele, E. S. (2011) Lesão muscular nos atletas. Revista Brasileira de Ortopedia [online]. 6(4), 354-358.

Basham, S. A. et al. (2020). Effect of Curcumin Supplementation on Exercise-Induced Oxidative Stress, Inflammation, Muscle Damage, and Muscle Soreness. Journal of Dietary Supplements, 17(4), 401-414.

Berton, R. P. B. et al. (2012) Dano muscular: resposta inflamatória sistêmica após ações excêntricas máximas. Revista Brasileira de Educação Física e Esporte, 26(3), 367-74.

Campbell, M. S., Carlini, N. A. & Fleenor, B. S. (2020). Influence of curcumin on performance and post-exercise recovery. Critical Reviews in Food Science and Nutrition, 61(7), 1152-1162.

Foschini, D., Prestes, J. & Charro, M. A. (2007). Relação entre exercício físico, dano muscular e dor muscular de início tardio. Revista brasileira de cineantropometria e desempenho humano, 9(1), 101-106.

Francesco, D. P. et al. (2013). Comparative evaluation of the pain-relieving properties of a lecithinized formulation of curcumin (Meriva), nimesulide, and acetaminophen®. Journal of Pain Research, 6, 201–205.

Franchek, D. et al. (2014). Reduction of delayed onset muscle soreness by a novel curcumin delivery system (Meriva®): a randomised, placebo-controlled trial. Journal of the International Society of Sports Nutrition, 11, 1-10.

Galvão, T. F. & Pereira, M. G. (2014). Revisões sistemáticas da literatura: passos para sua elaboração. Epidemiologia e Serviços de Saúde. 23(1), 183-184.

Ganjali, S. et al. (2014). Investigation of the Effects of Curcumin on Serum Cytokines in Obese Individuals: A Randomized Controlled Trial. Scientific World Journal, 2014, 1-6.

Kuptniratsaikul, V. et al. (2014). Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study. Journal List, 9, 451–458.

Malm, C. et al. Leukocytes, cytokines, growth factors and hormonesin human skeletal muscle and blood after uphill ordownhill running. The Journal of Physiology, 556(3), 983-1000.

McFarlin, B.K. et al. (2016). Reduced inflammatory and muscle damage biomarkers following oral supplementation with bioavailable curcumin. BBA Clinical, 5, 72-78.

Meamarbashi, A. & Rajabi, A. (2015). Preventive effects of 10-day supplementation with saffron and indomethacin on the delayed-onset muscle soreness. Clinical Journal of Sport Medicine, 25(2), 105-112.

Moreira, F. R. & Rodrigues, K. L. (2014). Conhecimento nutricional e suplementação alimentar por praticantes de exercícios físicos. Revista Brasileira de Medicina do Esporte, 20(5), 370-373.

Nahon, R. L. et al. (2021). Anti-inflamatórios para dor muscular de início tardio: revisão sistemática e metanálise. Revista Brasileira de Medicina do Esporte, 27, 646-654.

Nakhostin, B. R., Moradlou, A. N. & Bolboli, L. (2016). Influence of Curcumin Supplementation on Exercise-Induced Oxidative Stress. Asian Journal Sports Medicine, 8(1), 1-6.

Nicol, L. M., Rowlands, D. S., Fazakerly, R. & Kellett, J. (2015). Curcumin supplementation likely attenuates delayed onset muscle soreness (DOMS). European Journal of Applied Physiology, 115, 1769–1777.

Nurenberg, P. (1992). MR imaging-guided muscle biopsy for correlation of increased signal intensity with ultrastructural change and delayed-onset muscle soreness after exercise. Radiology. 184(3), 865-869.

Priyadarsini, K.I. (2014). The chemistry of curcumin: from extraction to therapeutic agent. Molecules, 19(12), 20091-20112.

Roos, E. M. et al. (1998). Knee Injury and Osteoarthritis Outcome Score (KOOS)--development of a self-administered outcome measure. Journal of Orthopaedic & Sports Physical Therapy, 28(2), 88-96.

Takahashi, M. et al. (2014). Effects of Curcumin Supplementation on Exercise-Induced Oxidative Stress in Humans. Thieme Medical Publishers, 35(6), 469-475.

Tanabe, Y. et al. (2015). Attenuation of indirect markers of eccentric exercise-induced muscle damage by curcumin. European Journal of Applied Physiology, 115(9), 1949–1957.

Tanabe, Y. et al. (2019). Effects of oral curcumin ingested before or after eccentric exercise on markers of muscle damage and inflammation. John Wiley and Sons, 28, 1-11.



How to Cite

LIRA JÚNIOR, G. de A.; PEREIRA, D. E. . Antioxidant and anti-inflammatory effects of Turmeric and its impact on muscle damage induced by physical exercise: Is there a relationship?. Research, Society and Development, [S. l.], v. 12, n. 5, p. e4212541452, 2023. DOI: 10.33448/rsd-v12i5.41452. Disponível em: Acesso em: 13 apr. 2024.



Review Article