Dietary introduction of gluten and casein and risk to Autism Spectrum Disorder

Authors

DOI:

https://doi.org/10.33448/rsd-v13i1.44758

Keywords:

Autism Spectrum Disorder; Complementary feeding; Children; Glutens; Casein.

Abstract

Objective: To associate the period of dietary introduction of gluten and casein with the risk of Autism Spectrum Disorder (ASD). Methodology: Retrospective cohort study that investigated children’s exposure to the consumption of foods that are sources of gluten and casein in complementary foods, and the risk of ASD between 16 and 30 months of age. The M-CHAT-R questionnaire was used to assess the risk of ASD. Association was evaluated using chi-square test. Pearson’s correlation was used to correlate the month of gluten and casein introduction with M-CHAT-R score. Result: Twenty mother-child pairs participated, with a predominance of males (80%) among the children. Two children (10%) started eating gluten or casein before six months of age. No child was at a moderate or high risk of autism according to the M-CHAT-R. There was no association between the month of introduction of gluten and casein with the risk of developing ASD. There was also no association between the month of introduction of gluten (r = -0,213, p = 0,367) or casein (r = -0,117, p = 0,625) with the total score on the M-CHAT-R, however, there seems to be a trend indicating that early introduction is correlated with a higher score on the instrument, that is, risk of ASD. Conclusion: The period of dietary introduction of gluten and casein in complementary feeding for infants is not associated with the risk of developing ASD in children aged 16 to 30 months.

References

Aranburu, E., Matias, S., Simón, E., Larretxi, I., Martínez, O., Bustamante, M. Á. & Miranda, J. (2021). Gluten and FODMAPs Relationship with Mental Disorders: Systematic Review. Nutrients, 13(6):1894.

Buie, T., Campbell, D. B., Fuchs, G. J. 3rd., Furuta, G. T., Levy, J., Vandewater, J. & Winter, H. (2010). Evaluation, diagnosis, and treatment of gastrointestinal disorders in individuals with ASDs: a consensus report. Pediatrics, 125(1):1-18.

D'Eufemia, P., Celli, M., Finocchiaro, R., Pacifico, L., Viozzi, L., Zaccagnini, M. & Giardini, O. (1996). Abnormal intestinal permeability in children with autism. Acta Paediatr., 85(9):1076-9.

Elder, J. H., Shankar, M., Shuster, J., Theriaque, D., Burns, S. & Sherrill, L. (2006). The Gluten-Free, Casein-Free Diet In Autism: Results of A Preliminary Double Blind Clinical Trial. Journal of Autism and Developmental Disorders, 36(3):413–20.

Estrela, C. (2018). Metodologia Científica: Ciência, Ensino, Pesquisa. Editora Artes Médicas.

Freeman, B. J., Ritvo, E. R., Yokota, A. & Ritvo, A. (1986). A scale for rating symptoms of patients with the syndrome of autism in real-life settings. Journal of the American Academy of Child and Adolescent Psychiatry, 25(1): 131-136.

Fukudome, S., Jinsmaa, Y., Matsukawa, T., Sasaki, R. & Yoshikawa, M. (1997). Release of opioid peptides, gluten exorphins by the action of pancreatic elastase. FEBS Letters, 412(3):475–9.

Galiatsatos, P., Gologan, A. & Lamoureux, E. (2009). Autistic enterocolitis: Fact or fiction? Can J Gastroenterol., 23(2):95–8.

Ghalichi, F., Ghaemmaghami, J., Malek, A. & Ostadrahimi, A. (2016). Effect of gluten free diet on gastrointestinal and behavioral indices for children with autism spectrum disorders: a randomized clinical trial. World J Pediatr.,12(4):436-442.

Ghozy, S., Tran, L., Naveed, S., Quynh, T. T. H., Zayan, A. H., Waqas, A. & Huy, N. T. (2020). Association of breastfeeding status with risk of autism spectrum disorder: a systematic review, dose-response analysis and meta-analysis. Asian Journal of Psychiatry, 48:1876-2018.

González-Domenech, P. J., Diaz-Atienza, F., Gutiérrez-Rojas, L., Fernández-Soto, M. L., & González-Domenech, C. M. (2022). A Narrative Review about Autism Spectrum Disorders and Exclusion of Gluten and Casein from the Diet. Nutrients, 14(9), 1797.

Horvath, K., Papadimitriou, J.C., Rabsztyn, A., Drachenberg, C. & Tildon, J. T. (1999). Gastrointestinal abnormalities in children with autistic disorder. J Pediatr, 135(5):559-63.

Horvath, K. & Perman, J.A. (2002). Autism and gastrointestinal symptoms. Curr Gastroenterol Rep., 4(1): 251-8.

Hyman, S. L., Stewart, P. A., Foley, J., Cain, U., Peck, R., Morris, D. D. & Smith, T. (2016). The Gluten-Free/Casein-Free Diet: A Double-Blind Challenge Trial in Children with Autism. Journal of Autism and Developmental Disorders, 46:205-220.

Jarmołowska, B., Bukało, M., Fiedorowicz, E., Cieślińska, A., Kordulewska, N. K., Moszyńska, M. & Kostyra, E. (2019). Role of Milk-Derived Opioid Peptides and Proline Dipeptidyl Peptidase-4 in Autism Spectrum Disorders. Nutrients, 11(1):87.

Lange, K. W., Hauser, J. & Reissmann, A. (2015). Gluten-free and casein-free diets in the therapy of autism. Curr Opin Clin Nutr Metab Care., 18: 572-5.

Losapio, M.F. & Ponde, M. P. (2008). Tradução para o português da escala M-CHAT para rastreamento precoce de autismo. Rev Psiquiatr Rio Gd Sul, 30(3):221-9.

Matthews, J. S., & Adams, J. B. (2023). Ratings of the Effectiveness of 13 Therapeutic Diets for Autism Spectrum Disorder: Results of a National Survey. Journal of Personalized Medicine, 13(10), 1448–1448.

Marí-Bauset, S., Zazpe, I., Mari-Sanchis, A., Llopis-González, A. & Morales-Suárez-Varela, M. (2014) Evidence of the gluten-free and casein-free diet in autism spectrum disorders: a systematic review. J Child Neurol., 29(12):1718–27.

Mendive Dubourdieu, P., & Guerendiain, M. (2023). Understanding the link between gut microbiota, dietary intake, and nutritional status in children with autism and typical development. Frontiers in Nutrition, 10, 1202948.

Ozonoff, S., Strayer, D. L., McMahon, W. M. & Filloux, F. (1994). Executive functions abilities in autism and Tourette syndrome: an information processing approach. J Child Psychol Psychiatry., 35(1):1015-32.

Panksepp, J. (1979). A neurochemical theory of autism. Trends Neurosci., 2:174–177.

Parracho, H. M., Bingham, M. O., Gibson, G. R. & McCartney, A. L. (2005). Differences between the gut microflora of children with autistic spectrum disorders and that of healthy children. J Med Microbiol., 54(Pt 10):987-91.

Quan, L., Xu, X., Cui, Y., Han, H., Hendren, R. L., Zhao, L., & You, X. (2022). A systematic review and meta-analysis of the benefits of a gluten-free diet and/or casein-free diet for children with autism spectrum disorder. Nutrition Reviews, 80(5), 1237–1246.

Reichelt, K. L., Knivsberg, A. M., Lind, G. & Nødland, M. (1991). Probable etiology and possible treatment of childhood autism. Brain Dysfunction, 4(6):308–19.

Ristori, M. V., Quagliariello, A., Reddel, S., Ianiro, G., Vicari, S., Gasbarrini, A. & Putignani, L. (2019). Autism, Gastrointestinal Symptoms and Modulation of Gut Microbiota by Nutritional Interventions. Nutrients, 11(11):2812.

Robins, D., Fein, D., Barton, M. & Resegue, R. M. (2009). Trad. Questionário Modificado para a Triagem do Autismo em Crianças entre 16 e 30 meses, Revisado, com Entrevista de Seguimento (M-CHAT-R/F)TM. http://www.mchatscreen.com

Sahley, T. L. & Panksepp, J. (1987). Brain opioids and autism: An updated analysis of possible linkages. J Autism Dev Disord., 17(2): 201–16.

Salomone, E., Charman, T., McConachie, H., Warreyn, P.; Working Group 4 & COST Action ‘Enhancing the Scientific Study of Early Autism’. (2015). Prevalence and correlates of use of complementary and alternative medicine in children with autism spectrum disorder in Europe. Eur J Pediatr., 174(10):1277-85.

Samadi, S. A. & McConkey, R. (2014). The utility of the Gilliam autism rating scale for identifying Iranian children with autism. Disabil Rehabil, 36:452–456.

Sociedade Brasileira de Pediatria. (2017). Documento Científico: Rastreio Precoce para o Autismo / Transtorno do Espectro Autista. Belo Horizonte: SBP.

Sociedade Brasileira de Pediatria. (2018). Manual de Alimentação: orientações para alimentação do lactente ao adolescente, na escola, na gestante, na prevenção de doenças e segurança alimentar. Departamento Científico de Nutrologia. Rio de Janeiro: SBP.

Sociedade Brasileira de Pediatria (2019). Manual de Orientação: Transtorno do Espectro Autista. Departamento Científico de Pediatria do Desenvolvimento e Comportamento. Rio de Janeiro: SBP.

Sun, Z., Cade, J. R., Fregly, M. J. & Privette, R. M. (1999). β-Casomorphin Induces Fos-Like Immunoreactivity in Discrete Brain Regions Relevant to Schizophrenia and Autism. Autism., 3(1):67–83.

van De Sande, M. M., van Buul, V. J. & Brouns, F. J. P. H. (2014). Autism and nutrition: the role of the gut-brain axis. Nutr Res Rev., 27(2):199-214.

Wakefield, A. J., Anthony, A., Murch, S. H., Thomson, M., Montgomery, S. M., Davies, S. & Walker-Smith, J. A. (2000). Enterocolitis in children with developmental disorders. Am J Gastroenterol., 95(9):2285-95.

Whiteley, P., Shattock, P., Knivsberg, A. M., Seim, A., Reichelt, K. L., Todd, L., Carr, K. & Hooper, M. (2013). Gluten- and casein-free dietary intervention for autism spectrum conditions. Front Hum Neurosci., 6:344.

Word Health Organization (2019). Autism Spectrum Disorder. Geneva, Switzerland: WHO.

Zablotsky, B., Black, L. I. & Blumberg, S. J. (2017). Estimated Prevalence of Children With Diagnosed Developmental Disabilities in the United States, 2014-2016. NCHS Data Brief, (291):1–8.

Published

13/01/2024

How to Cite

SILVA, B. M. .; UED , F. da V. . Dietary introduction of gluten and casein and risk to Autism Spectrum Disorder . Research, Society and Development, [S. l.], v. 13, n. 1, p. e6213144758, 2024. DOI: 10.33448/rsd-v13i1.44758. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/44758. Acesso em: 30 may. 2024.

Issue

Section

Agrarian and Biological Sciences