Histamine-2 Receptor Antagonists and Proton Pump Inhibitors: Efficacy and drug prediletion in Stress Ulcer prophylaxis in patients admitted to the Pediatric Oncology ICU at Uopeccan Hospital

Authors

DOI:

https://doi.org/10.33448/rsd-v13i1.44829

Keywords:

Stress ulcer; Prophylaxis; ICU; Pediatrics.

Abstract

Objective: To analyze and obtain results for Stress Ulcer prophylaxis with Proton Pump Inhibitors and Histamine-2 Receptor Antagonists in a patient in the pediatric ICU. The objective of this study reviews the predilection, existence of criteria and prophylactic effectiveness of both. Methods: It is developed from a retrospective observational study composed of medical records/data collection from patients in the Pediatric Intensive Care Unit at Hospital Uopeccan of Cascavel, between January 2012 and January 2022. Data relating to gender, age, diagnosis, reason for hospitalization, length of stay in the ICU and choice of gastric protector. Results: 43 cases of patients admitted to the ICU during the stipulated period were analyzed. Of these, the average age of patients in the research carried out was 4 years and 5 months, with 39.53% (n=17) female and 60.46% (n=26) male with an average hospitalization of approximately 10,6 days. Approximately 94.28% (n=33) of patients received some type of prophylactic, and within this percentage, 91.42% (n=32) of cases used PPI, 2.85% (n=1) ARH2 and 5.71% (n=2) did not use any medication. Conclusion: Based on this study, it is possible to conclude that there is a lack of scientific evidence and comprehensive research related to Proton Pump Inhibitors (PPI) and Histamine 2 Receptor Antagonists (ARH2) in clinical practice. This information gap may represent a potential disadvantage for patients, given the lack of specific criteria for Stress Ulcer prophylaxis in Pediatric Intensive Care Centers.

References

Abu El-Ella, S. S., El-Mekkawy, M. S., & Mohamed Selim, A. (2022). Stress ulcer prophylaxis for critically ill children: routine use needs to be re-examined. Anales de Pediatría (English Edition), 96(5), 402–409. https://doi.org/10.1016/j.anpede.2021.03.001

Araujo, T. E., Vieira, S. M. G., & Carvalho, P. R. A. (2010). Stress ulcer prophylaxis in pediatric intensive care units. Jornal de pediatria, 86(6), 525–530. https://doi.org/10.2223/jped.2046

Barbateskovic, M., Marker, S., Granholm, A., Anthon, C. T., Krag, M., Jakobsen, J. C., Perner, A., Wetterslev, J., & Møller, M. H. (2019). Stress ulcer prophylaxis with proton pump inhibitors or histamin-2 receptor antagonists in adult intensive care patients: a systematic review with meta-analysis and trial sequential analysis. Intensive Care Medicine, 45(2), 143–158. https://doi.org/10.1007/s00134-019-05526-z

Brown, K. E., Knoderer, C. A., Nichols, K. R., & Crumby, A. S. (2015). Acid-suppressing agents and risk for Clostridium difficile infection in pediatric patients. Clinical Pediatrics, 54(11), 1102–1106. https://doi.org/10.1177/0009922815569201

Buendgens, L. (2016). Prevention of stress-related ulcer bleeding at the intensive care unit: Risks and benefits of stress ulcer prophylaxis. World Journal of Critical Care Medicine, 5(1), 57. https://doi.org/10.5492/wjccm.v5.i1.57

Camargo, L. M. A., Silva, R. P. M., & Meneguetti, D. U. D. O. (2019). Research methodology topics: Cohort studies or prospective and retrospective cohort studies. Journal of Human Growth and Development, 29(3), 433–436. https://doi.org/10.7322/jhgd.v29.9543

Castro, R. E. V. de, Sousa, C. da C., de Magalhães-Barbosa, M. C., Prata-Barbosa, A., & Cheniaux, E. (2019). Ranitidine-induced delirium in a 7-year-old girl: A case report. Pediatrics, 143(2). https://doi.org/10.1542/peds.2018-2428

Cook, D. J., Fuller, H. D., Guyatt, G. H., Marshall, J. C., Leasa, D., Hall, R., Winton, T. L., Rutledge, F., Todd, T., Roy, P., Lacroix, J., Griffith, L., & Willan, A. (1994). Risk factors for gastrointestinal bleeding in critically ill patients. The New England Journal of Medicine, 330(6), 377–381. https://doi.org/10.1056/nejm199402103300601

Fisiopatologia, 1. Definição E. Profilaxia de Úlcera por Estresse. Einstein.br. https://medicalsuite.einstein.br/pratica-medica/Pathways/Profilaxia-de-ulcera-por-estresse.pdf

Freitas, D., Araújo, K., Gonçalves, M., Nascimento, G., & Kassar, S. (2021). Indications of gastric ulcer prophylaxis in hospitalized pediatric patients: an integrative review. Residência Pediátrica, 11(3). https://doi.org/10.25060/residpediatr-2021.v11n3-230

Machado, A. S., & Teixeira, C. (2006). Profilaxia para úlcera de estresse nas unidades de terapia intensiva: estudo observacional multicêntrico. Revista Brasileira de Terapia Intensiva, 18(3), 229–233. https://doi.org/10.1590/s0103-507x2006000300003

Mendes, J. J., Silva, M. J., Miguel, L. S., Gonçalves, M. A., Oliveira, M. J., Oliveira, C. da L., & Gouveia, J. (2019). Sociedade Portuguesa de Cuidados Intensivos guidelines for stress ulcer prophylaxis in the intensive care unit. Revista Brasileira de Terapia Intensiva, 31(1), 5–14. https://doi.org/10.5935/0103-507x.20190002

Morgan, D. J., Dhruva, S. S., Coon, E. R., Wright, S. M., & Korenstein, D. (2019). 2019 update on medical overuse: A review. JAMA Internal Medicine, 179(11), 1568. https://doi.org/10.1001/jamainternmed.2019.3842

Newberry, C., & Schucht, J. (2018). Use of enteral nutrition for gastrointestinal bleeding prophylaxis in the critically ill: Review of current literature. Current Nutrition Reports, 7(3), 116–120. https://doi.org/10.1007/s13668-018-0232-3

Pompilio, C. E., & Cecconello, I. (2010). Profilaxia das úlceras associadas ao estresse. Arquivos brasileiros de cirurgia digestiva [Brazilian archives of digestive surgery], 23(2), 114–117. https://doi.org/10.1590/s0102-67202010000200011

Santana, R. N. S., Santos, V. S., Ribeiro-Júnior, R. F., Freire, M. S., Menezes, M. A. S., Cipolotti, R., & Gurgel, R. Q. (2017). Use of ranitidine is associated with infections in newborns hospitalized in a neonatal intensive care unit: a cohort study. BMC Infectious Diseases, 17(1). https://doi.org/10.1186/s12879-017-2482-x

Santana, T. D. B., Mascarenhas, A. M. S., Lopes, D. S., Santos, N. J. S. dos, & Lemos, G. da S. (2023). Profilaxia medicamentosa de lesão aguda da mucosa gástrica: revisão sistemática. Research, Society and Development, 12(4), e13312441071. https://doi.org/10.33448/rsd-v12i4.41071

Silva, R. F. da, Santos, S. L. dos, Afonso, T. de O., Silva, F. P. da, Ribeiro, S. de S. C., Gama, S. M. B. da C., Fonseca, S. da S. S., Leite, A. C., Sousa, M. da C. V., Barbosa, M. F. L., Pessôa, F. G. de S., Barros, G. M. de, Carvalho, F. R. de, Silva, A. B. da, Oliveira, W. K. S., Silva, R. S. C., & Maciel, A. C. (2021). Profilaxia para úlcera de estresse na Unidade de Terapia Intensiva: uma revisão integrativa. Research, Society and Development, 10(10), e500101019001. https://doi.org/10.33448/rsd-v10i10.19001

Trifan, A., Stanciu, C., Girleanu, I., Stoica, O. C., Singeap, A. M., Maxim, R., Chiriac, S. A., Ciobica, A., & Boiculese, L. (2017). Proton pump inhibitors therapy and risk of Clostridium difficile infection: Systematic review and meta-analysis. World Journal of Gastroenterology: WJG, 23(35), 6500–6515. https://doi.org/10.3748/wjg.v23.i35.6500

Published

21/01/2024

How to Cite

ABE, N. L. de M. .; FIORI, C. M. C. M. .; MICHELON, I. C. .; SILVA, L. M. G. da .; SEIBERT, J. M. . Histamine-2 Receptor Antagonists and Proton Pump Inhibitors: Efficacy and drug prediletion in Stress Ulcer prophylaxis in patients admitted to the Pediatric Oncology ICU at Uopeccan Hospital. Research, Society and Development, [S. l.], v. 13, n. 1, p. e9813144829, 2024. DOI: 10.33448/rsd-v13i1.44829. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/44829. Acesso em: 30 may. 2024.

Issue

Section

Health Sciences