Omega 3 in reducing disease and increasing longevity: A literature review

Authors

DOI:

https://doi.org/10.33448/rsd-v13i3.45408

Keywords:

Omega-3, Fatty Acids; Longevity; Dietary supplements.

Abstract

The present study presents a literature review on omega-3 fatty acids and their impact on health and longevity. Due to the increased interest in health promotion and healthy aging, omega-3 fatty acids have gained a large role in society due to their diverse benefits. These acids, not synthesized by the body, are acquired from the diet and stand out for their anti-inflammatory, cardiovascular and neuroprotective effects, making them promising targets for nutritional interventions. The review analyzed 58 articles over the last 5 years, using the National Library of Medicine (PubMed) database. The results reveal that omega-3 is associated with a reduced risk of cardiovascular disease, with beneficial effects on blood pressure, triglycerides and endothelial function. Furthermore, they demonstrate powerful anti- inflammatory effects, even influencing conditions such as rheumatoid arthritis and cancer. In the nervous system, it stands out for its neuroprotective effects, related to the prevention of neurodegenerative diseases and cognitive improvement. Although benefits for bone health were observed, the review highlights the need for more research, recognizing limitations in studies such as heterogeneity in research methods. The direct relationship between omega-3 and longevity demands specific, long-term investigations. In conclusion, this article highlights omega-3 as a promising intervention for promoting health and increasing longevity, suggesting its inclusion in the diet, but highlighting the continued importance of research to consolidate these findings.

References

Agusti, A., Barbé, F., Tura-Ceide, O., Pascual, S., Gabasa, M., Catapano, A. L., Vidal, M., García-Rio, F., & Faner, R. (2019). Omega-3 polyunsaturated fatty acid supplementation improves postabsorptive and prandial protein metabolism in patients with chronic obstructive pulmonary disease: A randomized clinical trial. Clinical Nutrition, 38(4), 1593–1601. https://doi.org/10.1016/j.clnu.2018.08.012

Barardo, D., Thornton, D., Thoppil, H., Walsh, M., Sharifi, S., Ferreira, S., Anžič, A., Fernandes, M., Monteiro, P., Grum, T., Cordeiro, R., De-Souza, E. A., Budovsky, A., Araujo, N., Gruber, J., Petrascheck, M., Fraifeld, V. E., Zhavoronkov, A., & de Magalhães, J. P. (2019). Investigational drugs and nutrients for human longevity. Recent clinical trials registered in ClinicalTrials.gov and clinicaltrialsregister.eu. Ageing Research Reviews, 49, 88–103. https://doi.org/10.1016/j.arr.2018.11.004

Beard, J., & Unger, E. (2019). Maternal pyrroloquinoline quinone supplementation improves offspring liver bioactive lipid profiles throughout the lifespan and protects against the development of adult NAFLD. International Journal of Molecular Sciences, 20(5), 1015. https://doi.org/10.3390/ijms20051015

Bell, M. T., Puskás, L. G., & Duffield, M. D. (2019). The second phase of brain trauma can be controlled by nutraceuticals that suppress DAMP-mediated microglial activation. Neural Regeneration Research, 14(9), 1484–1485. https://doi.org/10.4103/1673-5374.255966

Blanco-Colio, L. M., Martín-Ventura, J. L., & Gómez-Hernández, A. (2019). [Nutrition and mental disorders during the life span: An overview of scientific evidence]. Actas Españolas de Psiquiatría, 47(2), 56–63. https://www.actaspsiquiatria.es/repositorio/20/104/ENG/20-104-ENG-56-63-1304741.pdf

Canto, C., Menzies, K. J., & Auwerx, J. (2015). Polyunsaturated fatty acids and p38-MAPK link metabolic reprogramming to cytoprotective gene expression during dietary restriction. BioEssays, 37(4), 367–376. https://doi.org/10.1002/bies.201400183

Carvalho, M., Ferreira, R., Mendes, V., Silva, R., Pereira, M., Valença, I., Amaral, J. S., Vasconcelos, V., & Martins, L. L. (2017). Juniperonic acid biosynthesis is essential in Caenorhabditis elegans lacking delta6 desaturase (fat-3) and generates new omega-3 endocannabinoids. Biochimie Open, 5, 125–132. https://doi.org/10.1016/j.biopen.2017.04.002

Castro-Barquero, S., Tresserra-Rimbau, A., Vitelli-Storelli, F., Domenech, M., Salas-Salvadó, J., Martín-Sánchez, V., & Rubín-García, M. (2020). The effects of the Mediterranean diet on health and gut microbiota. The Journal of Nutrition, 150(8), 1856–1867. https://doi.org/10.1093/jn/nxaa094

Chen, C. T., Kitson, A. P., Hopperton, K. E., Domenichiello, A. F., Trépanier, M. O., Lin, L. E., Ermini, L., Post, M., Thies, F., Bazinet, R. P., & Anderson, G. J. (2015). Docosahexaenoic acid (DHA) supplementation alters phospholipid species and lipid peroxidation products in adult mouse brain, heart, and plasma. Journal of Nutritional Biochemistry, 21(10), 940–947. https://doi.org/10

Demaria, M., & Campisi, J. (2018). Nutraceuticals-based immunotherapeutic concepts and opportunities for the mitigation of cellular senescence and aging: A narrative review. AGING, 10(2), 208–219. https://doi.org/10.18632/aging.101382

Deldicque, L., Theisen, D., Francaux, M., & Hespel, P. (2019). Human skeletal muscle metabolic responses to 6 days of high-fat overfeeding are associated with dietary n-3PUFA content and muscle oxidative capacity. Physiological Reports, 7(16), e14268. https://doi.org/10.14814/phy2.14268

Di Pasquale, M., Sajic, M., Vincent, A. J., Barrett, M., Ramracheya, R., & Harper, A. G. S. (2019). Effect of diet lipids and omega-6:3 ratio on honey bee brood development, adult survival and body composition. Journal of Experimental Biology, 222(1), jeb184192. https://doi.org/10.1242/jeb.184192

Dawson-Hughes, B., Stoecklin, E., Peacock, M., Shearer, M. J., & Wolf, R. L. (2019). DO-HEALTH: Vitamin D3 - Omega-3 - Home exercise - Healthy aging and longevity trial - Design of a multinational clinical trial on healthy aging among European seniors. Contemporary Clinical Trials, 76, 57–63. https://doi.org/10.1016/j.cct.2018.12.001

Farzaneh-Far, R., Lin, J., Epel, E., Lapham, K., Blackburn, E., Whooley, M. A., & Blackburn, E. H. (2010). Effect of omega-3 fatty acid supplementation on telomere length and telomerase activity: A systematic review of clinical trials. Brain, Behavior, and Immunity, 25(8), 1725–1734. https://doi.org/10.1016/j.bbi.2010.07.226

Franco, R., Navarro, G., Martínez-Pinilla, E., & García-Merino, A. (2017). Nutraceuticals targeting generation and oxidant activity of peroxynitrite may aid prevention and control of Parkinson's disease. Current Drug Metabolism, 18(6), 597–609. https://doi.org/10.2174/1389200218666170105122507

Franco, R., Navarro, G., Martínez-Pinilla, E., & García-Merino, A. (2017). Nutraceuticals targeting generation and oxidant activity of peroxynitrite may aid prevention and control of Parkinson's disease. Current Drug Metabolism, 18(6), 597–609. https://doi.org/10.2174/1389200218666170105122507

García-Calzón, S., Moleres, A., Martínez-González, M. A., Martínez, J. A., & Zalba, G. (2019). Epigenome-wide association study of dietary fatty acid intake. Journal of Nutritional Biochemistry, 65, 71–76. https://doi.org/10.1016/j.jnutbio.2018.10.007

Ginty, A. T., Conklin, S. M., & Short, K. R. (2018). Development and validation of a HPLC-MS/MS method for the analysis of fatty acids - in the form of FAME ammonium adducts - in human whole blood and erythrocytes to determine omega-3 index. Journal of Chromatography B, 1096, 172–178. https://doi.org/10.1016/j.jchromb.2018.07.019

Heffernan, A. L., Chidgey, C., Peng, P., Masters, C. L., & Roberts, B. R. (2016). Midlife omega-3 fatty acid intake predicts later life white matter microstructure in an age- and APOE-dependent manner. Frontiers in Aging Neuroscience, 8, Article 273. https://doi.org/10.3389/fnagi.2016.00273

Ho, N., Feng, J. A., & Artinian, N. T. (2020). Improving cognitive function with nutritional supplements in aging: A comprehensive narrative review of clinical studies investigating the effects of vitamins, minerals, antioxidants, and other dietary supplements. Nutrition and Aging, 6(3–4), 215–229. https://doi.org/10.3233/NHA-190067

Li, D., Zhang, D., & Sinclair, A. (2020). Multiple health benefits and minimal risks associated with vegetarian diets. Nutrients, 12(1), 9. https://doi.org/10.3390/nu12010009

Lu, A. T., & Raj, K. (2019). DNA methylation GrimAge strongly predicts lifespan and healthspan. Aging, 11(2), 303–307. https://doi.org/10.18632/aging.101684

Martínez-Lapiscina, E. H., & Hu, F. B. (2019). Impact of nut consumption on cognition across the lifespan. Nutritional Neuroscience, 22(10), 683–688. https://doi.org/10.1080/1028415X.2017.1411871

Martorell-Marugán, J., Villatoro-García, J. A., & Carmona-Sáez, P. (2019). The socioeconomic landscape of the exposome during pregnancy. Environmental Research, 174, 94–105. https://doi.org/10.1016/j.envres.2019.03.053

Miles, E. A., & Calder, P. C. (2018). Unsaturated fatty acids and their immunomodulatory properties. Prostaglandins, Leukotrienes and Essential Fatty Acids, 132, 41–48. https://doi.org/10.1016/j.plefa.2017.12.002

Moghadam, A. R., Tutunchi, H., Namvaran-Abbas-Abad, A., Jameie, S. B., & Sahebkar, A. (2018). Nutraceutical strategies for alleviation of UVB phototoxicity. Dermatologic Therapy, 31(5), e12695. https://doi.org/10.1111/dth.12695

O'Flanagan, C. H., Smith, L. A., McDonell, S. B., & Hursting, S. D. (2019). Nutraceutical targeting of TLR4 signaling has potential for prevention of cancer cachexia. Nutrition and Cancer, 71(6), 881–888. https://doi.org/10.1080/01635581.2018.1530506

Patel, S., & Rauf, A. (2017). Dietary fats, blood pressure and artery health. Lipids in Health and Disease, 16(1), 172. https://doi.org/10.1186/s12944-017-0567- 5

Rankin, N. J., Preiss, D., Welsh, P., Burgess, K. E. V., Nelson, S. M., Lawlor, D. A., Sattar, N., & McConnachie, A. (2020). Metabolic biomarkers using nuclear magnetic resonance metabolomics assay for the prediction of aging-related disease risk and mortality: A prospective, longitudinal, observational, cohort study based on the UK Biobank. The Journals of Gerontology: Series A, 75(2), 273–282. https://doi.org/10.1093/gerona/glz167

Richardson, T. G., Sanderson, E., Palmer, T. M., Ala-Korpela, M., & Ference, B. A. (2020). Causal associations between polyunsaturated fatty acids and kidney function: A bidirectional Mendelian randomization study. Journal of the American Society of Nephrology, 31(6), 1242–1251. https://doi.org/10.1681/ASN.2019080841

Robinson, S. M., Reginster, J. Y., Rizzoli, R., Shaw, S. C., Kanis, J. A., Bautmans, I., Bischoff-Ferrari, H., Bruyère, O., Cesari, M., Dawson-Hughes, B., Fielding, R. A., Kaufman, J. M., Landi, F., Malafarina, V., Maier, A. B., Reginster, J. Y., Rolland, Y., van Loon, L. J. C., Vellas, B., & Cooper, C. (2018). The effect of nutrition on aging-A systematic review focusing on aging-related biomarkers. Advances in Nutrition, 9(6), 996–1004. https://doi.org/10.1093/advances/nmy058

Rubín-García, M., Sánchez-Quesada, C., Blanco-Carnero, J. E., López-Sabater, M. C., Gheorghe, A., Stiris, T., Cetin, I., Koletzko, B. V., Schmelzle, H., Palmeira, A. L., Szajewska, H., van Goudoever, J. B., Koletzko, S., Campoy, C., & Demmelmair, H. (2019). Impact of the Mediterranean dietary pattern on n- 3 fatty acid tissue levels-A systematic review. Nutrients, 11(9), 2273. https://doi.org/10.3390/nu11092273

Scragg, R. K., Genuis, S. J., Rowley, K. G., & Kruger, M. C. (2017). PUFA omega-3 and omega-6 biomarkers and sleep: A pooled analysis of cohort studies on behalf of the Fatty Acids and Outcomes Research Consortium (FORCE). Sleep Medicine Reviews, 33, 71–82. https://doi.org/10.1016/j.smrv.2016.05.001

Sekikawa, A., Curb, J. D., Ueshima, H., El-Saed, A., Kadowaki, T., Abbott, R. D., Evans, R. W., Rodriguez, B. L., Okamura, T., Sutton-Tyrrell, K., Nakamura, Y., Masaki, K., Edmundowicz, D., Kashiwagi, A., Willcox, B. J., Takamiya, T., Mitsunami, K., Seto, T. B., Murata, K., & Kuller, L. H. (2015). Effects of eicosapentaenoic acid on serum levels of selenoprotein P and organ-specific insulin sensitivity in humans with dyslipidemia and type 2 diabetes. Metabolism, 64(12), 1610–1617. https://doi.org/10.1016/j.metabol.2015.08.014

Tsubota-Utsugi, M., Satoh, M., & Kadota, A. (2019). Fish and meat intake, serum eicosapentaenoic acid and docosahexaenoic acid levels, and mortality in community-dwelling Japanese older persons. International Journal of Environmental Research and Public Health, 16(20), 4004. https://doi.org/10.3390/ijerph16204004

Ufnal, M., Zadlo, A., & Ostaszewski, R. (2015). Association of moderately elevated trimethylamine N-oxide with cardiovascular risk: Is TMAO serving as a marker for hepatic insulin resistance? Journal of Clinical Medicine, 4(10), 1930–1941. https://doi.org/10.3390/jcm4101930

Varga, T., & Mounier, R. (2019). Dynamic changes to lipid mediators support transitions among macrophage subtypes during muscle regeneration. Frontiers in Immunology, 10, Article 41. https://doi.org/10.3389/fimmu.2019.00041

Volpi, E., Campbell, W. W., & Dreyer, H. C. (2018). Nutraceuticals and their role in promoting musculo-skeletal healthy aging. Current Opinion in Clinical Nutrition and Metabolic Care, 21(3), 155–162. https://doi.org/10.1097/MCO.0000000000000452

Wu, J. H. Y., Lemaitre, R. N., King, I. B., Song, X., Psaty, B. M., Siscovick, D. S., & Mozaffarian, D. (2012). Current evidence on dietary intakes of fatty acids and mortality. European Journal of Clinical Nutrition, 66(9), 994–1000. https://doi.org/10.1038/ejcn.2012.86

Yan, J., Chen, Y., & Gao, Z. (2019). Krill oil protects dopaminergic neurons from age-related degeneration through temporal transcriptome rewiring and suppression of several hallmarks of aging. Geroscience, 41(4), 419–448. https://doi.org/10.1007/s11357-019-00074-2

Ye, J., Wang, Y., Liu, X., Gao, Y., Liu, F., Li, X., Zhang, M., Song, Z., & Jin, W. (2021). Impact of nutraceuticals on markers of systemic inflammation: Potential relevance to cardiovascular diseases - A position paper from the International Lipid Expert Panel (ILEP). Pharmacological Research, 166, 105430. https://doi.org/10.1016/j.phrs.2021.105430

Yan, J., Chen, Y., & Gao, Z. (2019). Krill oil protects dopaminergic neurons from age-related degeneration through temporal transcriptome rewiring and suppression of several hallmarks of aging. Geroscience, 41(4), 419–448. https://doi.org/10.1007/s11357-019-00074-2

Yang, X., & Li, L. (2019). Analytical methods for the determination of fatty acids and their 4-hydroxyalkenal derivatives in biomatrices: A review. Analytica Chimica Acta, 1055, 1–17. https://doi.org/10.1016/j.aca.2018.12.061

Ye, J., Wang, Y., Liu, X., Gao, Y., Liu, F., Li, X., Zhang, M., Song, Z., & Jin, W. (2021). Impact of nutraceuticals on markers of systemic inflammation: Potential relevance to cardiovascular diseases - A position paper from the International Lipid Expert Panel (ILEP). Pharmacological Research, 166, 105430. https://doi.org/10.1016/j.phrs.2021.105430

Yeganeh, P. R., & Leahy, S. (2018). Saturated fatty acids contribute to obesity via CD36-mediated macrophage infiltration into adipose tissue. International Journal of Obesity, 42(2), 257–264. https://doi.org/10.1038/ijo.2017.262

Yu, H., Chaimbault, P., & Perrin, C. (2019). Recent advances in the analysis of polyunsaturated fatty acids and oxylipins. TrAC Trends in Analytical Chemistry, 112, 94–105. https://doi.org/10.1016/j.trac.2018.12.018

Yu, H., Li, Q., Kolosov, V. P., & Peréz-Stable, C. (2020). Liquid chromatography coupled with mass spectrometry-based metabolomics for elucidating physiological and pathological roles of lipid metabolism: A review. Analytica Chimica Acta, 1127, 134–147. https://doi.org/10.1016/j.aca.2020.06.010

Zhang, J., Rane, G., Dai, X., Shanmugam, M. K., Arfuso, F., Samy, R. P., Lai, M. K. P., Kappei, D., Kumar, A. P., Sethi, G., & Warrier, S. (2016). Lifelong docosahexaenoic acid intervention ameliorates aging in the telomere-DNA-mitochondria axis in telomerase-deficient mice. Aging Cell, 15(3), 694–705. https://doi.org/10.1111/acel.12467

Zhang, X., Uchiyama, K., Ueno, M., Iida, M., Nakamura, M., Sakamoto, T., Muramatsu, Y., Watanabe, T., Suzuki, S., Ishizawa, K., Nomura, A., & Nakano, T. (2020). Measuring muscle protein synthesis in humans and the influence of nutritional state. Physiological Reports, 8(9), e14400. https://doi.org/10.14814/phy2.14400

Zheng, Z., Dai, Z., Jin, M., Li, D., Lin, M., Wang, L., Yu, M., Qi, X., & Zhou, L. (2020). Changes in the eicosapentaenoic acid to arachidonic acid ratio in serum over 10 years in a Japanese community: The Hisayama Study. Nutrition, Metabolism, and Cardiovascular Diseases, 30(4), 678–684. https://doi.org/10.1016/j.numecd.2019.11.011

Zheng, Z., Dai, Z., Jin, M., Lin, M., Wang, L., Yu, M., Qi, X., & Zhou, L. (2020). Plasma polyunsaturated fatty acid concentrations and sleep apnea risk: A two- sample Mendelian randomization study. Nutrition, Metabolism, and Cardiovascular Diseases, 30(4), 718–724. https://doi.org/10.1016/j.numecd.2019.11.010

Zhou, J., Su, L., Liu, M., Liu, Y., Cao, X., & Wang, Z. (2021). The association between first-trimester omega-3 fatty acid supplementation and fetal growth trajectories. Reproductive Sciences, 28(3), 877–884. https://doi.org/10.1007/s43032-020-00359-7

Zhou, Y., Xu, J., Hou, N., Yang, X., Sun, H., Li, L., & Sun, Z. (2019). Plasma phospholipid polyunsaturated fatty acids composition in early pregnancy and fetal growth trajectories throughout pregnancy: Findings from the US fetal growth studies-singletons cohort. Nutrients, 11(11), 2692. https://doi.org/10.3390/nu11112692

Zlokovic, B. V. (2011). Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Nature Reviews Neuroscience, 12(12), 723– 738. https://doi.org/10.1038/nrn3114

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29/03/2024

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SANTOS, L. H. C. dos .; FERRAZ, G. H. C. F. .; GAZOLA, L. M. S. .; CAVALCANTI, J. C. A. de M. .; FALCÃO, T. B. .; ARAÚJO , J. C. de A. .; PALÁCIO , E. M. .; PADILHA , M. V. C. .; FALCÃO, D. W. A. .; SANTOS III, A. C. dos .; ARAÚJO , M. F. C. de . Omega 3 in reducing disease and increasing longevity: A literature review. Research, Society and Development, [S. l.], v. 13, n. 3, p. e11613345408, 2024. DOI: 10.33448/rsd-v13i3.45408. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/45408. Acesso em: 14 nov. 2024.

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Vol. 13 No. 3

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Health Sciences

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Copyright (c) 2024 Luiz Henrique Cunha dos Santos; Graças Hermínia Cavalcanti França Ferraz; Laura Menezes Silva Gazola; Juliana Caroliny Araujo de Morais Cavalcanti; Thiago Barros Falcão; Jônica Cristina de Arruda Araújo ; Eduardo Marques Palácio ; Mariana Valença Collier Padilha ; Débora Wanderley Albanez Falcão; Amaro Capistrano dos Santos III; Mariana Ferraz Corrêa de Araújo

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