Incidental finding of beta thalassemia in a patient with high obstetric risk
DOI:
https://doi.org/10.33448/rsd-v13i8.46124Keywords:
Anemia; Beta thalassemia; Hemoglobin; Blood proteins electrophoresis; Pregnancy.Abstract
Thalassemia is a set of genetic anomalies produced by an inadequate hemoglobin synthesis, the illness rank goes from symptomatology to fetal death. This case was studied and its main target includes to highlight clinical aspects, diagnosis treatment and patient´s quality of life. Data was gathered from patient´s medical record and the NCBI served as reference source. The patients presents anemia with hemoglobin deficiency, hematocrit, VCM, HCM, and CHCM. The total serum iron levels and saturation percentage are markedly diminished. Besides the high resolution capillary electrophoresis indicates an abnormal pattern with suggestive bands of beta thalassemia. In the week 32, a fetal growth control ultrasound detected a profile disturbance with a Doppler study abnormal placental fetus. The diagnosis indicates intrauterine growth restriction phase 1 and the gestation has to be ended in the week 37. The neonatal result is and under weight new born. These kind of patients require a multidisciplinary approach that includes an exhaustive monitoring, a personalizad prenatal care and careful child birth planification.
References
Abid, S. J., & Najim, I. J. (2023). The prevalence of undiagnosed thalassemia minor among primigravida pregnant women before 20 weeks of gestation. Journal of Advanced Pharmaceutical Technology & Research, 14(3). https://journals.lww.com/japtr/fulltext/2023/14030/the_prevalence_of_undiagnosed_thalassemia_minor.20.aspx
Abu-Shaheen, A., Heena, H., Nofal, A., Abdelmoety, D. A., Almatary, A., Alsheef, M., & AlFayyad, I. (2020). Epidemiology of Thalassemia in Gulf Cooperation Council Countries: A Systematic Review. BioMed Research International, 2020, 1-15. https://doi.org/10.1155/2020/1509501
Aixalá, M. T. F. (2017). Anemia microcítica-hipocrómica: anemia ferropénica versus b talasemia menor. Acta Bioquímica Clínica Latinoamericana, 51(3), 291-305. https://www.redalyc.org/articulo.oa?id=53553013004
Alli, N. A., Patel, H. M., Pool, J., Goga, Y., & Krause, A. (2021). Thalassaemia (part 1). South African Medical Journal, 111(6), 529-534. https://doi.org/10.7196/SAMJ.2021.v111i6.15724
Amooee, S., Samsami, A., Jahanbakhsh, J., & Karimi, M. (2011). The pregnancy outcome in patients with minor β-thalassemia. En Iranian Journal of Reproductive Medicine (Vol. 9, Número 1).
Anuruksuwan, P., Sirilert, S., Luewan, S., & Tongsong, T. (2024). Impacts of β-thalassemia/hemoglobin E disease on pregnancy outcomes. International Journal of Gynecology & Obstetrics, n/a(n/a). https://doi.org/https://doi.org/10.1002/ijgo.15360
Carrara, J., Habibi, A., Benachi, A., & Cheminet, G. (2023). Sickle cell disease and pregnancy. La Presse Médicale, 52(4), 104203. https://doi.org/10.1016/J.LPM.2023.104203
Farmakis, D., Porter, J., Taher, A., Domenica Cappellini, M., Angastiniotis, M., Eleftheriou, A., & Taskforce*, for the 2021 T. I. F. G. (2022). 2021 Thalassaemia International Federation Guidelines for the Management of Transfusion-dependent Thalassemia. HemaSphere, 6(8). https://journals.lww.com/hemasphere/fulltext/2022/08000/2021_thalassaemia_international_federation.6.aspx
Hokland, P., Daar, S., Khair, W., Sheth, S., Taher, A. T., Torti, L., Hantaweepant, C., & Rund, D. (2023). Thalassaemia—A global view. British Journal of Haematology, 201(2), 199-214. https://doi.org/https://doi.org/10.1111/bjh.18671
Kattamis, A., Forni, G. L., Aydinok, Y., & Viprakasit, V. (2020). Changing patterns in the epidemiology of β‐thalassemia. European Journal of Haematology, 105(6), 692-703. https://doi.org/10.1111/ejh.13512
Kattamis, A., Kwiatkowski, J. L., & Aydinok, Y. (2022). Thalassaemia. The Lancet, 399(10343), 2310-2324. https://doi.org/10.1016/S0140-6736(22)00536-0
Kumar, V., Abbas, A. K., & Aster, J. C. (2021). Robbins Y Cotran. Patología Estructural Y Funcional (10.a ed.). Elsevier Health Sciences.
Lao, T. T. (2017). Obstetric care for women with thalassemia. Best Practice & Research Clinical Obstetrics & Gynaecology, 39, 89-100. https://doi.org/10.1016/J.BPOBGYN.2016.09.002
Leung, T. Y., & Lao, T. T. (2012). Thalassaemia in pregnancy. Best Practice & Research Clinical Obstetrics & Gynaecology, 26(1), 37-51. https://doi.org/10.1016/J.BPOBGYN.2011.10.009
Luk’yanenko, V., Droogh, M., Ulrik, &, & Overgaard, M. (2017). Talassaemier og graviditet. https://ugeskriftet.dk/videnskab/talassaemier-og-graviditet
Mohammed, E. A., & Muhammed, N. A. (2023). Effect of Maternal Beta-Thalassemia Minor on Obstetrical and Neonatal Outcomes in Kirkuk Province, Iraq. Al- Anbar Medical Journal, 19(2), 135-140. https://doi.org/10.33091/amj.2023.140349.1155
Ruangvutilert, P., Phatihattakorn, C., Yaiyiam, C., & Panchalee, T. (2023). Pregnancy outcomes among women affected with thalassemia traits. Archives of Gynecology and Obstetrics, 307(2), 431-438. https://doi.org/10.1007/s00404-022-06519-y
Shah, F. T., Nicolle, S., Garg, M., Pancham, S., Lieberman, G., Anthony, K., & Mensah, A. K. (2024). Guideline for the Management of Conception and Pregnancy in Thalassaemia Syndromes: A British Society for Haematology Guideline. British Journal of Haematology, n/a(n/a). https://doi.org/https://doi.org/10.1111/bjh.19362
Vlachodimitropoulou, E., Mogharbel, H., Kuo, K. H. M., Hwang, M., Ward, R., Shehata, N., & Malinowski, A. K. (2024). Pregnancy outcomes and iron status in β-thalassemia major and intermedia: a systematic review and meta-analysis. Blood Advances, 8(3), 746-757. https://doi.org/10.1182/bloodadvances.2023011636
Wu, L.-S., Luo, X., Tan, M., Zhang, L.-J., Luo, H.-F., Huang, G., Huang, P., Chen, J., & Chen, Y. (2024). Prevalence of thalassemia-carrier couples and fertility risk assessment. International Journal of Hematology, 119(4), 374-382. https://doi.org/10.1007/s12185-024-03722-2
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Copyright (c) 2024 Diego Fernando Lopez Muñoz; Daniela Andrea Agudelo Valencia; Oscar Eduardo Cruz Becerra; Sergio Ramirez Muñoz; Manuela Sanchez Escobar; Thana Manuella Trivino Montoya; Maria Alejandra Cifuentes Muñoz
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