The relationship of omega-3 in the prognosis of depression in adults: Integrative review
DOI:
https://doi.org/10.33448/rsd-v13i11.47350Keywords:
Fatty acids; Omega-3; Depression; Adult.Abstract
Depression is a mental disorder characterized by constant sadness, lack of interest in pleasurable activities, and in severe cases, thoughts of suicide. Omega-3 is an essential fatty acid important for human health, and there are three main types of omega-3, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and alpha-linolenic acid (ALA). Omega-3 may play a role in mental health and its deficiency may be associated with increased depression. The objective of this article was to review the literature on the relationship between omega-3 and the prognosis of depression in adults. To this end, the PICO strategy was adopted to prepare the guiding question and the search for articles was carried out in the PubMed and CAPES Journal Portal databases. When choosing articles, the titles, abstracts and, finally, the full texts were read. 575 articles were identified, however, only 4 articles were considered eligible. Studies point to the relationship between omega 3 and depression, highlighting clinical trials that show the modest effect of n-3 polyunsaturated fatty acids, but with questionable clinical significance, and despite omega 3 showing modest effects in reducing depression, the Evidence is limited, requiring more rigorous studies to understand its real effectiveness.
References
Abelha, L. (2014). Depressão, uma questão de saúde pública. Scielo - Brasil. https://doi.org/10.1590/1414-462X201400030001
Appleton, Katherine M., Voyias, Philip D., Sallis, Hannah M., Dawson, S., Ness, Andrew R., Churchill, R., & Perry, R. (2021). Omega-3 fatty acids for depression in adults. Cochrane Database Syst Rev, 11(11), CD004692. https://doi.org/10.1002/14651858.CD004692.pub5
Carnegie, R., Borges M. C., Jones. H. J., Zheng, J., Haycock, P., Evans, J., & Martin, R., M. (2024). Omega-3 fatty acids and major depression: a Mendelian randomization study. Transl Psychiatry, 14(1), 222. https://doi.org/ 10.1038/s41398-024-02932-w
Cholewski, M., Tomczykowa, M., & Tomczyk, M. (2018). A Comprehensive Review of Chemistry, Sources and Bioavailability of Omega-3 Fatty Acids. Nutrientes, 10(11), 1662. https://doi.org/10.3390/nu10111662
Cussotto, S., Delgado, I., Oriolo, G., Kemper, J., Begarie, D., Dexpert, S., Sauvant, J., Leboyer, M., Aouizerate, B., Martin-Santos, R., Schaefer, M., & Capuron, L. (2022). Low omega-3 polyunsaturated fatty acids predict reduced response to standard antidepressants in patients with major depressive disorder. Depress Anxiety, 39(5), 407-418. https://doi.org/ 10.1002/da.23257
Ekinci, G. N., & Sanlier, N. (2023). The relationship between nutrition and depression in the life process: A mini-review. Exp Gerontol, 172, 112072. https://doi.org/10.1016/j.exger.2022.112072
Gelinda Deacon 1, Chaleira Christine 1, David Hayes 2, Cristina Dennis 2, & José Tucci. (2017). Omega 3 polyunsaturated fatty acids and the treatment of depression. Crit Rev Food Sci Nutr, 57(1), 212-223. https://doi.org/10.1080/10408398.2013.876959
Hepsomali, P., & Groeger, J. A. (2021). Diet, Sleep, and Mental Health: Insights from the UK Biobank Study. Nutrientes, 13(8), 2573. https://doi.org/10.3390/nu13082573
Jardim, S. (2011). Depressão e trabalho: ruptura de laço social. Scielo - Brasil. https://doi.org/10.1590/S0303-76572011000100008
Monroe, S. M., & Harkness, K. L. (2022). Major Depression and Its Recurrences: Life Course Matters. Annu Rev Clin Psychol, 9, 18,329-357. https://doi.org/10.1146/annurev-clinpsy-072220-021440
Murphy R. A., Devarshi P. P., Ekimura, S., Marshall, K., & Mitmesser, S. H. (2021). Serum long chain omega-3 fatty acids and depression among adults in the United States: An analysis of NHANES 2011–2012. Science Direct. https://doi.org/10.1016/j.jadr.2021.100089
Opie, R. S., Itsiopoulos, C., Parletta, N., Sanchez-Villegas, A., Akbaraly, T. N., Ruusunen, A., & Jacka, F. N. (2016). Dietary recommendations for the prevention of depression. Nutr Neurosci, 20(3), 161-171. https://doi.org/10.1179/1476830515Y.0000000043
Parletta, N., Zarnowiecki, D., Cho, J., Wilson, A., Bogomolova, S., Villani, A., Itsiopoulos, C., Niyonsenga, T., Blunden, S., Meyer, B., Segal, L., Baune, B. T., & O'Dea, K. (2017). A Mediterranean-style dietary intervention supplemented with fish oil improves diet quality and mental health in people with depression: A randomized controlled trial (HELFIMED). Nutr Neurosci, 22(7), 474-487. https://doi.org/10.1080/1028415X.2017.1411320
Parmentier, M., Mahmoud, C. A. S., Linder, M., & Fanni, J. (2007). Polar lipids: n-3 PUFA carriers for membranes and brain: nutritional interest and emerging processes. OCL - Oilseeds and fats, Crops and Lipids. https://doi.org/10.1051/ocl.2007.0127
Quelaidite, C. F., Gibson, L., & Dyall, S. C. (2023). Effects of long-chain omega-3 polyunsaturated fatty acids on reducing anxiety and/or depression in adults; A systematic review and meta-analysis of randomised controlled trials. Prostaglandins Leukot Essent Fatty Acids, 192, 102572. https://doi.org/10.1016/j.plefa.2023.102572
Shahidi, F & Ambigaipalan, P. (2018). Omega-3 Polyunsaturated Fatty Acids and Their Health Benefits. Annu Rev Food Sci Technol, 9, 345-381. https://doi.org/ 10.1146/annurev-food-111317-095850
Sontrop, J., & Campbell, M. K. (2006). Omega-3 polyunsaturated fatty acids and depression: a review of the evidence and a methodological critique. Prev Med, 42(1), 4-13. https://doi.org/10.1016/j.ypmed.2005.11.005
Souza, M. T., Silva, M. D., & Carvalho, R. (2010). Revisão integrativa: o que é e como fazer. Scielo - Brasil. https://doi.org/10.1590/S1679-45082010RW1134
Subbaiah, P. V., Dammanahalli, K. J., Yang, P., Bi, J., & O’Donnell, J. M. (2016). Enhanced incorporation of dietary DHA into lymph phospholipids by altering its molecular carrier. Biochim Biophis Acta, 1861(8 Pt A), 723-9. https://doi.org/10.1016/j.bbalip.2016.05.002
World Health Organization. (2014). Preventing suicide, a global imperative. https://www.who.int/publications/i/item/9789241564779
Youdim, K. A., Martin A., & Joseph, J. A. (2000). Essential fatty acids and the brain: possible health implications. Int J Dev Neurosci, 18(4-5), 383-99. https://doi.org/10.1016/s0736-5748(00)00013-7
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