Association of demographic and clinical factors with sepsis severity and outcome

Authors

DOI:

https://doi.org/10.33448/rsd-v9i9.7759

Keywords:

Sepsis; Shock septic; Hyperlactatemia; Protocols.

Abstract

Objective: To analyze the association of demographic, clinical factors and lactate levels, with the severity and outcome of sepsis. Method: A cohort study, involving 1184 patients from a university hospital in Porto Alegre / Rio Grande do Sul, Brazil. Data collection took place through active search and medical records of patients with sepsis, from 2013 to 2015. Result: 59.7% (707) came from the emergency, with 2.0 ± 1.39 comorbidities due to with a similar distribution between men and women. Sepsis affected most of the patients, but mostly for septic shock, with respiratory as the main focus. Serum lactate levels (greater than 4 mmol / l) resulted in higher mortality and less than 6% had the lactate recovered until the sixth hour. Conclusion: Demographic and clinical factors that were associated with severity and outcomes were the origin and lactate collection in up to 3 hours. Lactate once again showed that it is an important marker of severity for septic patients, it should not be a marker used only in septic shock, but in cases of suspected sepsis. Sepsis care is of fundamental importance from diagnosis to treatment.

References

Barros, L. L. S., et al. (2016). Fatores de risco associados ao agravamento de sepse em pacientes em Unidade de Terapia Intensiva. Cadernos Saúde Coletiva, 24(4), 388–396.

Casserly, B., et al. (2015) Lactate measurements in sepsis-induced tissue hypoperfusion: results from the Surviving Sepsis Campaing Database. Critical Care Medicine, 43(3),567-573.

Cecconi, M., et al. (2014). Consensus on circulatory shock and hemodynamic monitoring. Task Force of the European Society of Intensive Care Medicine. Intensive Care Med.,40(12),1795-1815.

Cheng, H. H., et al. (2018). Difference between elderly and non-elderly patients in using serum lactate level to predict mortality caused by sepsis in the emergency department. Medicine, 97(13), e0209.

Chertoff, J., Chisum, M., Simmons, L., King, B., Walker, M. & Lascano, J. (2016) Prognostic utility of plasma lactate measured between 24 and 48 h after initiation of early goal-directed therapy in the management of sepsis, severe sepsis, and septic shock. Journal of Intensive Care, 4(13),1-8.

Instituto Latino Americano de Sepse. (2019). Campanha sobrevivendo à sepse: relatório nacional.

Instituto Latino Americano de Sepse. (2018). Implementação de protocolo gerenciado de sepse: protocolo clínico.

Leisman, D., et al. (2016). Association of fluid resuscitation initiation within 30 minutes of severe sepsis and septic shock recognition with reduced mortality and length of stay. Annals of Emergency Medicine.

Liu, Z., Meng, Z., Li, Y., Zhao, J., Wu, S., Gou, S., & Wu, H. (2019). Prognostic accuracy of the serum lactate level, the SOFA score and the qSOFA score for mortality among adults with Sepsis. Scand J Trauma Resusc Emerg Med., 27(1),51.

Lokhandwala, S., Patel, P., Cocchi, M. N. & Donnino, M. W. (2015). Serial absolute lactate value < 4 versus relative10% reduction as a predictor of mortality insevere sepsis and septic shock. Intensive Care Medicine Experimental, 3(1),1-2.

Machado, F., et al. (2017). The epidemiology of sepsis in Brazilian intensive care units (the Sepsis PREvalence Assessment Database, SPREAD): an observational study. The Lancet Infectious Diseases, 17(11), 1180 – 1189.

Moura, J. M., et al. (2017). Diagnóstico de sepse em pacientes após internação em unidade de terapia intensiva. Arquivos de Ciências da Saúde, 24(3), 55-60.

Pereira, A.S., Shitsuka, D.M., Perreira, F.J., & Shitsuka, R. (2018). Metodologia da pesquisa científica.

Rhee, C., et al. (2016). Diagnosing sepsis is subjective and highly variable: a survey of intensivists using case vignettes. Crit Care, 20, 89.

Rhodes, A., et al. (2015). The Surviving Sepsis Campaign bundles and outcome: results from the International Multicentre Prevalence Study on Sepsis (the IMPreSS study). Intensive Care Medicine, 41, 1620–1628.

Rodhes A. et al. (2017). Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock. Critical Care Medicine,. 43, 304-377.

Silva, E. F. G. C., et al. (2020). Nurse's activity in the intensive therapy unit identification of sepse's signs and symptoms. Research, Society and Development, 9(8), e949986094.

Singer, M., et al. (2016) The third international consensus definitions for sepsis and septic shock (sepsis-3). Journal of the American Medical Association, 315(8), 801-810.

Thomas-Rueddel, D. O. et al. (2015). Hyperlactatemia is an independent predictor of mortality and denotes distinct subtypes of severe sepsis and septic shock, Journal of Critical Care, 30(2), 439.e1-439.e6.

Van den Nouland, D. P., Brouwers, M. C., & Stassen, P. M. (2017). Prognostic value of plasma lactate levels in a retrospective cohort presenting at a university hospital emergency department. BMJ Open, 7(1), e011450.

Published

06/09/2020

How to Cite

OLIVEIRA , V. M. de .; LEWIS, M. L. .; MORETTI , M. M. S. .; NASCIMENTO, A. P. do .; LOBO, L. G. .; URBANETTO, J. de S. . Association of demographic and clinical factors with sepsis severity and outcome. Research, Society and Development, [S. l.], v. 9, n. 9, p. e778997759, 2020. DOI: 10.33448/rsd-v9i9.7759. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/7759. Acesso em: 19 apr. 2024.

Issue

Section

Health Sciences