High intensity interval training (HIIT) as a viable alternative to induce the prevention of respiratory diseases: a point of view of exercise immunology during COVID-19 outbreak

Authors

DOI:

https://doi.org/10.33448/rsd-v9i10.9186

Keywords:

Immune Complex; Exercise; Severe acute respiratory syndrome related coronavirus; High-Intensity Intermittent Exercise.

Abstract

The immune system's response against SARS-Cov-2 seems crucial to control viral infection, since this system is homeostatic, dynamic and promotes immunoprotection of the organism through the activation of the innate and adaptive immune system via activation of cellular and chemical complexes that recognize, neutralize, metabolize and eliminate heterologous substances, with or without tissue damage. An obesogenic microenvironment can further increase the risk of disease complications, and cause a more virulent viral strain and a more lethal virus. Moreover, physical inactivity as well as poor eating habits impairs the body's energy metabolism and immune cells due to low-grade chronic inflammation. Studies suggest that light to moderate exercise, as well as mild calorie restriction, as an effective approach to relieve obesity and therefore an interesting strategy to strengthen the immune response during the outbreak of COVID-19, while a vaccine is not developed. Some studies have been shown significant findings in favor of High intensity interval training (HIIT) protocols when compared to moderate intensity exercise, showing how immunological system responds to vigorous to high intensity training. However, HIIT has a lower cost of time, reducing the time/efficiency ratio, that is, a lower cost of time with similar or even better benefits to higher volume exercise programs. Let us not forget: "time is the most precious asset we have".

References

Born, D.-P., Zinner, C., & Sperlich, B. (2017). The Mucosal Immune Function Is Not Compromised during a Period of High-Intensity Interval Training. Is It Time to Reconsider an Old Assumption? Frontiers in Physiology, 8. https://doi.org/10.3389/fphys.2017.00485

Horiguchi, H., Loftus, T. J., Hawkins, R. B., Raymond, S. L., Stortz, J. A., Hollen, M. K., Weiss, B. P., Miller, E. S., Bihorac, A., Larson, S. D., Mohr, A. M., Brakenridge, S. C., Tsujimoto, H., Ueno, H., Moore, F. A., Moldawer, L. L., & Efron, P. A. (2018). Innate Immunity in the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome and Its Implications for Therapy. Frontiers in Immunology, 9. https://doi.org/10.3389/fimmu.2018.00595

James, B. D., Jones, A. v, Trethewey, R. E., & Evans, R. A. (2018). Obesity and metabolic syndrome in COPD: Is exercise the answer? Chronic Respiratory Disease, 15(2), 173–181. https://doi.org/10.1177/1479972317736294

Jin, W., Wang, H., Yan, W., Xu, L., Wang, X., Zhao, X., Yang, X., Chen, G., & Ji, Y. (2008). Disruption of Nrf2 Enhances Upregulation of Nuclear Factor-B Activity, Proinflammatory Cytokines, and Intercellular Adhesion Molecule-1 in the Brain after Traumatic Brain Injury. Mediators of Inflammation, 2008, 1–7. https://doi.org/10.1155/2008/725174

Khammassi, M., Ouerghi, N., Said, M., Feki, M., Khammassi, Y., Pereira, B., Thivel, D., & Bouassida, A. (2020). Continuous Moderate-Intensity but Not High-Intensity Interval Training Improves Immune Function Biomarkers in Healthy Young Men. Journal of Strength and Conditioning Research, 34(1), 249–256. https://doi.org/10.1519/JSC.0000000000002737

Luzi, L., & Radaelli, M. G. (2020). Influenza and obesity: its odd relationship and the lessons for COVID-19 pandemic. Acta Diabetologica, 57(6), 759–764. https://doi.org/10.1007/s00592-020-01522-8

Mao, L., Wang, H., Qiao, L., & Wang, X. (2010). Disruption of Nrf2 Enhances the Upregulation of Nuclear Factor-kappaB Activity, Tumor Necrosis Factor and Matrix Metalloproteinase-9 after Spinal Cord Injury in Mice. Mediators of Inflammation, 2010, 1–10. https://doi.org/10.1155/2010/238321

Netea, M. G., Joosten, L. A. B., Latz, E., Mills, K. H. G., Natoli, G., Stunnenberg, H. G., ONeill, L. A. J., & Xavier, R. J. (2016). Trained immunity: A program of innate immune memory in health and disease. Science, 352(6284), aaf1098–aaf1098. https://doi.org/10.1126/science.aaf1098

Nieman, D. C., Johanssen, L. M., Lee, J. W., & Arabatzis, K. (1990). Infectious episodes in runners before and after the Los Angeles Marathon. J Sports Med Phys Fitness, 30(3), 316–328.

Nieman, David C. (2007). Marathon Training and Immune Function. Sports Medicine, 37(4), 412–415. https://doi.org/10.2165/00007256-200737040-00036

Pedersen, B. K., & Saltin, B. (2015). Exercise as medicine - evidence for prescribing exercise as therapy in 26 different chronic diseases. Scandinavian Journal of Medicine & Science in Sports, 25, 1–72. https://doi.org/10.1111/sms.12581

Shaw, D. M., Merien, F., Braakhuis, A., & Dulson, D. (2018). T-cells and their cytokine production: The anti-inflammatory and immunosuppressive effects of strenuous exercise. Cytokine, 104, 136–142. https://doi.org/10.1016/j.cyto.2017.10.001

Simpson, Campbell, J. P., Gleeson, M., Krüger, K., Nieman, D. C., Pyne, D. B., & Walsh, N. P. (2020). Can exercise affect immune function to increase susceptibility to infection? Exercise Immunology Review, 26, 8–22.

Valencia, D. N. (2020). Brief Review on COVID-19: The 2020 Pandemic Caused by SARS-CoV-2. Cureus. https://doi.org/10.7759/cureus.7386

Wells, A. J., Hoffman, J. R., Jajtner, A. R., Varanoske, A. N., Church, D. D., Gonzalez, A. M., Townsend, J. R., BOONE, C. H., Baker, K. M., Beyer, K. S., Mangine, G. T., Oliveira, L. P., Fukuda, D. H., & Stout, J. R. (2016). Monocyte Recruitment after High-Intensity and High-Volume Resistance Exercise. Medicine & Science in Sports & Exercise, 48(6), 1169–1178. https://doi.org/10.1249/MSS.0000000000000878

Downloads

Published

15/10/2020

How to Cite

PAULA , C. C. de .; MACHADO , S.; COSTA, G. D. C. T. .; SALES, M. M. .; MIRANDA, T. G. .; BARSANULFO, S. R. .; MURILLO-RODRIGUEZ, E.; BUDDE, H.; SÁ FILHO, A. S. . High intensity interval training (HIIT) as a viable alternative to induce the prevention of respiratory diseases: a point of view of exercise immunology during COVID-19 outbreak. Research, Society and Development, [S. l.], v. 9, n. 10, p. e7069109186, 2020. DOI: 10.33448/rsd-v9i10.9186. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/9186. Acesso em: 19 apr. 2024.

Issue

Section

Health Sciences