Activity of glucose-6-phosphate dehydrogenase (G6PD) in newborns in a public hospital in the city of Campina Grande, State of Paraíba, Brazil

Authors

DOI:

https://doi.org/10.33448/rsd-v9i11.9855

Keywords:

Hematology; Glucosphosphate dehydrogenase deficiency; Health of ethnic minorities.

Abstract

In glucose 6 phosphate dehydrogenase (G6PD) deficient erythrocytes, the decrease in the reduction of NADP in NADPH, leads to a low reducing potential that interferes with the oxidative metabolic capacity of the organism, being vulnerable to hemolysis, with oxidation of the globule membrane, which can lead to the hemolytic crisis. The manifestations of G6PD deficiency are triggered by environmental factors such as drugs, beans, infections. Clinical manifestations consist of hemolytic crisis and neonatal jaundice. Studies indicate that in Brazil the prevalence of G6PD is around 1 to 10%, with the highest rates in populations with African ancestry. The objective was to investigate the G6PD deficiency in newborns in a public maternity hospital in the city of Campina Grande. This is a cross-sectional study, where umbilical cord blood was collected from 147 newborns. The diagnosis of G6PD deficiency will be carried out through the methaemoglobin reduction test (Brewer's test). The city of Campina Grande, as well as the entire Borborema Compartment, does not present any data regarding the prevalence of G6PD deficiency. Through the SUS, the Ministry of Health strengthens the collection of information related to this disease with a view to implementing a health care program for detected patients, promoting improvements in their quality of life.

Author Biography

Evaldo Hipólito de Oliveira, Universidade Federal do Piauí

Possui graduação em Farmácia pela Universidade Federal da Paraíba (1990), graduação em Farmácia e Bioquímica pela Universidade Federal da Paraíba (1991), graduação em Direito pela Universidade Federal do Piauí (1999), Doutorado em Biologia de Agentes Infecciosos e Parasitários (2010), mestrado em Administração pela Universidade Federal da Paraíba (2002), especialização em Vigilância Sanitária e Epidemiológica (1997) e Citologia Clínica (2005). Foi Diretor do Laboratório Central de Saúde Pública do Estado do Piauí-LACEN-PI (2003 a 2007). Atualmente é professor Associado da Universidade Federal do Piauí de microbiologia clínica e imunologia clínica (1994). Tem experiência na área de Farmácia (Interdisciplinaridade), atuando principalmente nos seguintes temas: análises clínicas ( bacteriologia, virologia, imunologia, citologia e hematologia ) e Vírus Linfotrópico de Células T Humanas-1/2-HTLV-1/2, HIV, HBV e HCV (Epidemiologa, Imunologia e Análise Molecular).

References

Azevêdo, E. S., & Azevedo, T. F. S. (1974). Glucose-6-phosphate dehydrogenasedeficiencyand neonatal jaundice in Bahia, Brazil. Ciência e Cultura; 26, 044-7.

Batista, D. C., Fernandes, T. A., Maia, U. M. & Pereira, W. O. (2010). Prevalência da deficiência da glicose-6-fosfato desidrogenase em doadores de sangue de Mossoró, Rio Grande do Norte. Rev Bras Hematol Hemoter. 32(5): 422-423.

Brewer, G. J., Tarlov, A. R., Alving, A. S. (1962). The methemoglobin reduction test for primaquine-type sensitivy of erythrocytes: a simplified procedure for detecting a specific hypersuscetibility to drug hemolysis. JAMA. 180, 386-388.

Compri, M. B., et al. (2000). Investigação genético-epidemiológica e molecular da deficiência de G-6-PD em uma comunidade brasileira. Cad. Saúde Pública, Rio de Janeiro, 16(2), June.

Garlipp, C. R., Ramalho, A. S. (1988). Aspectos clínicos e laboratoriais da deficiência de desidrogenase de 6-fosfato de glicose (G-6-PD) em recém-nascidos brasileiros. Rev. Brasil. Genet. 11, 717-28.

Kotaka, M., Gover, S., Vandeputte-Rutten, L., Au, S. W., Lam, V. M. & Adams, M. J. (2005). Structural studies of glucose-6-phosphate and NADP binding to human glucose-6-phosphate dehydrogenase. Acta Crystallogr D Biol Crystallogr; 61, 495-504.

Lewgoy, F., & Salzano, F. M. (1965). Dinâmica do gen que condiciona a deficiência em G-6-PD na população de Porto Alegre. Ciência e Cultura, (2), 152, 1965.

Lima, A. O., et al. (2001). Métodos de laboratório aplicados à clínica: Técnicas e Interpretação. (8a ed.), Rio de Janeiro: Guanabara Koogan. Rio de Janeiro.

Lin, Z., Fontaine, J. M., Freer, D. E. & Naylor, E. W. (2005). Alternative DNA-based newborn screening for glucose-6-phosphate dehydrogenase deficiency. Mol Genet Metab.; 86, 1-2:212-9.

Luzzatto, L., Metha, A. & Vulliamy, T. (2001). Glucose -6-phosphate dehydrogenase deficiency. In: Scriver CR, Baudet AL, Sly WS, Valle D, Childs B, Kinzler KW, Vogelstein B. The metabolic and molecular basis of inherited disease. (8a ed.), McGram-Hill Medical Publishing Division; III, 4517-53.

Nascimento, M. do S. V. do, Oliveira, E. H. de., Nogueira Júnior, F. de A., Albuquerque, V. L. M. de., Soares, C. V. D., Tenório, M. D. F. de C., Lima, E. M., & Soares, L. F. (2020). Hemoglobina variante na comunidade quilombola caiana dos crioulos no Estado da Paraíba, Brasil. Research, Society and Development, 9(11), e3239119892. https://doi.org/10.33448/rsd-v9i11.9892

Ramalho, A. S. & Beiguelman, B. (1976). Deficiência de desidrogenase de 6-fosfato de glicose (G-6-PD) em doadores de sangue brasileiros. F. Méd., 73(3), 281-283.

Ramalho, A. S. (1980). Deficiência de desidrogenase de 6-fosfato de glicose (G-6-PD) em recém-nascidos brasileiros. F. Méd., 81(6), 603-606.

Saldanha, P. H., Nóbrega, F. C. & Maia, J. C. C. (1969). Distribution and here dityoferythrocyte G-6-PD activity and electrophoretic variants among different racial group sat São Paulo, Brazil. J. Med. Genet. 6, 48-54.

Downloads

Published

28/11/2020

How to Cite

SILVA, K. M. da C. e .; OLIVEIRA, E. H. de .; FERNANDES, S. S. .; LINS, S. P. .; NÓBREGA, R. de A. .; MOREIRA, V. M. .; NOGUEIRA JÚNIOR, F. A. .; NASCIMENTO, M. do S. V. do .; SOARES, L. F. . Activity of glucose-6-phosphate dehydrogenase (G6PD) in newborns in a public hospital in the city of Campina Grande, State of Paraíba, Brazil. Research, Society and Development, [S. l.], v. 9, n. 11, p. e6399119855, 2020. DOI: 10.33448/rsd-v9i11.9855. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/9855. Acesso em: 26 dec. 2024.

Issue

Vol. 9 No. 11

Section

Health Sciences

License

Copyright (c) 2020 Keylla Malba da Costa e Silva; Evaldo Hipólito de Oliveira; Suenia Soares Fernandes; Sarah Pereira Lins; Raquel de Almeida Nóbrega; Vandiara Martins Moreira; Francisco Assis Nogueira Júnior; Maria do Socorro Viana do Nascimento; Leonardo Ferreira Soares

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.