Routine laboratory parameters of newly diagnosed pulmonary tuberculosis patients: a single center study in Brazil
Keywords:Diagnostic imaging; Water-electrolyte imbalance; Mycobacterium tuberculosis; Neutrophil; Signs and symptoms.
Objective: Evaluate the severity of tuberculosis and its association with laboratory tests before antituberculosis treatment. Methodology: Patients with pulmonary tuberculosis were evaluated for severity using data available in medical records (Clinical; Excretion of mycobacteria; and Diagnostic imaging) and associated with biochemical and hematological parameters requested at the time of diagnosis and before antituberculosis treatment. Results: The evaluation of the severity showed a predominance of smear AFB (+), fever associated with other symptoms and infiltrative tuberculosis. Only a positive correlation between mycobacteria excretion and imaging diagnosis (rho=0.47; p=0.023) was observed. The patients presented hyponatremia (9/21), hypomagnesemia (6/13), and hypercalcemia (1/13), unrelated to the severity. The presence of fever influenced the number of non-segmented neutrophils (p=0.0142) and the total leukocyte count correlated with the increase in total neutrophils (rho=0.9631; p<0.0001). Conclusion: Different severity characteristics of tuberculosis, although they reflect the degree of commitment of the patient, are not always correlated; the evaluation of electrolytes could contribute to clinical behavior; and non-segmented neutrophils are associated with a worse clinical prognosis in patients with tuberculosis.
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Copyright (c) 2020 Ana Paula Biadola; André Aparecido dos Santos Correa; Amanda Aparecida Silva de Aguiar; Ualter Guilherme Cipriano Rosa; Paulo José Mascarenhas Mazaro; Christiane Martinez Húngaro; Marcus Vinícius Pimenta Rodrigues; Eliana Peresi-Lordelo
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