Routine laboratory parameters of newly diagnosed pulmonary tuberculosis patients: a single center study in Brazil
DOI:
https://doi.org/10.33448/rsd-v9i11.9873Keywords:
Diagnostic imaging; Water-electrolyte imbalance; Mycobacterium tuberculosis; Neutrophil; Signs and symptoms.Abstract
Objective: Evaluate the severity of tuberculosis and its association with laboratory tests before antituberculosis treatment. Methodology: Patients with pulmonary tuberculosis were evaluated for severity using data available in medical records (Clinical; Excretion of mycobacteria; and Diagnostic imaging) and associated with biochemical and hematological parameters requested at the time of diagnosis and before antituberculosis treatment. Results: The evaluation of the severity showed a predominance of smear AFB (+), fever associated with other symptoms and infiltrative tuberculosis. Only a positive correlation between mycobacteria excretion and imaging diagnosis (rho=0.47; p=0.023) was observed. The patients presented hyponatremia (9/21), hypomagnesemia (6/13), and hypercalcemia (1/13), unrelated to the severity. The presence of fever influenced the number of non-segmented neutrophils (p=0.0142) and the total leukocyte count correlated with the increase in total neutrophils (rho=0.9631; p<0.0001). Conclusion: Different severity characteristics of tuberculosis, although they reflect the degree of commitment of the patient, are not always correlated; the evaluation of electrolytes could contribute to clinical behavior; and non-segmented neutrophils are associated with a worse clinical prognosis in patients with tuberculosis.
References
Agrawal, Y., Goyal, V., Singh, A., & Lal, S. (2017). Role of Anaemia and Magnesium Levels at the Initiation of Tuberculosis Therapy with Sputum Conversion among Pulmonary Tuberculosis Patients. Journal of clinical and diagnostic research : JCDR, 11(6), BC01–BC04. https://doi.org/10.7860/JCDR/2017/23734.9975
AL-Omar, I. A., Al-Ashban, R. M. & Shah, A. H. (2009). Hematological abnormalities in saudis suffering from pulmonary tuberculosis and their response to the treatment, Research Journal of Pharmacology, 3(4), 78-85.
Badar, A., Arif, Z., & Alam, K. (2018). Role of Carbamylated Biomolecules in Human Diseases. IUBMB life, 70(4), 267–275. https://doi.org/10.1002/iub.1732
Banfi, G., & Del Fabbro, M. (2006). Serum creatinine values in elite athletes competing in 8 different sports: comparison with sedentary people. Clinical chemistry, 52(2), 330–331. https://doi.org/10.1373/clinchem.2005.061390
Basseto, T. P., Azzalis, L. A., Pereira, E. C., Junqueira, V. B. C., Caputo, L. Z., Fonseca, A. L. A., Feder, D. & Fonseca, F. L. A.. (2013). Comparison between two methods of ionized calcium measurement in newborns. Jornal Brasileiro de Patologia e Medicina Laboratorial, 49(5), 317-319. https://dx.doi.org/10.1590/S1676-24442013000500003
Bertolozzi, M. R., Takahashi, R. F., Hino, P., Litvoc, M. & França, F. (2014). “Tuberculosis’ control: a challenge for the public health,” Revista de Medicina, 93(2), 83–9. https://doi.org/10.11606/issn.1679-9836.v93i2p83-89
Chandra, T & Sowjanya, M . (2018). Correlation between serum Calcium levels and smear grading among the pulmonary tuberculosis patients . Journal of Microbiology and Infectious Diseases , 8 (01) , 19-22 . DOI: 10.5799/jmid.396290
Edmund, L. & David, J. (2006) Kidney function tests. In: Carl AB, Edward R, David E, editors. Tietz Textbook of clinical chemistry and molecular diagnostics 4th ed. New Delhi: Elsevier Inc.
Giacomelli, I. L., Neto, R. S., Nin, C. S., Cassano, P. S., Pereira, M., Moreira, J. S., Nascimento, D. Z. & Hochhegger, B. (2017). High-resolution computed tomography findings of pulmonary tuberculosis in lung transplant recipients, Jornal Brasileiro de Pneumologia, 43(4), 270–3,. http://dx.doi.org/10.1590/s1806-37562016000000306
Irfan, D., Rafi, D.M., Verma, D.B., & DrDeepu, C. (2017). The inverse correlation of serum Magnesium level with the stage of Pulmonary Tuberculosis. Scholars Journal of Applied Medical Sciences, 5(3F), 1131-1136. https://doi.org/10.21276/sjams.2017.5.3.79
Jonaidi Jafari, N., Izadi, M., Sarrafzadeh, F., Heidari, A., Ranjbar, R., & Saburi, A. (2013). Hyponatremia due to pulmonary tuberculosis: review of 200 cases. Nephro-urology monthly, 5(1), 687–691. https://doi.org/10.5812/numonthly.7091
Kardalas, E., Paschou, S. A., Anagnostis, P., Muscogiuri, G., Siasos, G., & Vryonidou, A. (2018). Hypokalemia: a clinical update. Endocrine connections, 7(4), R135–R146. https://doi.org/10.1530/EC-18-0109
Kassa, E., Enawgaw, B., Gelaw, A., & Gelaw, B. (2016). Effect of anti-tuberculosis drugs on hematological profiles of tuberculosis patients attending at University of Gondar Hospital, Northwest Ethiopia. BMC hematology, 16, 1. https://doi.org/10.1186/s12878-015-0037-1
Korzelius, C., Schrier, R. W., Sterns, R. H., & Thompson, C. J. (2013). Diagnosis, evaluation, and treatment of hyponatremia: expert panel recommendations. The American journal of medicine, 126(10 Suppl 1), S1–S42. https://doi.org/10.1016/j.amjmed.2013.07.006
Lowe, D. M., Bandara, A. K., Packe, G. E., Barker, R. D., Wilkinson, R. J., Griffiths, C. J., & Martineau, A. R. (2013). Neutrophilia independently predicts death in tuberculosis. The European respiratory journal, 42(6), 1752–1757. https://doi.org/10.1183/09031936.00140913
Lowe, D. M., Redford, P. S., Wilkinson, R. J., O'Garra, A., & Martineau, A. R. (2012). Neutrophils in tuberculosis: friend or foe?. Trends in immunology, 33(1), 14–25. https://doi.org/10.1016/j.it.2011.10.003
Lyadova I. V. (2017). Neutrophils in Tuberculosis: Heterogeneity Shapes the Way?. Mediators of inflammation, 2017, 8619307. https://doi.org/10.1155/2017/8619307
Memon, Z., Shah, A.M., & Kazi, T. (2014). Study of calcium in active pulmonary tuberculosis patients by flame atomic absorption spectrophotometer. Indo American Journal of Pharmaceutical Research, 4, 5394-5398.
Mohamed-Hussein, A. R., Salama, S., Khalil, M. & Eid, S. (2016). Malnutrition in tuberculosis: value of fat-free mass and creatinine-height index, Egyptian Journal of Bronchology, 10(1), 58-63. http://dx.doi.org/10.4103/1687-8426.176790
Morris, C. D., Bird, A. R., & Nell, H. (1989). The haematological and biochemical changes in severe pulmonary tuberculosis. The Quarterly journal of medicine, 73(272), 1151–1159.
Murthy, S. E., Chatterjee, F., Crook, A., Dawson, R., Mendel, C., Murphy, M. E., Murray, S. R., Nunn, A. J., Phillips, P., Singh, K. P., McHugh, T. D., Gillespie, S. H., & REMoxTB Consortium (2018). Pretreatment chest x-ray severity and its relation to bacterial burden in smear positive pulmonary tuberculosis. BMC medicine, 16(1), 73. https://doi.org/10.1186/s12916-018-1053-3
Olalekan, A. W., Oluwaseun, F. A., Oladele, H. A. & Akeem, A. D. (2015). Evaluation of electrolyte imbalance among tuberculosis patients receiving treatments in Southwestern Nigeria, Alexandria Journal of Medicine, 51(3), 255-60. https://doi.org/10.1016/j.ajme.2014.10.003
Panteleev, A. V., Nikitina, I. Y., Burmistrova, I. A., Kosmiadi, G. A., Radaeva, T. V., Amansahedov, R. B., Sadikov, P. V., Serdyuk, Y. V., Larionova, E. E., Bagdasarian, T. R., Chernousova, L. N., Ganusov, V. V. & Lyadova, I. V. (2017). Severe tuberculosis in humans correlates best with neutrophil abundance and lymphocyte deficiency and does not correlate with antigen-specific CD4 T-cell response, Frontiers in Immunology, 8, 1-16. http://dx.doi.org/10.3389/fimmu.2017.00963. PMID: 28871253; PMCID: PMC5566990.
Patil, L. & Mrudula, N. (2019). Effect of antitubercular treatment on serum electrolyte and bicarbonate among pulmonary tuberculosis patients in tertiary care Hospital: An observational study, International Journal of Clinical Biochemistry and Research, 6(1), 41-4. https://doi.org/10.18231/2394-6377.2019.0011
Pham, P. C., Pham, P. A., Pham, S. V., Pham, P. T., Pham, P. M., & Pham, P. T. (2014). Hypomagnesemia: a clinical perspective. International journal of nephrology and renovascular disease, 7, 219–230. https://doi.org/10.2147/IJNRD.S42054
Purohit, G., Vernekar, S., Choudhary, C. R., Vyas, S. & Shameel Ahammed, K. K. (2017). Evaluation and comparison of serum electrolytes imbalance among patients with pulmonary tuberculosis, HIV, HIV co-infected with pulmonary tuberculosis & controls, International Journal of Scientific Research, 6(5), 46-8. https://www.doi.org/10.36106/ijsr
Rohini, K., Bhat, S., Srikumar, P. S., & Mahesh Kumar, A. (2014). Assessment of serum calcium and phosphorus in pulmonary tuberculosis patients before, during and after chemotherapy. Indian journal of clinical biochemistry: IJCB, 29(3), 377–381. https://doi.org/10.1007/s12291-013-0383-3
Roussos, A., Lagogianni, I., Gonis, A., Ilias, I., Kazi, D., Patsopoulos, D., & Philippou, N. (2001). Hypercalcaemia in Greek patients with tuberculosis before the initiation of anti-tuberculosis treatment. Respiratory medicine, 95(3), 187–190. https://doi.org/10.1053/rmed.2000.1019
Santos-Mateus, D., Passero, F., Rodrigues, A., Bolas, A., Silva-Pedrosa, R., Pereira, M., Dalastra Laurenti, M. & Santos-Gomes, G. (2016). The Battle between Leishmania and the Host Immune System at a Glance. International Trends in Immunity. 4. 28. 10.18281/iti.2016.1.3.
World Health Organization (WHO) (2019). Global Health TB Report. Retrieved from: https://www.who.int/tb/publications/global_report/en/.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2020 Ana Paula Biadola; André Aparecido dos Santos Correa; Amanda Aparecida Silva de Aguiar; Ualter Guilherme Cipriano Rosa; Paulo José Mascarenhas Mazaro; Christiane Martinez Húngaro; Marcus Vinícius Pimenta Rodrigues; Eliana Peresi-Lordelo
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
