Routine laboratory parameters of newly diagnosed pulmonary tuberculosis patients: a single center study in Brazil

Authors

DOI:

https://doi.org/10.33448/rsd-v9i11.9873

Keywords:

Diagnostic imaging; Water-electrolyte imbalance; Mycobacterium tuberculosis; Neutrophil; Signs and symptoms.

Abstract

Objective: Evaluate the severity of tuberculosis and its association with laboratory tests before antituberculosis treatment. Methodology: Patients with pulmonary tuberculosis were evaluated for severity using data available in medical records (Clinical; Excretion of mycobacteria; and Diagnostic imaging) and associated with biochemical and hematological parameters requested at the time of diagnosis and before antituberculosis treatment. Results: The evaluation of the severity showed a predominance of smear AFB (+), fever associated with other symptoms and infiltrative tuberculosis. Only a positive correlation between mycobacteria excretion and imaging diagnosis (rho=0.47; p=0.023) was observed. The patients presented hyponatremia (9/21), hypomagnesemia (6/13), and hypercalcemia (1/13), unrelated to the severity. The presence of fever influenced the number of non-segmented neutrophils (p=0.0142) and the total leukocyte count correlated with the increase in total neutrophils (rho=0.9631; p<0.0001). Conclusion: Different severity characteristics of tuberculosis, although they reflect the degree of commitment of the patient, are not always correlated; the evaluation of electrolytes could contribute to clinical behavior; and non-segmented neutrophils are associated with a worse clinical prognosis in patients with tuberculosis.

References

Agrawal, Y., Goyal, V., Singh, A., & Lal, S. (2017). Role of Anaemia and Magnesium Levels at the Initiation of Tuberculosis Therapy with Sputum Conversion among Pulmonary Tuberculosis Patients. Journal of clinical and diagnostic research : JCDR, 11(6), BC01–BC04. https://doi.org/10.7860/JCDR/2017/23734.9975

AL-Omar, I. A., Al-Ashban, R. M. & Shah, A. H. (2009). Hematological abnormalities in saudis suffering from pulmonary tuberculosis and their response to the treatment, Research Journal of Pharmacology, 3(4), 78-85.

Badar, A., Arif, Z., & Alam, K. (2018). Role of Carbamylated Biomolecules in Human Diseases. IUBMB life, 70(4), 267–275. https://doi.org/10.1002/iub.1732

Banfi, G., & Del Fabbro, M. (2006). Serum creatinine values in elite athletes competing in 8 different sports: comparison with sedentary people. Clinical chemistry, 52(2), 330–331. https://doi.org/10.1373/clinchem.2005.061390

Basseto, T. P., Azzalis, L. A., Pereira, E. C., Junqueira, V. B. C., Caputo, L. Z., Fonseca, A. L. A., Feder, D. & Fonseca, F. L. A.. (2013). Comparison between two methods of ionized calcium measurement in newborns. Jornal Brasileiro de Patologia e Medicina Laboratorial, 49(5), 317-319. https://dx.doi.org/10.1590/S1676-24442013000500003

Bertolozzi, M. R., Takahashi, R. F., Hino, P., Litvoc, M. & França, F. (2014). “Tuberculosis’ control: a challenge for the public health,” Revista de Medicina, 93(2), 83–9. https://doi.org/10.11606/issn.1679-9836.v93i2p83-89

Chandra, T & Sowjanya, M . (2018). Correlation between serum Calcium levels and smear grading among the pulmonary tuberculosis patients . Journal of Microbiology and Infectious Diseases , 8 (01) , 19-22 . DOI: 10.5799/jmid.396290

Edmund, L. & David, J. (2006) Kidney function tests. In: Carl AB, Edward R, David E, editors. Tietz Textbook of clinical chemistry and molecular diagnostics 4th ed. New Delhi: Elsevier Inc.

Giacomelli, I. L., Neto, R. S., Nin, C. S., Cassano, P. S., Pereira, M., Moreira, J. S., Nascimento, D. Z. & Hochhegger, B. (2017). High-resolution computed tomography findings of pulmonary tuberculosis in lung transplant recipients, Jornal Brasileiro de Pneumologia, 43(4), 270–3,. http://dx.doi.org/10.1590/s1806-37562016000000306

Irfan, D., Rafi, D.M., Verma, D.B., & DrDeepu, C. (2017). The inverse correlation of serum Magnesium level with the stage of Pulmonary Tuberculosis. Scholars Journal of Applied Medical Sciences, 5(3F), 1131-1136. https://doi.org/10.21276/sjams.2017.5.3.79

Jonaidi Jafari, N., Izadi, M., Sarrafzadeh, F., Heidari, A., Ranjbar, R., & Saburi, A. (2013). Hyponatremia due to pulmonary tuberculosis: review of 200 cases. Nephro-urology monthly, 5(1), 687–691. https://doi.org/10.5812/numonthly.7091

Kardalas, E., Paschou, S. A., Anagnostis, P., Muscogiuri, G., Siasos, G., & Vryonidou, A. (2018). Hypokalemia: a clinical update. Endocrine connections, 7(4), R135–R146. https://doi.org/10.1530/EC-18-0109

Kassa, E., Enawgaw, B., Gelaw, A., & Gelaw, B. (2016). Effect of anti-tuberculosis drugs on hematological profiles of tuberculosis patients attending at University of Gondar Hospital, Northwest Ethiopia. BMC hematology, 16, 1. https://doi.org/10.1186/s12878-015-0037-1

Korzelius, C., Schrier, R. W., Sterns, R. H., & Thompson, C. J. (2013). Diagnosis, evaluation, and treatment of hyponatremia: expert panel recommendations. The American journal of medicine, 126(10 Suppl 1), S1–S42. https://doi.org/10.1016/j.amjmed.2013.07.006

Lowe, D. M., Bandara, A. K., Packe, G. E., Barker, R. D., Wilkinson, R. J., Griffiths, C. J., & Martineau, A. R. (2013). Neutrophilia independently predicts death in tuberculosis. The European respiratory journal, 42(6), 1752–1757. https://doi.org/10.1183/09031936.00140913

Lowe, D. M., Redford, P. S., Wilkinson, R. J., O'Garra, A., & Martineau, A. R. (2012). Neutrophils in tuberculosis: friend or foe?. Trends in immunology, 33(1), 14–25. https://doi.org/10.1016/j.it.2011.10.003

Lyadova I. V. (2017). Neutrophils in Tuberculosis: Heterogeneity Shapes the Way?. Mediators of inflammation, 2017, 8619307. https://doi.org/10.1155/2017/8619307

Memon, Z., Shah, A.M., & Kazi, T. (2014). Study of calcium in active pulmonary tuberculosis patients by flame atomic absorption spectrophotometer. Indo American Journal of Pharmaceutical Research, 4, 5394-5398.

Mohamed-Hussein, A. R., Salama, S., Khalil, M. & Eid, S. (2016). Malnutrition in tuberculosis: value of fat-free mass and creatinine-height index, Egyptian Journal of Bronchology, 10(1), 58-63. http://dx.doi.org/10.4103/1687-8426.176790

Morris, C. D., Bird, A. R., & Nell, H. (1989). The haematological and biochemical changes in severe pulmonary tuberculosis. The Quarterly journal of medicine, 73(272), 1151–1159.

Murthy, S. E., Chatterjee, F., Crook, A., Dawson, R., Mendel, C., Murphy, M. E., Murray, S. R., Nunn, A. J., Phillips, P., Singh, K. P., McHugh, T. D., Gillespie, S. H., & REMoxTB Consortium (2018). Pretreatment chest x-ray severity and its relation to bacterial burden in smear positive pulmonary tuberculosis. BMC medicine, 16(1), 73. https://doi.org/10.1186/s12916-018-1053-3

Olalekan, A. W., Oluwaseun, F. A., Oladele, H. A. & Akeem, A. D. (2015). Evaluation of electrolyte imbalance among tuberculosis patients receiving treatments in Southwestern Nigeria, Alexandria Journal of Medicine, 51(3), 255-60. https://doi.org/10.1016/j.ajme.2014.10.003

Panteleev, A. V., Nikitina, I. Y., Burmistrova, I. A., Kosmiadi, G. A., Radaeva, T. V., Amansahedov, R. B., Sadikov, P. V., Serdyuk, Y. V., Larionova, E. E., Bagdasarian, T. R., Chernousova, L. N., Ganusov, V. V. & Lyadova, I. V. (2017). Severe tuberculosis in humans correlates best with neutrophil abundance and lymphocyte deficiency and does not correlate with antigen-specific CD4 T-cell response, Frontiers in Immunology, 8, 1-16. http://dx.doi.org/10.3389/fimmu.2017.00963. PMID: 28871253; PMCID: PMC5566990.

Patil, L. & Mrudula, N. (2019). Effect of antitubercular treatment on serum electrolyte and bicarbonate among pulmonary tuberculosis patients in tertiary care Hospital: An observational study, International Journal of Clinical Biochemistry and Research, 6(1), 41-4. https://doi.org/10.18231/2394-6377.2019.0011

Pham, P. C., Pham, P. A., Pham, S. V., Pham, P. T., Pham, P. M., & Pham, P. T. (2014). Hypomagnesemia: a clinical perspective. International journal of nephrology and renovascular disease, 7, 219–230. https://doi.org/10.2147/IJNRD.S42054

Purohit, G., Vernekar, S., Choudhary, C. R., Vyas, S. & Shameel Ahammed, K. K. (2017). Evaluation and comparison of serum electrolytes imbalance among patients with pulmonary tuberculosis, HIV, HIV co-infected with pulmonary tuberculosis & controls, International Journal of Scientific Research, 6(5), 46-8. https://www.doi.org/10.36106/ijsr

Rohini, K., Bhat, S., Srikumar, P. S., & Mahesh Kumar, A. (2014). Assessment of serum calcium and phosphorus in pulmonary tuberculosis patients before, during and after chemotherapy. Indian journal of clinical biochemistry: IJCB, 29(3), 377–381. https://doi.org/10.1007/s12291-013-0383-3

Roussos, A., Lagogianni, I., Gonis, A., Ilias, I., Kazi, D., Patsopoulos, D., & Philippou, N. (2001). Hypercalcaemia in Greek patients with tuberculosis before the initiation of anti-tuberculosis treatment. Respiratory medicine, 95(3), 187–190. https://doi.org/10.1053/rmed.2000.1019

Santos-Mateus, D., Passero, F., Rodrigues, A., Bolas, A., Silva-Pedrosa, R., Pereira, M., Dalastra Laurenti, M. & Santos-Gomes, G. (2016). The Battle between Leishmania and the Host Immune System at a Glance. International Trends in Immunity. 4. 28. 10.18281/iti.2016.1.3.

World Health Organization (WHO) (2019). Global Health TB Report. Retrieved from: https://www.who.int/tb/publications/global_report/en/.

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Published

12/11/2020

How to Cite

Biadola, A. P. ., Correa, A. A. dos S. ., Aguiar, A. A. S. de ., Rosa, U. G. C. ., Mazaro, P. J. M. ., Húngaro, C. M. ., Rodrigues, M. V. P. ., & Peresi-Lordelo, E. (2020). Routine laboratory parameters of newly diagnosed pulmonary tuberculosis patients: a single center study in Brazil. Research, Society and Development, 9(11), e2559119873. https://doi.org/10.33448/rsd-v9i11.9873

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Health Sciences