Neonatal outcomes of pregnant women diagnosed with SARS-CoV-2: an integrative review

Authors

DOI:

https://doi.org/10.33448/rsd-v10i1.10905

Keywords:

Covid-19; SARS-CoV-2; Pregnant; Neonatal results.

Abstract

The present study analyzed the neonatal outcomes reported in pregnant women with COVID-19. An integrative review was carried out after formulating the guiding question. That done, the research strategy, selection of criteria and data extraction were carried out. The searches were performed in the databases "PubMed", "Web of Science", "LILACS" and "ScienceDirect" using the following search terms: 2019-nCoV, covid-19, SARS-CoV-2, pregnant, pregnancy, birth, fetal, neonatal, outcomes, complications and adverse. The studies involved 226 pregnant women diagnosed with COVID-19 and 174 healthy pregnant women. Among the 226 pregnant women with COVID-19, there was 01 intrauterine fetal death and 16 remained pregnant until the end of the respective studies. Thus, 209 pregnant women with COVID-19 evolved for childbirth, resulting in 212 live births. Of these, 127 (59.9%) were born by cesarean delivery, 38 (17.9%) were born at <37 weeks of gestational age [3 (1.4%) <28 weeks] and 16 (7.5) were born at weight <2500 g. Neonatal results included 8 (3.8%) with a positive SARS-CoV-2 test, 12 (5.7%) with fetal distress, neonatal asphyxia, vomiting or skin rashes, 2 (0.9%) with intravascular coagulation disseminated, 1 (0.5%) alteration of cardiac enzymes, 1 (0.5%) multiple organ failure and 1 (0.5%) neonatal death. Various complications have been identified in pregnant women with COVID-19, therefore, a greater care must be given to this population group due to a greater risk of neonatal complications.

References

Bairey Merz, C. N., Pepine, C. J., Shimokawa, H., & Berry, C. (2020). Treatment of coronary microvascular dysfunction. Cardiovascular research, 116(4), 856–870. https://doi.org/10.1093/cvr/cvaa006

Bansal M. (2020). Cardiovascular disease and COVID-19. Diabetes & metabolic syndrome, 14(3), 247–250. https://doi.org/10.1016/j.dsx.2020.03.013

Baloch, S., Baloch, M. A., Zheng, T., & Pei, X. (2020). The Coronavirus Disease 2019 (COVID-19) Pandemic. The Tohoku journal of experimental medicine, 250(4), 271–278. https://doi.org/10.1620/tjem.250.271

Cardoso-Demartini, A., Bagatin, A. C., Silva, R. P., & Boguszewski, M. C. (2011). Crescimento de crianças nascidas prematuras [Growth of preterm-born children]. Arquivos brasileiros de endocrinologia e metabologia, 55(8), 534–540. https://doi.org/10.1590/s0004-27302011000800006

Chen, H., Guo, J., Wang, C., Luo, F., Yu, X., Zhang, W., Li, J., Zhao, D., Xu, D., Gong, Q., Liao, J., Yang, H., Hou, W., & Zhang, Y. (2020). Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet (London, England), 395(10226), 809–815. https://doi.org/10.1016/S0140-6736(20)30360-3

Du, Y., Tu, L., Zhu, P., Mu, M., Wang, R., Yang, P., Wang, X., Hu, C., Ping, R., Hu, P., Li, T., Cao, F., Chang, C., Hu, Q., Jin, Y., & Xu, G. (2020). Clinical Features of 85 Fatal Cases of COVID-19 from Wuhan. A Retrospective Observational Study. American journal of respiratory and critical care medicine, 201(11), 1372–1379. https://doi.org/10.1164/rccm.202003-0543OC

Ferrazzi, E., Frigerio, L., Savasi, V., Vergani, P., Prefumo, F., Barresi, S., Bianchi, S., Ciriello, E., Facchinetti, F., Gervasi, M. T., Iurlaro, E., Kustermann, A., Mangili, G., Mosca, F., Patanè, L., Spazzini, D., Spinillo, A., Trojano, G., Vignali, M., Villa, A., … Cetin, I. (2020). Vaginal delivery in SARS-CoV-2-infected pregnant women in Northern Italy: a retrospective analysis. BJOG : an international journal of obstetrics and gynaecology, 127(9), 1116–1121. https://doi.org/10.1111/1471-0528.16278

Guedes, B. L. C. dos S., Nascimento, A. K. P. do, Melo, B. T. G., Cunha, S. M. D. da, Oliveira Filho, A. A. de, & Oliveira, H. M. B. F. de. (2020). General aspects of COVID-19 in pregnant and newborn health: A brief review. Research, Society and Development, 9(7), e897974969. https://doi.org/10.33448/rsd-v9i7.4969

Guzik, T. J., Mohiddin, S. A., Dimarco, A., Patel, V., Savvatis, K., Marelli-Berg, F. M., Madhur, M. S., Tomaszewski, M., Maffia, P., D'Acquisto, F., Nicklin, S. A., Marian, A. J., Nosalski, R., Murray, E. C., Guzik, B., Berry, C., Touyz, R. M., Kreutz, R., Wang, D. W., Bhella, D., … McInnes, I. B. (2020). COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options. Cardiovascular research, 116(10), 1666–1687. https://doi.org/10.1093/cvr/cvaa106

Henry, B. M., de Oliveira, M., Benoit, S., Plebani, M., & Lippi, G. (2020). Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis. Clinical chemistry and laboratory medicine, 58(7), 1021–1028. https://doi.org/10.1515/cclm-2020-0369

Hu, X., Gao, J., Luo, X., Feng, L., Liu, W., Chen, J., Benachi, A., De Luca, D., & Chen, L. (2020). Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vertical Transmission in Neonates Born to Mothers With Coronavirus Disease 2019 (COVID-19) Pneumonia. Obstetrics and gynecology, 136(1), 65–67. https://doi.org/10.1097/AOG.0000000000003926

Leung, M. P., Thompson, B., Black, J., Dai, S., & Alsweiler, J. M. (2018). The effects of preterm birth on visual development. Clinical & experimental optometry, 101(1), 4–12. https://doi.org/10.1111/cxo.12578

Li, N., Han, L., Peng, M., Lv, Y., Ouyang, Y., Liu, K., Yue, L., Li, Q., Sun, G., Chen, L., & Yang, L. (2020). Maternal and Neonatal Outcomes of Pregnant Women With Coronavirus Disease 2019 (COVID-19) Pneumonia: A Case-Control Study. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 71(16), 2035–2041. https://doi.org/10.1093/cid/ciaa352

Liao, J., He, X., Gong, Q., Yang, L., Zhou, C., & Li, J. (2020). Analysis of vaginal delivery outcomes among pregnant women in Wuhan, China during the COVID-19 pandemic. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 150(1), 53–57. https://doi.org/10.1002/ijgo.13188

Liu, D., Li, L., Wu, X., Zheng, D., Wang, J., Yang, L., & Zheng, C. (2020). Pregnancy and Perinatal Outcomes of Women With Coronavirus Disease (COVID-19) Pneumonia: A Preliminary Analysis. AJR. American journal of roentgenology, 215(1), 127–132. https://doi.org/10.2214/AJR.20.23072

Liu, W., Wang, J., Li, W., Zhou, Z., Liu, S., & Rong, Z. (2020). Clinical characteristics of 19 neonates born to mothers with COVID-19. Frontiers of medicine, 14(2), 193–198. https://doi.org/10.1007/s11684-020-0772-y

Lippi, G., & Plebani, M. (2020). Laboratory abnormalities in patients with COVID-2019 infection. Clinical chemistry and laboratory medicine, 58(7), 1131–1134. https://doi.org/10.1515/cclm-2020-0198

Lokken, E. M., Walker, C. L., Delaney, S., Kachikis, A., Kretzer, N. M., Erickson, A., Resnick, R., Vanderhoeven, J., Hwang, J. K., Barnhart, N., Rah, J., McCartney, S. A., Ma, K. K., Huebner, E. M., Thomas, C., Sheng, J. S., Paek, B. W., Retzlaff, K., Kline, C. R., Munson, J., … Adams Waldorf, K. M. (2020). Clinical characteristics of 46 pregnant women with a severe acute respiratory syndrome coronavirus 2 infection in Washington State. American journal of obstetrics and gynecology, 223(6), 911.e1–911.e14. https://doi.org/10.1016/j.ajog.2020.05.031

London, V., McLaren, R., Jr, Atallah, F., Cepeda, C., McCalla, S., Fisher, N., Stein, J. L., Haberman, S., & Minkoff, H. (2020). The Relationship between Status at Presentation and Outcomes among Pregnant Women with COVID-19. American journal of perinatology, 37(10), 991–994. https://doi.org/10.1055/s-0040-1712164

Lu, R., Zhao, X., Li, J., Niu, P., Yang, B., Wu, H., Wang, W., Song, H., Huang, B., Zhu, N., Bi, Y., Ma, X., Zhan, F., Wang, L., Hu, T., Zhou, H., Hu, Z., Zhou, W., Zhao, L., Chen, J., … Tan, W. (2020). Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet (London, England), 395(10224), 565–574. https://doi.org/10.1016/S0140-6736(20)30251-8

Ludvigsson J. F. (2020). Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults. Acta paediatrica (Oslo, Norway : 1992), 109(6), 1088–1095. https://doi.org/10.1111/apa.15270.

Maggi, E. F., Magalhães, L. C., Campos, A. F., & Bouzada, M. C. (2014). Preterm children have unfavorable motor, cognitive, and functional performance when compared to term children of preschool age. Jornal de pediatria, 90(4), 377–383. https://doi.org/10.1016/j.jped.2013.10.00533.

Monteil, V., Kwon, H., Prado, P., Hagelkrüys, A., Wimmer, R. A., Stahl, M., Leopoldi, A., Garreta, E., Hurtado Del Pozo, C., Prosper, F., Romero, J. P., Wirnsberger, G., Zhang, H., Slutsky, A. S., Conder, R., Montserrat, N., Mirazimi, A., & Penninger, J. M. (2020). Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2. Cell, 181(4), 905–913.e7. https://doi.org/10.1016/j.cell.2020.04.004

Peng, Z., Wang, J., Mo, Y., Duan, W., Xiang, G., Yi, M., Bao, L., & Shi, Y. (2020). Unlikely SARS-CoV-2 vertical transmission from mother to child: A case report. Journal of infection and public health, 13(5), 818–820. https://doi.org/10.1016/j.jiph.2020.04.004

Schardt, C., Adams, M. B., Owens, T., Keitz, S., & Fontelo, P. (2007). Utilization of the PICO framework to improve searching PubMed for clinical questions. BMC medical informatics and decision making, 7, 16. https://doi.org/10.1186/1472-6947-7-16

Skrablin, S., Lovric, H., Banovic, V., Kralik, S., Dijakovic, A., & Kalafatic, D. (2007). Maternal plasma interleukin-6, interleukin-1beta and C-reactive protein as indicators of tocolysis failure and neonatal outcome after preterm delivery. The journal of maternal-fetal & neonatal medicine: the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 20(4), 335–341. https://doi.org/10.1080/14767050701227877

Wang, S., Guo, L., Chen, L., Liu, W., Cao, Y., Zhang, J., & Feng, L. (2020). A Case Report of Neonatal 2019 Coronavirus Disease in China. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 71(15), 853–857. https://doi.org/10.1093/cid/ciaa225

Wang, F., Nie, J., Wang, H., Zhao, Q., Xiong, Y., Deng, L., Song, S., Ma, Z., Mo, P., & Zhang, Y. (2020). Characteristics of Peripheral Lymphocyte Subset Alteration in COVID-19 Pneumonia. The Journal of infectious diseases, 221(11), 1762–1769. https://doi.org/10.1093/infdis/jiaa150

Whittemore, R., & Knafl, K. (2005). The integrative review: updated methodology. Journal of advanced nursing, 52(5), 546–553. https://doi.org/10.1111/j.1365-2648.2005.03621.x

Xiong, X., Wei, H., Zhang, Z., Chang, J., Ma, X., Gao, X., Chen, Q., & Pang, Q. (2020). Vaginal delivery report of a healthy neonate born to a convalescent mother with COVID--19. Journal of medical virology, 92(9), 1657–1659. https://doi.org/10.1002/jmv.25857

Yu, N., Li, W., Kang, Q., Xiong, Z., Wang, S., Lin, X., Liu, Y., Xiao, J., Liu, H., Deng, D., Chen, S., Zeng, W., Feng, L., & Wu, J. (2020). Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: a retrospective, single-centre, descriptive study. The Lancet. Infectious diseases, 20(5), 559–564. https://doi.org/10.1016/S1473-3099(20)30176-6

Zeng, L., Xia, S., Yuan, W., Yan, K., Xiao, F., Shao, J., & Zhou, W. (2020). Neonatal Early-Onset Infection With SARS-CoV-2 in 33 Neonates Born to Mothers With COVID-19 in Wuhan, China. JAMA pediatrics, 174(7), 722–725. https://doi.org/10.1001/jamapediatrics.2020.0878

Zhao, X., Jiang, Y., Zhao, Y., Xi, H., Liu, C., Qu, F., & Feng, X. (2020). Analysis of the susceptibility to COVID-19 in pregnancy and recommendations on potential drug screening. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 39(7), 1209–1220. https://doi.org/10.1007/s10096-020-03897-6

Zhou, P., Yang, X. L., Wang, X. G., Hu, B., Zhang, L., Zhang, W., Si, H. R., Zhu, Y., Li, B., Huang, C. L., Chen, H. D., Chen, J., Luo, Y., Guo, H., Jiang, R. D., Liu, M. Q., Chen, Y., Shen, X. R., Wang, X., Zheng, X. S., … Shi, Z. L. (2020). A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature, 579(7798), 270–273. https://doi.org/10.1038/s41586-020-2012-7

Zhu, H., Wang, L., Fang, C., Peng, S., Zhang, L., Chang, G., Xia, S., & Zhou, W. (2020). Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia. Translational pediatrics, 9(1), 51–60. https://doi.org/10.21037/tp.2020.02.06

Downloads

Published

01/01/2021

How to Cite

SILVA, J. V. F. da; HEIMER, M. V.; FIGUEIREDO, L. M.; PUGLIESI, D. M. C.; MOREIRA, A. R. O.; PORTO, I. C. C. de M. .; LIMA, F. J. C. de; ROMÃO, D. A. .; SANTOS JUNIOR, V. E. dos. Neonatal outcomes of pregnant women diagnosed with SARS-CoV-2: an integrative review. Research, Society and Development, [S. l.], v. 10, n. 1, p. e0510110905, 2021. DOI: 10.33448/rsd-v10i1.10905. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/10905. Acesso em: 23 nov. 2024.

Issue

Vol. 10 No. 1

Section

Review Article

License

Copyright (c) 2021 João Victor Farias da Silva; Mônica Vilela Heimer; Laura Mello Figueiredo; Daniela Maria Carvalho Pugliesi; Ana Regina Oliveira Moreira; Isabel Cristina Celerino de Moraes Porto; Fernando José Camello de Lima; Dayse Andrade Romão; Valdeci Elias dos Santos Junior

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.