Factors associated with cure and abandonment of leprosy treatment: A reflective analysis
DOI:
https://doi.org/10.33448/rsd-v10i1.11615Keywords:
Primary Health Care; Public health; Epidemiology; Leprosy.Abstract
To analyze trends, and the main socioeconomic and clinical factors related to treatment abandonment and the cure of leprosy in Sergipe. For the present study, data from all new cases of cure and abandonment of leprosy treatment notified by the health centers of the municipalities to the SINAN (Information System on Notifiable Diseases) in the state of Sergipe, Brazil, from 2007 to 2017, were used. This is an ecological study of cases of cure and abandonment of leprosy treatment, rates were calculated based on the "Guidelines for surveillance, care and elimination of leprosy as a public health problem".using time-series analysis and multivariate logistic regression. Concerning multivariate regression, the young age group presents a higher risk for quitting the treatment (p = 0.429; OR = 2.75). Blacks/browns/indigenous were more likely to abandon treatment (p = 0.482; OR = 1.69), as well as multibacillary individuals (p = 0.541; OR = 2.26). Regarding the cure, the young age group has less chances of cure (OR = 0.34). The same happens for the operational classification; the multibacillary patients have a lower chance of cure (OR = 0.35). Finally, individuals with grade 2 of physical disability are less likely to be cured (OR = 0.54). Health services are noticeably weak, especially when it comes to clinical factors associated with treatment abandonment and a low proportion of cure. Multibacillary (Borderline and Lepromatous) are responsible for the active transmission of leprosy.
References
Alencar, C. H. M., Ramos Jr, A. N., Sena Neto, S. A., Murto, C., Alencar, M. J. F., Barbosa, J. C., et al.(2012). Diagnosis of leprosy outside the municipality of residence: a spatial approach, 2001 to 2009. Cad Saude Publica. 28 (9), 1685-98
Araújo, M. M., Silva, J. H. S., Gomes, A. C. S. (2014). Clinical and epidemiological profile of patients who dropped out leprosy treatment. Hansen Int . 39 (2), 55-63.
Barbosa, J. C., Junior, A. N. R., Alencar, O. M. (2014). Leprosy after release from treatment in the Brazilian Unified Health System: aspects for access in the Northeast region. Cad. Saúde Colet.22 (4): 351-8.
Boygni, R. N., Souza, E. A., Romanholo, H. S. B,, et al. (2019). Persistence of leprosy in household social networks: overlapping cases and vulnerability in endemic regions in Brazil. Cad. Saúde Pública, 35(2), 14.
Brazil. (2016) A. Ministry of Health, Secretariat of Health Surveillance, Department of Communicable Diseases. Guidelines for surveillance, care and elimination of leprosy as a public health problem: technical-operational manual [Internet]. Brasília
Brazil (2018) B. Ministry of Health. Health Surveillance Secretary. Characterization of the epidemiological situation of leprosy and differences by sex, Brazil, 2012-2016. Epidemiological bulletin. 49(4), 1-12.
Brazilian Institute of Geography and Statistics (IBGE) (2019). Cities @ Sergipe. 2019
Brito, A. L., Monteiro, L. D., Ramos Junior, A. N., Heukelbach, J., Alencar, C. H. (2018). Temporal trends of leprosy in a Brazilian state capital in Northeast Brazil: epidemiology and analysis by joinpoints, 2001 to 2012. Rev Bras Epidemiol.19(1):194-204.
Cabral-Miranda, W., Chiaravalloti, N. F., & Barrozo, L. V. (2014). Socioeconomic and environmental effects influencing the development of leprosy in Bahia, northeastern Brazil. Trop Med Int Health. 19(12), 1504-14
Heukelbach, J., Chichava, A. O., & Oliveira, A. R. (2011). Interruption and Defaulting of Multidrug Therapy against Leprosy: Population-Based Study in Brazil’s Savannah Region. Plos. Neglected Tropical Diseases. 5(5), 1-9
Ignotti, E., Andrade, V. L. G., Sabroza, P. C., & Araújo, A. J. G. (2001). Study of adherence to leprosy treatment in the city of Duque de Caxias / RJ. "Abandonment or Abandoned". Hansenologia Internationals. 26(11), 23-30
Lapa, T. M., Albuquerque, M. F. P. M., Carvalho, M. F., et al.(2006). Spatial analysis of leprosy cases treated at public health care facilities in Brazil. Cad. Saúde Pública. 22(12):2575-2583
Lira, R. M. N., Silva, M. V. S., & Gonçalves, G. B. (2017). Factors related to abandonment or interruption of leprosy treatment: an integrative literature review. Rev Enferm UFPI, 6(4),53-8
Loyal, D. R., Cazarin, G., Bezerra, L. C. A., et al. (2017). Leprosy Control Program: Assessment Of Implementation In Districts. Health Debate. 41, 209-228.
Luna, I. T., Beserra, E. P., Alves, M. D. S., & Pinheiro, P. N. C. (2010). Adhesion to Leprosy treatment: inherent difficulties of the patients. Rev Bras Enferm. 63(6), 983-90.
Monteiro, L. D., Martins-Melo, F. R., Brito, A. L., Alencar, C. H., Heukelbah, J. (2015). Spatial patterns of leprosy in a hyperendemic state in Northern Brazil, 2001-2012. Rev Saúde Pública 49(84), 1-8.
Monteiro, L. D., et al.(2017). Social determinants of leprosy in a hyper-endemic state in northern Brazil. Rev Saude Publica, 51(70), 1-12
Naaz, F., Mohanty, P. S., Bansal, A. K., et al.(2017) Challenges Beyond Elimination in Leprosy. Int J Mycobacteriol. 6(3), 222-228.
Noriega, L. F., Chiacchio, N. D., Noriega, A. F., Pereira, G. A., & Vieira, M. (2016). Leprosy: ancient disease remains a public health problem nowadays. An Bras Dermatol .91, 547-8
Oliveira, K. S., Souza, J., Zilly, A., Silva-Sobrinho, R. A. (2015). Evaluation of leprosy epidemiological and operational indicators in priority municipalities in the state of Paraná, 2001 to 2010. Epidemiol Serv Saude. 24(3), 507-16
Ribeiro, M. D. A., Silva, J. C. A., Oliveira, S. B. (2018) Epidemiologic study of leprosy in Brazil: reflections on elimination goals. Rev Panam Salud Publica. 42(7), 7.
Rodrigues, A. L. P., Almeida, A. P., Rodrigues, B. F., et al.(2000). Occurrence of late lepra reaction in leprosy pacients: subsidies for implementation of a specific care program. Hansen. Int.. 25(1), 7-16.
Santos, M. B., Santos, A. D., Barreto, A. S., et al.(2019). Clinical and epidemiological indicators and spatial analysis of leprosy cases in patients under 15 years old in an endemic area of Northeast Brazil: an ecological and time series study. BMJ Open. 9(7): e023420.
Sousa, A. A., Oliveira, F. J. F., Costa, A. C. P. J, et al.(2013). Adhesion to Hansen’s Disease Treatment for Patients monitored at basic Health Units in Impertatriz-MA. Sanare, Sobral, 12(1), 06-12
Souza, C. D. F., Luna, C. F., & Magalhães, C. A. F. (2019). Leprosy transmission in Bahia, 2001-2015: modeling based on Joinpoint regression and spatial scan statistics. Epidemiol. Serv. Saude. . 28(1). e2018065
Souza, E. A., Ferreira, A. F., Boigny, R. N., et al. (2018). Leprosy and gender in Brazil: trends in an endemic area of the Northeast region, 2001–2014. Rev. Saúde Pública. 52, 20.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Thayane Santos Siqueira; Ariel Oliveira Celestino; José Rodrigo Santos Silva
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
