Prevalence of reactivity to total anti-hbc (IgM, IgG) in blood donation candidates in a region of northeastern Brazil
DOI:
https://doi.org/10.33448/rsd-v10i9.18337Keywords:
Hepatitis B; Anticuerpos; Donantes de sangre; Serología.Abstract
Over the past few years, several advances have taken place in transfusion medicine, as well as the development of laboratory techniques used in the serological screening of blood donors, aiming to minimize the transmission of infectious diseases. The importance of detecting total anti-HBc aims to aid in the differential diagnosis of hepatitis, following hepatitis B virus (HBV) infection together with other viral markers, being used in blood banks as a screening test for blood donors, showing efficacy in detecting prior contact with HBV during the “negative window” of HBV. The aim of this study was to evaluate the serological profile for hepatitis B (total anti-HBc) in blood donation candidates in a region of northeastern Brazil. A cross-sectional study was carried out, of qualitative approach, with the computerization system of the entire blood donation cycle, with retrospective data and categorized according to sex, age, location, level of education and risk behavior, having as target population candidates for blood donation in the period from January 2016 to December 2020. Of the 136,652 candidates for donation, reactivity to total anti-HBc was observed in 2.69% (N=3,681). There was greater reactivity to total anti-HBc among male candidates 2.70% (n=2,912) and aged between 29 and 39 years, with 54.9% (n=2,024) living in the interior of the state and one total of 0.91% (n=1,247) with incomplete elementary school. Clinical, laboratory and serological pre-screening for the hepatitis B virus in blood donation candidates is a safety protocol for the transfusion procedure. Aiming to increase the reduction of the risks of contamination and loss of supplies used for the donation, it is necessary to mobilize vaccination campaigns for the hepatitis B virus, and for all those who apply to donate blood at Blood Centers.
References
Abdool, K.S.S., Coovadia, H.M., Windsor, I.M., Thejpal, R. Ende, J. & Fouche, A. (1998). The Prevalence and transmission of hepatitis B virus infection in urban, rural and institutionalized black children of Natal/ KwaZulu, South Africa. International Journal of Epidemiology. 17, 168-173.
ANVISA - Agência Nacional de Vigilância Sanitária. Relatório de produção de 2000. <http://www.anvisa.gov.br/sangue/hemoterapia/produção.htm.>
Brasil, Ministério Da Saúde. (2015). Manual Técnico para o Diagnóstico das Hepatites Virais.
Brasil, Ministério da Saúde. (2016). Portaria nº 158, de 4 de fevereiro de 2016. Redefine o regulamento técnico de procedimentos hemoterápicos. Diário Oficial da União. 5,1,37.
Brasil, Ministério da Saúde. (2017). Boletim Epidemiológico de Hepatites Virais. Secretaria de Vigilância em Saúde.
Brasil, Ministério da Saúde. (2017). Secretaria de Vigilância em Saúde. Departamento de Vigilância, Prevenção e Controle das Infecções Sexualmente Transmissíveis, do HIV/ Aids e das Hepatites Virais. Protocolo Clínico e Diretrizes Terapêuticas para Hepatite B e Coinfecções.
Brasil, Ministério Da Saúde. (2018). Boletim Epidemiológico Hepatites Virais 2018. 1(49).
Brasil. Ministério da Saúde. (2018). Manual Técnico para o Diagnóstico das Hepatites Virais / Ministério da Saúde, Secretaria de Vigilância em Saúde, Departamento de Vigilância, Prevenção e Controle das IST, do HIV/Aids e das Hepatites Virais. – Brasília.
Busch, M. P., Bloch, E. M. & Kleinman, S. (2019). Prevention of transfusion-transmitted infections. Blood. 133(17), 1854-64.
Carlesso, L., Guimarães, R. F. S., Silva, S. L., Santos, C. F., Viero, V., Vieira, S. V. & Girardon-Perlini, N. M. O. (2017). Strategies Implemented in Hemotherapy Services to Increase Blood Donation. Rev Bras Promoç Saúde. 30(2), 213-220.
CDC - Centers for disease control and prevetion. (2020). Hepatitis B. Disponível em: https://www.cdc.gov/hepatitis/hbv/index.htm
Covas, D.T (2013). Doenças Infecciosas Transmissíveis por Transfusões Sanguíneas. Tratado de Hematologia.767–770.
Fonseca, J.C.F. (2007). História natural da hepatite crônica B. Rev Soc Bras Med Trop. 40(6), 672-7.
Houareau, C. & Offergeld, R. (2019). Anti-HBc screening – is it worth the effort? Results of a 10-year surveillance programme covering more than 30 million donations in Germany. Vox Sang. 114(5), 459-66.
Ismail, A. M. et al. (2011). Performance characteristics and comparison of Abbott and artus real- -time systems for hepatitis B virus DNA quantification. Journal of clinical microbiology. 49(9), 3215-21.
Martins, T. S. & Nóbrega, J. O. T. (2018). Segurança transfusional no Brasil: dos primórdios ao NAT. Revista Brasileira de Analises clinicas- RBAC. 50(4), 321- 6.
Okoroiwu, H. U., Okafor, I. M., Asemota, E. A. & Okpokam, D, C. (2018). Seroprevalence of transfusion-transmissible infections (HBV, HCV, syphilis and HIV) among prospective blood donors in a tertiary health care facility in Calabar, Nigeria; an eleven years evaluation. BMC Public Health. 18(1), 645.
Padillha, D. Z. & Witt, R. R. (2011). Competências da enfermeira para a triagem clínica de doadores de sangue. Revista Brasileira de Enfermagem. 64(2), 234-40.
Santos, N. L. P. & Stipp, M. C. (2011). O itinerário de doadores de sangue: reflexões acerca da micropolítica no cuidado de enfermagem. Physis. Revista de Saúde Coletiva. 21(1), 283-298.
WHO - World Health Organization. (2017). Hepatitis A outbreaks mostly affecting men who have sex with men: European Region and the Americas.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Weber de Santana Teles; Max Cruz da Silva; Paulo Celso Curvelo Santos Junior; Ruth Cristini Torres; Marcel Vinícius Cunha Azevedo; Ângela Maria Melo Sá Barros; Alejandra Debbo; Ana Fátima Souza Melo de Andrade; André Luiz de Jesus Morais; Taíssa Alice Soledade Calasans; Maria Hozana Santos Silva
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
