Genetic polymorphism of TNF-α and its implications in previewing the course of pathologies, including oral diseases
DOI:
https://doi.org/10.33448/rsd-v10i11.18521Keywords:
Cell-free nucleic acids; Polymorphism genetic; Polymorphism single nucleotide; Periodontitis.Abstract
Objective: the aim of this work was to explain the implications of the genetic profile (TNF-α polymorphisms in the region-308) in the outcome of different pathologies; and explain how this profile is obtained in the laboratory. Methodology: The salting out technique, according to Miller et al. (1988) was used to explain the reader how the genetic profile of TNF-α is obtained to foresee the outcome of pathologies that are modulated by this cytokine. Results: the product of the amplified digestion of TNF-α genes was obtained, photographed and explained for the reader. Conclusions: the genetic profile may be useful as a predictor for the outcome of different pathologies, so that doctors and dentists may choose the best therapy for each patient.
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Copyright (c) 2021 Luciano Barreto Silva; Rodolfo Scavuzzi Carneiro da Cunha; Gabriel Henrique De Oliveira Queiroz; Guilherme Marinho Sampaio ; Hadassa Fonsêca da Silva ; Sandra Sayão Maia; Paulo Melo Júnior; Edleine Dellalibera ; Ana Paula Veras Sobral
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