Prevalence of histopathological findings of esophageal mucosa and their correlation with Helicobacter pylori

Authors

DOI:

https://doi.org/10.33448/rsd-v11i2.25769

Keywords:

Esophageal mucosa; Histopathology; Helicobacter pylori.

Abstract

Introduction: esophageal pathologies with histopathological changes can cause dyspeptic symptoms, retrosternal and epigastric pain. Objectives: to identify the prevalence of histopathological findings of the esophageal mucosa and to correlate with the bacterium Helicobacter pylori (HP). Methodology: cross-sectional, retrospective study, with 1,953 histopathological reports of the esophageal mucosa. Data analyzed by absolute and relative frequency, Pearson's Chi-Square, Mann-Whitney and Chi-Square Test with Monte-Carlo simulations. Results: 1953 reports of esophageal lesions were analyzed: female gender 982 (50.3%) and median age 44. 151 (7.7%) reports were positive for HP and of these, 41 (2.3%) had gastric atrophy. Esophagitis 1427 (73.1%), metaplasia 548 (28.1%) and Barrett's esophagus 133 (6.8%) were more prevalent. Malignancy, 5 (0.3%) reports. Of the patients with PH: esophagitis 97 (64.2%), Barrett's esophagus 17 (11.3%) and metaplasia 45 (29.8%) - statistically significant pancreatic metaplasia (p<0.001). Two (1.3%) reports showed malignancy associated with PH. Correlating HP with esophageal lesions, there was a tendency to determine a higher risk of the presence of the bacteria: Barrett's esophagus (RR: 1.68 (95%CI: 1.05-2.69), epithelial hyperplasia (RR: 2.18 (RR: 2.18) 95%CI: 1.18-4.02), glycogenic acanthosis (RR: 3.69 (95%CI: 2.08-6.54), polyps (RR: 2.17 (95%CI: 1.14-4, 16), malignancy (RR: 4.91 (95%CI: 1.66-14.52) and gastric atrophy (RR: 3.44 (95%CI: 2.02-5.84). Conclusion: Barrett's esophagus, Epithelial hyperplasia, glycogenic acanthosis, polyps, malignancy and gastric atrophy are associated with an increased risk of the presence of the bacteria.

References

Adachi, K., Notsu, T., Mishiro, T., & Kinoshita, Y. (2019). Long‐term effect of Helicobacter pylori eradication on prevalence of reflux esophagitis. Journal of gastroenterology and hepatology, 34 (11), 1963-1967.

Guccione, C., Yadlapati, R., Shah, S., Knight, R., & Curtius, K. (2021). Challenges in Determining the Role of Microbiome Evolution in Barrett's Esophagus and Progression to Esophageal Adenocarcinoma. Microorganisms, 9 (10), 2003.

Holleczek, B., Schöttker, B., & Brenner, H. (2020). Helicobacter pylori infection, chronic atrophic gastritis and risk of stomach and esophagus cancer: Results from the prospective population‐based ESTHER cohort study. International journal of cancer, 146 (10), 2773-2783.

INCA. (2021). Câncer de esôfago. Instituto Nacional de Câncer. https://www.inca.gov.br/tipos-de-cancer/cancer-de-esofago.

INCA. (2021). Síntese de Resultados e Comentários. Instituto Nacional de Câncer. https://www.inca.gov.br/estimativa/sintese-de-resultados-e-comentarios.

Kaminski, E. D. M. F., & Kruel, C. D. P. (2001). Carcinogênese gástrica. Revista HCPA. 21 (1), 86-97.

Labenz, J., Blum, A. L., Bayerdorffer, E., Meining, A., Stolte, M., & Borsch, G. (1997). Curing Helicobacter pylori infection in patients with duodenal ulcer may provoke reflux esophagitis. Gastroenterology, 112 (5), 1442-1447.

Lv, J., Guo, L., Liu, J. J., Zhao, H. P., Zhang, J., & Wang, J. H. (2019). Alteration of the esophageal microbiota in Barrett's esophagus and esophageal adenocarcinoma. World journal of gastroenterology, 25 (18), 2149.

Na H. K., Lee J. H., Park S. J., Park H. J., Kim S. O., Ahn J. Y., Kim D. H., Jung K. W., Choi K. D., Song H. J., Lee G. H., Jung H. Y. (2020). Effect of Helicobacter pylori eradication on reflux esophagitis and GERD symptoms after endoscopic resection of gastric neoplasm: a single-center prospective study. BMC Gastroenterol. 123 (20).

PDQ Screening and Prevention Editorial Board. (2021). Stomach (Gastric) Cancer Prevention (PDQ®): Health Professional Version. In PDQ Cancer Information Summaries. National Cancer Institute (US).

Ribeiro, P. F. S., Kubrusly, L. F., Nassif, P. A. N., Ribeiro, I. C. S., Bertoldi, A. D. S., & Batistão, V. C. (2016). Relação entre graus de esofagite e o Helicobacter pylori. ABCD Arq Bras Cir Dig. 29 (3), 135-137.

Ronkainen, J., Talley, N. J., Aro, P., Storskrubb, T., Johansson, S. E., Lind, T., Bolling-Sternevald, E., Vieth, M., Stolte, M., Walker, M. M., & Agréus, L. (2007).

Prevalence of oesophageal eosinophils and eosinophilic oesophagitis in adults: the population-based Kalixanda study. Gut, 56 (5), 615-620.

Saad, A. M., Choudhary, A., & Bechtold, M. L. (2012). Effect of Helicobacter pylori treatment on gastroesophageal reflux disease (GERD): meta-analysis of randomized controlled trials. Scandinavian journal of gastroenterology, 47 (2), 129-135.

Schulz, M. K., Biancardi, M. R., Fernandes, D., Almeida, L. Y. de, Bufalino, A., & Leon, J. E. (2018). Glycogenic acanthosis on mouth clinically present as white plaque. RGO, Rev Gaúch Odontol. 66 (3), 274-277.

Schütze, K., Hentschel, E., Dragosics, B., & Hirschl, A. M. (1995). Helicobacter pylori reinfection with identical organisms: transmission by the patients' spouses. Gut, 36 (6), 831-833.

Souza, R. C. A. D. (2007). Estudo da associação entre a esofagite erosiva e a infecção pelo Helicobacter pylori. Universidade Federal do Paraná, Curitiba.

Stern, Z., Sharon, P., Ligumsky, M., Levij, I. S., & Rachmilewitz, D. (1980). Glycogenic acanthosis of the esophagus. A benign but confusing endoscopic lesion. The American journal of gastroenterology, 74 (3), 261-263.

Veiga, F. M. da S., Castro, A. P. B. M., Santos, C. de J. N. dos, Dorna, M. de B., & Pastorino, A. C. (2017). Esofagite eosinofílica: um conceito em evolução? Arquivos de Asma, Alergia e Imunologia, 1 (4), 363–372.

Xia, H. H. X., & Talley, N. J. (1998). Helicobacter pylori infection, reflux esophagitis, and atrophic gastritis: an unexplored triangle. The American journal of gastroenterology, 93 (3), 394-400.

Yang, L., Lu, X., Nossa, C. W., Francois, F., Peek, R. M., & Pei, Z. (2009). Inflammation and intestinal metaplasia of the distal esophagus are associated with alterations in the microbiome. Gastroenterology, 137 (2), 588–597.

Yılmaz, N. (2020). The relationship between reflux symptoms and glycogenic acanthosis lesions of the oesophagus. Przegląd gastroenterologiczny, 15 (1), 39.

Downloads

Published

27/01/2022

How to Cite

SOUZA, G. B. V. de; MOURA, E. R.; TRINDADE, Y. T. D.; SANTANA NETO, D. J. de; MOREIRA, L. G.; CARVALHO, G. P. S. de; BARRETO, Íkaro D. de C.; SILVA, D. F. da; MEURER, L.; TRINDADE, L. M. D. F. Prevalence of histopathological findings of esophageal mucosa and their correlation with Helicobacter pylori. Research, Society and Development, [S. l.], v. 11, n. 2, p. e33811225769, 2022. DOI: 10.33448/rsd-v11i2.25769. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/25769. Acesso em: 23 nov. 2024.

Issue

Vol. 11 No. 2

Section

Health Sciences

License

Copyright (c) 2022 Gabrielle Barbosa Vasconcelos de Souza; Elomar Rezende Moura; Yasmin Tourinho Delmondes Trindade; Durval José de Santana Neto; Larissa Gonçalves Moreira; Gabriel Ponciano Santos de Carvalho; Íkaro Daniel de Carvalho Barreto; Décio Fragata da Silva; Luíse Meurer; Leda Maria Delmondes Freitas Trindade

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.