Opportunistic oral infections in patients submitted to radiotherapy for head and neck cancer: a retrospective study
DOI:
https://doi.org/10.33448/rsd-v9i3.2685Keywords:
Opportunistic infections; Head and neck neoplasm; Oral candidiasis; Radiotherapy; Chemotherapy; Surgery.Abstract
To evaluate retrospectively the prevalence of opportunistic oral infections in head and neck cancer patients submitted to radiotherapy, in combination or not with chemotherapy and surgery. The survey was performed by revision of electronic medical records of patients submitted to 3D-conformational RT for head and neck cancer from the Record Book of Medical Physics of Radiotherapy Division at Federal University of São Paulo (São Paulo Hospital), considering personal and clinical data. Among the 79 patients evaluated, 38 developed an opportunistic oral infection. Besides, most of them were white men, younger than 60 years, ex-smokers, ex-alcoholic, and underwent dental treatment pre-RT. The most frequent histological type was the squamous cell carcinoma and the most affected anatomical site was the larynx. There were also higher rates of stage IV tumors and oncologic treatments performed with a combination of RT, chemotherapy, and surgery. In relation to the opportunistic oral infections, candidiasis was the most representative. Patients with advanced-stage head and neck cancer seem to present oral candidiasis more frequently, probably due to the multimodal treatment.
References
Rubira, C.M.F.; Devides, N.J.; Úbeda, L.T.; Jr Bortolucci, A.G.; Lauris, J.R.; Rubira-Bullen, I.R.F.; Damante, J.H. (2007) Evaluation of some oral postradiotherapy sequelae in patients treated for head and neck tumors. Braz Oral Research, 21, 272-277.
Specht, L. (2002) Oral complications in the head and neck radiation patient. Introduction and scope of the problem. Support Care Cancer, 10, 36-39.
Ruback, M.J.C.; Galbiatti, A.L.; Arantes, L.M.R.B.; Marucci, G.H.; Russo, A.; Ruiz-Cintra, M.T.; Raposo, L.S.; Maniglia, J.V.; Pavarino, E.C.; Goloni-Bertollo, E.M. (2002) Clinical and epidemiological characteristics of patients in the head and neck surgery department of a university hospital. São Paulo Med J, 130, 307-313.
Brasil. Ministério da Saúde. Instituto Nacional de Câncer (2019). Estimativa 2020: incidência de câncer no Brasil. Rio de Janeiro: INCA.
Palma, L.F.; Gonnelli, F.A.S.; Marcucci, M.; Dias, R.S.; Giordani, A.J.; Segreto, R.A.; Segreto, H.R.C. (2017) Impact of low-level laser therapy on hyposalivation, salivary pH, and quality of life in head and neck cancer patients post-radiotherapy. Lasers Med Sci, 32, 827-832.
Palma, L.F.; Gonnelli, F.A.S.; Marcucci, M.; Dias, R.S.; Giordani, A.J.; Segreto, R.A.; Segreto, H.R.C (2018) A novel method to evaluate salivary flow rates of head and neck câncer patients after radiotherapy: a pilot study. Braz J Otorhinolaryngol, 84, 227-231.
Gonnelli, F.A.S.; Palma, L.F.; Giordani, A.J.; Deboni, A.L.; Dias, R.S.; Segreto, R.A.; Segreto, H.R.C (2016) Low-level laser for mitigation of low salivary flow rate in head and neck cancer patients undergoing radiochemotherapy: a prospective longitudinal study. Photomed Laser Surg, 34, 326-330.
Gonnelli, F.A.S.; Palma, L.F.; Giordani, A.J.; Deboni, A.L.; Dias, R.S.; Segreto, R.A.; Segreto, H.R.C (2016) Low-level laser therapy for the prevention of low salivary flow rate after radiotherapy and chemotherapy in patients with head and neck cancer. Radiol Bras, 49, 86-91.
Rosenthal, D.I.; Trotti, A. (2009) Stragies for managing radiation-indeced mucosites in head and neck cancer. Semin radiot Oncol, 19, 29-34.
Jensen, S.B.; Pedersen, A.M.; Reibel, J. (2003) Xerostomia and hypofunction of the salivary glands in cancer therapy. Support Care Cancer, 11, 207-225.
Homer, J.J. (2016) Surgery in head and neck cancer: United Kingdom national multidisciplinary guidelines. J Laryngol Otol, 13, 68-70.
Paiva, C.I. (2004) Efeitos da quimioterapia na cavidade bucal. Discip Sci Sér Ciênc Biol Saúde, 4, 109-119.
Goursand, D. (2006) Sequelas bucais em crianças submetidas à terapia antineoplásica: causas e definição do papel do cirurgião dentista. Arq Odontol, 42, 161-256.
Vietzke, W.M.; Gelderman, A.H.; Grimley, P.M.; Valsamis, M.P. (1986) Toxoplasmosis complicating malignancy. Experience at the National Cancer Institute. Cancer, 21, 816-827.
Luna, O.B. (2007) Estrongiloidíase disseminada: diagnóstico e tratamento. Rev Bras Ter Intensive, 19, 463-468.
Sesterhenn, A.M.; Püftzner, W.; Braulke, D.M.; Wiegand, S.; Werner, J.A.; Taubert, A. (2009) Cutaneous manifestation of myiasis in malignant wounds of head and deck. Eur J Dermatol, 19, 64-68.
Melo Filho, M.R.; Rocha, B.A.; Pires, M.B.O.; Fonseca, E.S.; de Freitas, E.M.; Martelli Junior, H., Santos, F.B.G. (2013) Qualidade de vida de pacientes com carcinoma em cabeça e pescoço. Braz J Otorhinolaryngol, 79, 82-88.
Sroussi, H.Y.; Epstein, J.B.; Bensadoun, R.J.; Saunders, D.P.; Lalla, R.V.; Migliorati, C.A.; Heaivilin, N.; Zumsteg, Z.S. (2017) Common oral complications of head and neck cancer radiation therapy: mucositis, infections, saliva change, fibrosis, sensory dysfunctions, dental caries, periodontal disease, and osteoradionecrosis. Cancer Med, 6, 2918-2931.
Rocha, F.G.C.W.; Dantas, J.B.L.; Martins, G.B.; Lima, H.R.; Carrera, M.; Medrado, A.R.A.P. (2017) Ocorrência de candidíase oral em pacientes portadores de câncer de cabeça e pescoço submetidos aos tratamentos antineoplásicos. Rev Ciênc Méd Biol, 16, 318-322.
Rocha, B.Q.C.; Eneas, L.; de Oliveira, R.G.; Verner, F.S.; Junqueira, R.B. (2017) Características epidemiológicas de pacientes portadores de neoplasia de cabeça e pescoço submetidos à radioterapia em Juiz de Fora – MG. HU Revista, 43, 71-75.
Alvarenga, L.M.; Ruiz, M.T.; Pavarino-Bertelli, E.C.; Ruback, M.J.C.; Maniglia, J.V.; Goloni-Bertollo, E.M. (2008) Avaliação epidemiológica de pacientes com câncer de cabeça e pescoço em um hospital universitário do noroeste do estado de São Paulo. Rev Bras Otorrinolaringol, 74, 68-73.
Sociedade Brasileira de Cirurgia de Cabeça e Pescoço (SBCCP). Álcool e cigarro multiplicam o risco de câncer de cabeça e pescoço. Acesso em 14 de fevereiro em http://www.sbccp.org.br/?p=2317
Galbiatti, A.L.S.; Padovani-Junior, J.Á.; Maniglia, J.V.; Rodrigues, C.D.S.; Pavarino, E.C.; Goloni-Bertolo, E.M. (2013) Câncer de cabeça e pescoço: causas prevenção e tratamento. Braz J Otorhinolaryngol, 79, 239-247.
Salazar, M.; Victorino, F.R.; Paranhos, L.R.; Ricci, I.D.; Gaetti, W.P.; Caçador, N.P. (2008) Efeitos e tratamento da radioterapia de cabeça e pescoço de interesse ao cirurgião dentista-Revisão da literatura. Odontol, 16, 62-68.
Santos, R.A.; Portugal, F.B.; Felix, J.D.; dos Santos, P.M.O.; Siqueira, M.M. (2012) Avaliação epidemiológica de pacientes com câncer no trato aerodigestivo superior: Relevância dos fatores de risco álcool e tabaco. Rev Bras Cancerol, 58, 21-29.
Singh, G.K.; Capoor, M.R.; Nair, D.; Bhowmik, K.T. (2017) Spectrum of fungal infection in head and neck cancer patients on chemoradiotherapy. J Egypt Natl Canc Inst, 29, 33-37.
Kauffman, C.A. (2005) Candidíase. Cecil: Tratado de Medicina Interna. Rio de Janeiro: Elsevier.
Neville, B.W.; Damm, D.D.; Allen, C.M. (2009) Patologia oral e maxilofacial. Rio de Janeiro: Guanabara Kogan.
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