Incidence of venous thromboembolic events in patients diagnosed with COVID-19: A literature review
DOI:
https://doi.org/10.33448/rsd-v11i5.28273Keywords:
COVID-19; Venous thromboembolism; Deep venous thrombosis; Pulmonary embolism.Abstract
Since the beginning of the pandemic caused by sars-cov-2, attempts have been made to elucidate the mechanism of action of the virus and its consequences in the human body. There is a relationship between the infection caused by the virus and the process of hypercoagulability, corroborating the occurrence of vascular events during the course of the disease, especially in critically ill patients. The objective of the study is to elucidate the incidence of venous vascular events through a literature review, in addition to highlighting the dynamics of the D-dimer marker in the prognosis of the disease. The methodology used for this scientific investigation was of a basic nature, with the objective of recording and describing the observed facts, adopting a qualitative approach, through a bibliographic review on different digital platforms. It was noticed that there was a high incidence of venous thromboembolism in patients diagnosed with COVID-19, being higher in patients who were in an intensive care unit. The manifestation occurred in two ways, as Deep Vein Thrombosis (DVT), which usually occurs in the lower limbs, and as Pulmonary Embolism (PE), being clots that travel through the blood circulation of the lung. The increase in the D-dimer marker was related to an indicator of poor prognosis during the course of infection. The increase was more pronounced in critically ill patients and in those who died. Therefore, questions about the incidence of VTE in patients affected by COVID-19 are scored so that, in this way, one can have a better understanding of the implications of these in the follow-up of patients.
References
Artifoni, M., Danic G., Gautier, G. et al. (2020). Systematic assessment of venous thromboembolism in COVID-19 patients receiving thromboprophylaxis: incidence and role of D-dimer as predictive factors. J Thromb Thrombolysis. 2020;50(1):211-216. doi:10.1007/s11239-020-02146-z
Belasco, A. G. S. & Fonseca, C. D. da. (2020). Coronavírus 2020. Revista Brasileira de Enfermagem. Brasília, v. 73, n. 2.
Berto, S. J. P., Carvalhares, M. A. B. L. & Moura, E. C. de. (2010). Tabagismo associado a outros fatores comportamentais de risco de doenças e agravos crônicos não transmissíveis. Cadernos de Saúde Pública [online]. 2010, v. 26, n. 8. 1573-1582. https://doi.org/10.1590/S0102-311X2010000800011>. Epub 27 Ago 2010. ISSN 1678-4464. https://doi.org/10.1590/S0102-311X2010000800011.
Beun, R., Kusadasi, N., Sikma, M., Westerink, J. & Huisman, A. (2020). Thromboembolic events and apparent heparin resistance in patients infected with SARS-CoV-2. Int J Lab Hematol. 2020;42 Suppl 1(Suppl 1):19-20. doi:10.1111/ijlh.13230
Bilaloglu, S., Aphinyaphongs, Y., Jones, S., Iturrate, E., Hochman, J. & Berger, J. S. (2020). Thrombosis in Hospitalized Patients With COVID-19 in a New York City Health System. JAMA. 2020;324(8):799-801. doi:10.1001/jama.2020.13372
Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. Protocolo de Manejo Clínico para o Novo Coronavírus (2019-nCoV) - Mar, 2020. https://www.saude.ms.gov.br/wp-content/uploads/2020/03/protocolo-manejo-coronavirus.pdf.
Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. Guia de Vigilância Epidemiológica - Emergência de Saúde Pública de Importância Nacional pela Doença pelo Coronavírus 2019. https://portalarquivos.saude.gov.br/images/af_gvs_coronavirus_6ago20_ajustes-finais-2.pdf.
Casella, I. B. (2020). Fisiopatologia da trombose associada à infecção pelo SARS-CoV-2. Jornal Vascular Brasileiro. Porto Alegre, v. 19, e20200128, 2020. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-54492020000100204&lng=en&nrm=iso>. Epub Sep 21, 2020.
Criel, M., Falter, M., Jaeken, J. et al. (2020). Venous thromboembolism in SARS-CoV-2 patients: only a problem in ventilated ICU patients, or is there more to it?. Eur Respir J. 2020;56(1):2001201. Published 2020 Jul 30. doi:10.1183/13993003.01201-2020
Cui, S., Chen, S., Li, X., Liu, S. & Wang, F. (2020). Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia. J Thromb Haemost. 2020;18(6):1421-1424. doi:10.1111/jth.14830
Desborough, M. J. R., Doyle, A. J., Griffiths, A., Retter, A., Breen, K. A. & Hunt, B.J. (2020). Image-proven thromboembolism in patients with severe COVID-19 in a tertiary critical care unit in the United Kingdom. Thromb Res. 2020;193:1-4. doi:10.1016/j.thromres.2020.05.049
Dubois-Silva Á., Barbagelata-López C., Mena Á., Piñeiro-Parga P., Llinares-García D. & Freire-Castro S. (2020). Pulmonary embolism and screening for concomitant proximal deep vein thrombosis in noncritically ill hospitalized patients with coronavirus disease 2019. Intern Emerg Med. 2020;15(5):865-870. doi:10.1007/s11739-020-02416-x
Fernández-Capitán, C., et al. (2020). Presenting Characteristics, Treatment Patterns, and Outcomes among Patients with Venous Thromboembolism during Hospitalization for COVID-19. Published 2020 May 3; doi: 10.1055/s-0040-1718402
Freire, J. F. B., Flores, S. S. T., Guerreiro, & M. A. B. (2020). SARS-CoV-2 y enfermedad tromboembólica venosa. No todo es nuevo. Angiología, Madrid, v. 72, n. 6, p. 286-297, dic. 2020. http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0003-31702020000700002&lng=es&nrm=iso>. Epub 01-Feb-2021. https://dx.doi.org/10.20960/angiologia.00173.
Gil, A. C. (2008). Métodos e técnicas de pesquisa social. 6. ed. São Paulo: Atlas.
Grandmaison, G., Andrey, A., Périard, D. et al. (2020). Systematic Screening for Venous Thromboembolic Events in COVID-19 Pneumonia. TH Open. 2020;4(2):e113-e115. Published 2020 Jun 8. doi:10.1055/s-0040-1713167
Habas, K., Nganwuchu, C., Shahzad, F., Gopalan, R., Haque, M., Rahman, N. S., Majumder, A. A. & Nasim, T. (2020). Resolution of coronavirus disease 2019 (COVID-19). Expert Rev Anti Infect Ther. 2020 Dec;18(12):1201-1211. doi: 10.1080/14787210.2020.1797487. Epub 2020 Aug 4. PMID: 32749914.
Helms, J., Tacquard, C., Severac, F. et al. (2020). High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study. Intensive Care Med. 2020;46(6):1089-1098. doi:10.1007/s00134-020-06062-x
Hippensteel, J.A., Burnham, E.L. & Jolley, S. E. (2020). Prevalence of venous thromboembolism in critically ill patients with COVID-19. Br J Haematol. 2020;190(3):e134-e137. doi:10.1111/bjh.16908
Iba T.; Connors, J. M.; Levy, J. H. (2020). The coagulopathy, endotheliopathy, and vasculitis of COVID-19. Inflamm Res. 2020 Dec;69(12):1181-1189. doi: 10.1007/s00011-020-01401-6. Epub 2020 Sep 12. PMID: 32918567; PMCID: PMC7486586.
Jiménez, D., García-Sanchez, A., Rali, P. et al. (2020). Incidence of VTE and Bleeding Among Hospitalized Patients With Coronavirus Disease 2019: A Systematic Review and Meta-analysis. Chest. 2021;159(3):1182-1196. doi:10.1016/j.chest.2020.11.005
Klok, F.A., Kruip, M. J. H. A., Van Der Meer, N. J. M. et al. (2020). Confirmation of the high cumulative incidence of thrombotic complications in critically ill ICU patients with COVID-19: An updated analysis. Thromb Res. 2020;191:148-150. doi:10.1016/j.thromres.2020.04.041
Lima, C. M. A. de O. (2020). Information about the new coronavirus disease (COVID-19). Radiologia Brasileira [online]. 2020, v. 53, n. 2. Acesso em 2 de junho 2021, pp. V-VI. https://doi.org/10.1590/0100-3984.2020.53.2e1>. Epub 17 Abr 2020. ISSN 1678-7099. https://doi.org/10.1590/0100-3984.2020.53.2e1.
Lima, C. M. A. de O. (2020). Informações sobre o novo coronavírus (COVID-19). Radiol Bras, São Paulo, v. 53, n. 2, pág. V-VI, abril de 2020. <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-39842020000200001&lng=en&nrm=iso>. Epub 17 de abril de 2020.
Llitjos, J.F., Leclerc, M., Chochois, C. et al. (2020). High incidence of venous thromboembolic events in anticoagulated severe COVID-19 patients. J Thromb Haemost. 2020;18(7):1743-1746. doi:10.1111/jth.14869
Lodigiani, C., Iapichino, G., Carenzo, L. et al. (2020). Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Milan, Italy. Thromb Res. 2020;191:9-14. doi:10.1016/j.thromres.2020.04.024
Longchamp, A., Longchamp, J., Manzocchi-Besson S. et al. (2020).Venous thromboembolism in critically Ill patients with COVID-19: Results of a screening study for deep vein thrombosis. Res Pract Thromb Haemost. 2020;4(5):842-847. Published 2020 Jun 30. doi:10.1002/rth2.12376
Madjid, M., Safavi-Naeini P., Solomon, S. D. & Vardeny, O. (2020). Potential Effects of Coronaviruses on the Cardiovascular System: A Review. JAMA Cardiol. 2020 Jul 1;5(7):831-840. doi: 10.1001/jamacardio.2020.1286. PMID: 32219363.
Middeldorp, S., Coppens, M. & Van Haaps, T.F. et al. (2020). Incidence of venous thromboembolism in hospitalized patients with COVID-19. J Thromb Haemost. 2020;18(8):1995-2002. doi:10.1111/jth.14888
Moll, M., Zon, R.L., Sylvester, K.W. et al. (2020). VTE in ICU Patients With COVID-19. Chest. 2020;158(5):2130-2135. doi:10.1016/j.chest.2020.07.031
Opas. (2020). Folha informativa sobre COVID-19. <https://www.paho.org/pt/covid19>.
Páramo, J. A. (2020). Coagulopatia e trombose: semelhanças e diferenças entre coronavírus patogênicos. Anales Sis San Navarra, Pamplona, v. 43, n. 2 P. 245-249.
Passos, H. D. et al. (2020). Infecção pelo SARS-Cov-2 e Tromboembolismo Pulmonar – Comportamento Pró - Trombótico da COVID-19. Arquivos Brasileiros de Cardiologia [online]. 2020, v. 115, n. 1. 142-145. Epub 07 Ago 2020. ISSN 1678-4170. https://doi.org/10.36660/abc.20200427.
Perico, L., Benigni, A., Casiraghi, F., Renia, L. & Remuzzi, G. (2021). Immunity, endothelial injury and complement-induced coagulopathy in COVID-19. Nat Rev Nephrol. 2021 Jan;17(1):46-64. doi: 10.1038/s41581-020-00357-4. Epub 2020 Oct 19. PMID: 33077917; PMCID: PMC7570423.
Poissy, J, Goutay, J, Caplan, M. et al. (2020).Pulmonary embolism in COVID-19 patients: awareness of an increased prevalence. Circulation, (2020), https://doi.org/10. 1161/ circulationaha.120.047430.
Prodanov, C. C. & Freitas, E. C. de. (2013). Metodologia do trabalho científico: métodos e técnicas da pesquisa e do trabalho acadêmico. 2. ed. Novo Hamburgo: Feevale.
Rossi, F. H. (2020). Tromboembolismo venoso em pacientes COVID-19. Jornal Vascular Brasileiro [online]. 2020, v. 19. e20200107. Epub 16 Out 2020. ISSN 1677-7301. https://doi.org/10.1590/1677-5449.200107.
San Norberto, E. M. et al. (2020).Tratamento da doença tromboembólica venosa na era COVID-19. Recomendações do capítulo espanhol de Flebologia e Linfologia da SEACV. Angiologia, Madrid, v. 72, n. 4, pág. 186-197, agosto de 2020. <http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0003-31702020000400003&lng=es&nrm=iso>.
Siddiq, H. K, Libby, P. & Ridker, P.M. (2021). COVID-19 - A vascular disease. Trends Cardiovasc Med. 2021 Jan;31(1):1-5. doi: 10.1016/j.tcm.2020.10.005. Epub 2020 Oct 14. PMID: 33068723; PMCID: PMC7556303.
Tang, N., Bai, H., Chen, X., Gong, J.; Li, D. & Sun, Z. (2020). Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy. J Thromb Haemost. 2020 May;18(5):1094-1099. doi: 10.1111/jth.14817. Epub 2020 Apr 27. PMID: 32220112.
Thomas W, Varley J, Johnston A, et al. (2020). Thrombotic complications of patients admitted to intensive care with COVID-19 at a teaching hospital in the United Kingdom. Thromb Res. 2020;191:76-77. doi:10.1016/j.thromres.2020.04.028
Trimaille, A., Curtiaud, A., Marchandot, B. et al. (2020). Venous thromboembolism in non-critically ill patients with COVID-19 infection. Thromb Res. 2020;193:166-169. doi:10.1016/j.thromres.2020.07.033
Vaduganathan, M., Vardeny, O., Michel, T., Mcmurray, J. J. V., Pfefer, M. A. & Solomon, S.D. (2020). Renin-angiotensin-aldosterone system inhibitors in patients with Covid-19. Doi: DOI: 10.1056/NEJMsr2005760. N Engl J Med. 2020;382(17):1653–9
Wichmann, D., Sperhake, J. P., Lutgehetmann, M. et al. (2020). Autopsy Findings and Venous Thromboembolism in Patients With COVID-19: A Prospective Cohort Study. Ann Intern Med. 2020;173(4):268-277. doi:10.7326/M20-2003
Zhang, L., Zhang, D., Feng, X. et al. (2020). Deep Vein Thrombosis in Hospitalized Patients With COVID-19 in Wuhan, China. Published 2020 May. https://doi.org/10.1161/CIRCULATIONAHA.120.046702
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