Efficacy and risks of the use of psychotropics drugs in children and adolescents with depression disorders: a literature review

Authors

DOI:

https://doi.org/10.33448/rsd-v11i14.36284

Keywords:

Antidepressants; Children; Teenagers; Risk factors and suicide.

Abstract

The transition from childhood to adolescence is a period of life characterized by hormonal and physiological changes. In this phase, there are also several social interactions that change according to the environment, imposing responsibilities and a desire for new cycles. These demands make people vulnerable and insecure to certain feelings, generating mood disorders that can progress to major depression disorder. Objective: to evaluate the efficacy and risks of psychotropic drugs prescribed to children and adolescents with depression disorders. Method: This is a bibliographic review of scientific articles of the descriptive-quantitative type, searched online, on Google Scholar platforms, Virtual Health Library - VHL (Medline, IBECS, LILACS), Portal Periodicals CAPES and SciELO and prepared from 1987 to 2021. The search used the descriptors, antidepressants, psychotropic drugs, adverse effects, depressed children and adolescents, in Portuguese, English and Spanish. Result: the same psychotropic drug is used in several other mental disorders, such as bipolar disorder and anxiety. Drugs that demonstrated significant efficacy were Serotonin Reuptake Inhibitors (SSRIs) such as paroxetine, sertraline and fluoxetine. Final Considerations: the psychotropic drugs used to treat depression in children and adolescents, although they are effective in some cases, nevertheless cause several adverse effects. The use of these drugs should not be carried out indiscriminately so that their risks do not outweigh their benefits, and it is essential to assess the causes of childhood depression and the clinical follow-up of patients by a multidisciplinary team.

References

Abasse, M. L. F., de Oliveira, R. C., Silva, T. C., de Souza, E. R., (2009). Análise epidemiológica da morbimortalidade por suicídio entre adolescentes em Minas Gerais, Brasil. https://www.scielo.br/j/csc/a/Hpb78xC8wq5kdVvmW4PrR4k/?lang=pt

Abramovitch, S., & de Aragão, L. (2014). Depressão na infância e adolescência. Revista Hospital Universitário Pedro Ernesto. https://www.e-publicacoes.uerj.br/index.php/revistahupe/article/view/8851/6730

Asbahr, F. R., et al. (2004). Transtornos ansiosos da infância e no adolescentes: aspectos clínicos e neurobiológicos. https://www.scielo.br/j/jped/a/pqwnF9Bd83TVpKVYWNDwY4C/?lang=pt

Assef, I. L., Macías, M. S., Bañuelos, R. E. A., Sánchez, P., Pérez, G. G., Castañeda, V. L., & Hernández, C. G. (2010) Farmacoepidemiologia de psicofármacos empleados em La práctica pediátrica em el Servicio de psiquiatria Infantil del Hospital General de Durango, Mexico. Boletim Médico Hospital Infantil do México, 67(1). http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S1665-11462010000100004&lang=pt.

Barboza, M. P., Medeiros, D. B. S., Silva, N. M. S., & Souza, P. G. V. D. (2021). O uso de antidepressivos na adolescência e sua automedicação. Pesquisa, Sociedade e Desenvolvimento, 10(15). https://rsdjournal.org/index.php/rsd/article/view/22995

Biazus, C. B., & Ramires, V. R. R. (2012) Depressão na adolescência: um problema dos vínculos. https://www.scielo.br/j/pe/a/RSkXKnYD4frXYKQrmzGdGMn/?lang=pt

Brasil, H. H. A., et al., (2001). Princípios gerais no emprego de psicofármacos. https://www.scielo.br/j/rbp/a/FSnWzWxtbnqcbyswTNwgkdP/?lang=pt#

Caballero, C. M. A., Colas, V. M. C., Román, M. B., Maso, Y. S., & Vals, Y. F. (2017). Principales factores de riesgo relacionados com el intento suicida enun grupo de adolescentes. MEDISAN, 21(2), 154-160. http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1029-30192017000200004&lng=es&tlng=es.

Caregnato & Mutti (2006), Pesquisa qualitativa> análise de discurso versus análise de conteúdo. Texto Contexto Enferm, Florianópolis.

Carvallo, A., Holt, K. G., Hejazi, M. S., Richards, G. E., & Meyer, W. J. (1987). Melatonin Orcadian Rhythm in Chilhood Depression, 26(3), 395-399. Journal of the American Academy of Child and Adolescent Psychiatry. https://www.jaacap.org/article/S0890-8567(09)65697-5/pdf

Cheung, A. H., Emslie, G. J., & Mayes, T. L. (2005). Review of the efficacy and safety of antidepressants in youth depression. 46(7):735-54. https://pubmed.ncbi.nlm.nih.gov/15972068/

Cheung, A. H., Zuckerbrot, R. A., Jensen, P. S., Laraque, D., & Stein, R. E. K. (2017). Guidelines for Adolescents in Primary Care (GLAD-PC): Part II. Treatment and Ongoing Managment. https://pubmed.ncbi.nlm.nih.gov/29483201/

Hetrick, S. E., McKenzie, J. E., Bailey, A. P., Sharma, V., Moller, C. L., Badcock, P. B., Cox, G. R., Merry, S. N., & Meader, N. (2021). New generation antidepressants for depression in children and adolescents: a network meta-analysis. https://pubmed.ncbi.nlm.nih.gov/34029378/

Léon, E. A. (2021). Mania and hipomania induced by antidepressants in children and adolescents. Bibliographic review. https://pesquisa.bvsalud.org/portal/resource/pt/mdl-34783792?lang=en.

Machado-Duque, M. E., Echeverri-Chabur, J. E., & Machado-Alba, J. E., (2017). Utilización de medicamentos antidepresivo sem población adolescente de Colombia: unestudio tipo prescripción-indicación, 15(3): 387-369. https://pesquisa.bvsalud.org/portal/resource/pt/biblio-1042724

Maia, J. D. de M., & Dolabela, M. F. (2022). O uso de aromaterapia na depressão. Pesquisa, Sociedade e Desenvolvimento, 11(10), e1001111032367. https://doi.org/10.33448/rsd-v11i10.32367

Maia, C. R. M., & Rohde, L. A. (2007). Psicofármacos para o tratamento de transtornos de ansiedade em crianças e adolescentes: uma revisão sistemática. https://www.scielo.br/j/rbp/a/9nVp7HJYGQrSdn73vjB4FLB/?lang=pt

Manual diagnóstico e estatístico de transtornos mentais: DSM-V. Porto Alegre: Artmed, 2014. (p154-190)

Mesquita, M. E., Finazzi, M. E., Gonçalves, B., Fu-l, Lee., Duarte, L. L., Lopes, J. R., Del-Porto, J. A., & Menna-Barreto, L. (2016). Ritmo de atividade e repouso em adolescentes deprimidos durante terapia: estudo de caso. https://www.scielo.br/j/trends/a/tfwBNWQvyCWm9ym7LgGLYRF/?lang=en#

Oliveira, W. R., Freitas, D. L., Santiago, R. O., Campos, S. T. P., & de Morais, I. C. O. (2019). A utilização de antidepressivos na adolescência. Mostra Científica de Farmácia, 6(1). http://publicacoesacademicas.unicatolicaquixada.edu.br/index.php/mostracientificafarmacia/article/view/3519

Organização Pan-Americana de Saúde – Saúde mental dos Adolescentes. (2021). https://www.paho.org/pt/topicos/saude-mental-dos-adolescentes

Pinheiro, M. H. N. O., Moreira, M. G. O., Moreira, I. V. S., & Barros, K. B. N. T. (2019). Aumento do comportamento suicida em crianças e adolescentes com o uso de antidepressivos: revisão de literatura. 6(1). http://reservas.fcrs.edu.br/index.php/mostracientificafarmacia/article/view/3527http://reservas.fcrs.edu.br/index.php/mostracientificafarmacia/article/view/3527

Plöderl, M., & Hengartner, M. P., (2021). Suicidality and other severe psychiatric events with duloxetine: Re-analysis of safety data from a placebo-controlled trial for juvenile fibromyalgia. 32(3): 209-218. https://pesquisa.bvsalud.org/portal/resource/pt/mdl-34397423?lang=es.

Rocha, G. P., Batista, B. H., & Nunes, M. L. (2004). Orientações ao pediatra sobre o manejo das drogas psicoativas e antiepiléticas. https://www.scielo.br/j/jped/a/WkwF6F3YTTYkWWY7RL384gC/abstract/?lang=pt#top

Secretaria de Vigilância em Saúde, Ministério da Saúde, Boletim Epidemiológico (2021). Mortalidade por suicídio e notificações de lesões autoprovocadas no Brasil. https://www.gov.br/saude/pt-br/centrais-de-conteudo/publicacoes/boletins/boletins-epidemiologicos/edicoes/2021/boletim_epidemiologico_svs_33_final.pdf

Silva, K. A., Dallecrode, V. C. F., Galdino, K. C. S., Sá, L. de O., & Lemos, A. C. M. (2021). Eficácia da Arteterapia como tratamento complementar a depressão em idosos. Research, Society and Development, 10(7), e14010716411. https://doi.org/10.33448/rsd-v10i7.16411

Silva, J. J. F. e, & Costa, R. S. (2021). Integrative and complementary practices in the treatment of depression: integrative review. Research, Society and Development, 10(16), e168101623595. https://doi.org/10.33448/rsd-v10i16.23595

Souza, M. T., Silva, M. D., & Carvalho, R. (2010). Uma revisão integrativa: o que é e como fazer. https://doi.org/10.1590/S1679-45082010RW1134

Souza, F. G. M., et al. (1999). Tratamento de depressão. https://www.scielo.br/j/rbp/a/t79BpmNTfSCMGW8KPsKwXMj/abstract/?lang=pt

Teicher, M. H., Glod, C., Harper, D., Magnus, E., Brasher, C., Wren, F., & Pahlavan, K. (1993). Locomotor Activity in Depressed Chidren and Adolescents: I Circadian Dysregulation, volume 32, issue 4, p760-769. Journal of the American Academy of Child and Adolescent Psychiatry. https://www.jaacap.org/article/S0890-8567(09)64865-6/pdf

Toniazzo, B. D., Gomes, C. G., & Rocha, G. P. (2014) Risco de suicídio infantil: quando os sonhos terminam. 35(6). https://pesquisa.bvsalud.org/portal/resource/pt/biblio-882822

World Health Organization. (2021). Depressíon. https://www.who.int/es/news-room/fact-sheets/detail/depression

Zhaoxia, Y., Baomei, L., Xehua, Y., & Xiaoying, Z. (2021). Systematic review and meta-analysis of the effects of group painting therapy on the negative emotions of depressed adolescents patients. https://pesquisa.bvsalud.org/portal/resource/pt/mdl-34763436?lang=es

Published

27/10/2022

How to Cite

BOTERO, B.; FIGUEIREDO, E. F. G. .; COSTA, J. E. B. da .; MAGALHÃES, M. N. de O. .; ALMEIDA , P. H. F. de .; MARTIM, S. R. .; SILVA, Y. T. P. da . Efficacy and risks of the use of psychotropics drugs in children and adolescents with depression disorders: a literature review. Research, Society and Development, [S. l.], v. 11, n. 14, p. e304111436284, 2022. DOI: 10.33448/rsd-v11i14.36284. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/36284. Acesso em: 23 nov. 2024.

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Section

Health Sciences