Tuberculosis in children: challenges in diagnosis
DOI:
https://doi.org/10.33448/rsd-v11i15.37287Keywords:
Child; Tuberculosis; Diagnosis.Abstract
Tuberculosis (TB), despite the existence of a vaccine and effective treatments, is still a major public health challenge and children are significantly affected by not having the disease previously identified. Therefore, this study aimed to describe the existing limitations in diagnostic tests for TB in children, according to national and international literature. This is an integrative review that was carried out using the Lilacs, PubMed, Scopus, Embase and Web of Science databases with indexed descriptors and their respective synonyms in DeCS, Mesh and Emtree, based on the guiding question "What are the limitations existing in diagnostic tests for the detection of TB in children that make it difficult to prove it?”. Titles and abstracts of materials that met the following inclusion criteria were analyzed: full articles, published in Portuguese, English and Spanish in the last 10 years, excluding those that were not characterized as scientific and duplicate articles. Twenty-six articles were selected, which reinforced the importance of the association between the tuberculin test, epidemiological, radiological factors and clinical picture for the diagnostic elucidation of TB that are usually performed by specialized services, considering the complexity of diagnostic elucidation and follow-up of these cases, since that underdiagnosis can interfere with quality of life and adequate management.
References
Anleu I. D. C., & Serratos J. R. V. (2012) Childhood tuberculosis. How to diagnose it? Arch Argent Pediatr, 110(2), 144-151.
Atehortúa-Muñoz, S., Cardona-Moreno, A., Niño-Quiroga, L., Contreras-Ortiz, J., & Arango-Ferreira, C. (2020). Combined use of gastric aspirate and induced sputum increases the microbiological diagnosis of Tuberculosis in children. Journal of Pediatric Infectious Diseases, 15(5), 217-222.
Atherton, R. R., Cresswell, F. V., Ellis, J., Kitaka, S. B., & Boulware, D. R. (2019). Xpert MTB/RIF Ultra for Tuberculosis Testing in Children: A Mini-Review and Commentary. Frontiers in Pediatrics, 7, 34.
Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. (2019). Departamento de Vigilância Epidemiológica. Manual de recomendações para o controle da tuberculose no Brasil. Brasília: Ministério da Saúde.
Brasil. Ministério da Saúde. (2022). Boletim Epidemiológico de Tuberculose. Número Especial. Brasília.
Cano A. P. G., Romaneli M. T. N., Pereira R. M., & Tresoldi A. T. (2017). Tuberculose em pacientes pediátricos: como tem sido feito o diagnóstico? Rev. Paul. Pediátrica, 35(2), 165-170.
Chen S. C., Chen K. L., Chen K. H., Chien S. T., & Chen K. T. (2013). Updated diagnosis and treatment of childhood tuberculosis. World Journal of Pediatrics, 9(1), 9-16.
Chiang S. S., Roche S., Contreras C., Alarcon V., Del Castillo H., Becerra M. C., & Lecca L. (2015). Barriers to the diagnosis of childhood tuberculosis: a qualitative study. International Journal of Tuberculosis and Lung Disease, 19(10), 1144-1152.
Chiappini, E., Lo Vecchio, A., Garazzino, S., Marseglia, G. L., Bernardi, F., Castagnola, E., Tomà, P., Cirillo, D., Russo, C., Gabiano, C., Ciofi, D., Losurdo, G., Bocchino, M., Tortoli, E., Tadolini, M., Villani, A., Guarino, A., & Esposito, S. (2016). Recommendations for the diagnosis of pediatric tuberculosis. Eur J Clin Microbiol Infect Dis, 35, 1-18.
Coelho Filho, J. C., Caribé, M. A., Caldas, S. C. C., & Martins Netto, E. (2011). A tuberculose na infância e na adolescência é difícil de diagnosticar? Jornal Brasileiro de Pneumologia, 37(3), 288-293.
Djouahra, A. M., Ifticene, M., Yala, D., & Boulahbal, F. (2017). The difficulties of childhood tuberculosis diagnosis. Biomedical and Biotechnology Research Journal, 1(1), 55-58.
Elhassan, M. M., Elmekki, M. A., Osman, A. L., & Hamid, M. E. (2016). Challenges in diagnosing tuberculosis in children: a comparative study from Sudan. International Journal of Infectious Diseases, 43, 25-29.
Graham, S. M. (2011). The use of Diagnostic Systems for Tuberculosis in Children. Indian Journal of Pediatrics, 78(3), 334-339.
Gutierrez-Gonzalez, L. H., Juarez, E., Carranza, C., Carreto-Binaghi, L. E., Alejandre, A., Cabello-Gutierrez, C., & Gonzalez, Y. (2021). Immunological Aspects of Diagnosis and Management of Childhood Tuberculosis. Infection and Drug Resistance, 14, 929-946.
Khan, K. S., Kunz, R., Kleijnen, J., & Antes, G. (2003). Systematic Reviews to Support Evidence-Based Medicina: How to review and apply findings of healthcare research. Royal Society of Medicine Press Ltd., Londres, 2003.
Laniado-Laborin, R. (2015). Alternativas Actuales para la Confirmación Diagnóstica de Tuberculosis en Pacientes Pediátricos. Neumologia Pediátrica, 10(4), 174-178.
Mendes, E. V. (2015). As redes de atenção à saúde. (2ª Ed.): Organização Panamericana de Saúde.
Moher, D., Liberati, A., Tetzlaff, J., & Altman, D. G. (2009). Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement. PLoS Medicine, 6, 7.
Nicol, M. P., & Zar, H. J. (2020). Advances in the Diagnosis of Pulmonary Tuberculosis in Children. Pediatr Respir Rev., 36, 52-56.
Ouzzani, M., Hammady, H., Fedorowicz, Z., & Elmagarmid, A. (2016). Rayyan — a web and mobile app for systematic reviews. Systematic Reviews, 5, 210.
Perez-Porcuna, T. M., Ascaso, C., Ogusku, M. M., Abellana, R., Malheiro, A., Quinco P., Antunes, I., Monte, R., Tavares, M., Garrido, M., Buhrer-Sékula, S., & Martinez-Espinosa, E. (2012). Evaluation of New Strategies for the Diagnosis of Tuberculosis Among Pediatric Contacts of Tuberculosis Patients. The Pediatric Infectious Disease Journal, 31(9), 141-146.
Perez-Velez, C. M., Roya-Pabon, C. L., & Marais, B. J. (2017). A systematic approach to diagnosing intra-thoracic tuberculosis in children. Journal of Infection, 74, 74-83.
Pierre-Louis, M. H., Rouzier, V., Rivera, V., Systrom, H. K., Julma, P., Jean, E., Francois, L. C., Pape, J. W., Ocheretina, O., & Wright, P. F. (2021). Diagnosis of Tuberculosis Using Gastric Aspirates in Pediatric Patients in Haiti. Journal of the Pediatric Infectious Diseases Society, 10(1), 22-26.
Rahman, N., Pedersen, K. K., Rosenfeldt, V., & Johansen I. S. (2012). Challenges in diagnosing tuberculosis in children. Danish Medical Journal, 59, 7.
Reuter, A., Hughes, J., Furin, J. (2019). Challenges and controversies in childhood tuberculosis. Lancet, 394(10202), 967-978.
Rossoni, A. M. O., Rossoni, M. D., & Rodrigues, C. O. (2013). Critérios de Pontuação para Diagnóstico de Tuberculose em Crianças. Pulmão RJ, 22(3), 65-69.
Roya-Pabon, C. L., & Perez-Velez, C. M. (2016). Tuberculosis exposure, infection and disease in children: a systematic diagnostic approach. Pneumonia, 8, 23.
Sant’Anna, C. C. (2012). Diagnóstico da Tuberculose na Infância e na Adolescência. Pulmão RJ, 21(1), 60-64.
Shingadia, D. (2012). The diagnosis of Tuberculosis. The Pediatric Infectious Disease Journal, 31(3), 302-305.
Silva D. R., Rabahi M. F., Sant’Anna C. C., Silva-Junior J. L. R., Capone D., Bombarda S., Mirando S. S., Rocha J. L., Dalcolmo M. M. P., Rick M. F., Santos A. P., Dalcin P. T. R., Galvão T. S., & Mello F. C. Q. (2021). Consenso sobre o diagnóstico da tuberculose da Sociedade Brasileira de Pneumologia e Tisiologia. Jornal Brasileiro de Pneumologia, 47(2), 1-13.
Sociedade Brasileira de Pediatria (SBP). Tratado de Pediatria: 2 volumes. (4a ed.), Manole, 2017.
Souza, M. T., Silva, M. D. & Carvalho, R. (2010). Revisão integrativa: o que é e como fazer. Einstein, 8(1), 102-106.
Triasih, R. (2015). Newer diagnostic tests for pulmonary tuberculosis in children. Indian Journal of Pediatrics, 82(9), 827-832.
Venturini, E., Remaschi, G., Berti, E., Montagnani, C., Galli, L., Martino, M., & Chiappini, E. (2015). What steps do we need to take to improve diagnosis of tuberculosis in children. Expert Review of Anti-infective Therapy, 13(7), 1-16.
World Health Organization. Global tuberculosis report 2020. Genebra. WHO; 2020.
Xavier, J. N., Francisco, A. N. A., & Orfão, N. H. (2021). Análise espacial da tuberculose infantil em um município da Amazônia Brasileira. Revista Científica da Faculdade Unimed, 2, 19-35.
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