Organ Dysfunctions due to Covid-19
DOI:
https://doi.org/10.33448/rsd-v12i9.43155Keywords:
SARS-CoV-2; Covid-19; Organic dysfunctions.Abstract
The aim of this study is to conduct a narrative review of the literature to better understand the extensive pathological effect of Covid-19 on vital organs and to point out new updates on the subject. The world has been impacted by the coronavirus disease 2019 pandemic, a severe acute respiratory syndrome caused by the SARS-CoV-2 coronavirus. Organic dysfunctions present as alterations or loss of the normal functions of vital organs and systems of the human body, which can lead to the failure of multiple organs. Although Covid-19 presents primarily as a respiratory tract infection transmitted by air droplets, growing data suggest multi-organ involvement. SARS-CoV-2 has as its mechanism of infection the binding of the viral protein to the ECA2 receptor, which facilitates the spread of the virus through the vascular system. Accumulated evidence indicates that patients who have developed Covid-19 may present in addition to airway compromise, neurological, cardiac, renal, metabolic and intestinal symptoms accompanied by a deficient and ineffective immune response, however, new searches are crucial to better understand its etiology.
References
Akter, F., Mannan, A., Mehedi, H. H., Rob, M. A., Ahmed, S., Salauddin, A., Hossain, M. S., & Hasan, M. M. (2020). Clinical characteristics and short term outcomes after recovery from COVID-19 in patients with and without diabetes in Bangladesh. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 14(06), 2031-2038. doi.org/10.1016/j.dsx.2020.10.016
Al-Ramadan, A., Rabab’h, O., Shah, J., & Gharaibeh, A. (2021). Acute and Post-Acute Neurological Complications of COVID-19. Neurol. Int, 13, 102-119. doi.org/10.3390/neurolint13010010
Anghebem, M. I., Rego, F. G. d. M., & Picheth, G. (2020). COVID-19 e Diabetes: a relação entre duas pandemias distintas. rbac, 52(2), 154-159. doi.org/10.21877/2448-3877.20200001
Augustine, R., S, A., Nayeem, A., Salam, S. A., Augustine, P., Dan, P., & Hasan, A. (2022). Increased complications of COVID-19 in people with cardiovascular disease: Role of the renin–angiotensin-aldosterone system (RAAS) dysregulation. Chemico-Biological Interactions, 351. doi.org/10.1016/j.cbi.2021.109738
Batlle, D., Soler, M., Sparks, M., Hiremath, S., South, A., Welling, P., & Swaminathan, S. (2020). Acute Kidney Injury in COVID-19: Emerging Evidence of a Distinct Pathophysiology. J Am Soc Nephrol, 31(07), 1380-1383. doi.org/10.1681/ASN.2020040419
Batista, L.S. & Kumada, K. M. O. (2021). Análise metodológica sobre as diferentes configurações da pesquisa bibliográfica. Revista Brasileira de Iniciação Científica. 8(021029), 1-17.
Brann, D. H., Tsukahara, T., Weinreb, C., Lipovsek, M., Gong, B., Chance, R., Macaulay, I. C., & Datta, S. R. (2020). Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system sugests mechanisms underlying COVID-19–associated anosmia. Sci Adv, 6(31). doi.org/10.1126/sciadv.abc5801
Brem, F., Chaymae, M., Rasras, H., Merbouh, M., Bouazzaoui, M., Bkiyar, H., Abda, N., Zakaria, B., Ismaili, N., Housni, B., & Ouafi, N. (2022). Acute Myocardial Injury Assessed by High Sensitive Cardiac Troponin Predicting Severe Outcomes and Death in Hospitalized Patients with COVID-19 Infection. Clinical and Applied Thrombosis/Hemostasis, 18. doi.org/10.1177/10760296221090227
Chen, Y., Shao, S., Hsu, C., Wu, I., Hung, M., & Chen, Y. (2020). Incidence of acute kidney injury in COVID-19 infection: a systematic review and metaanalysis. Critical Care, 24(346). doi.org/10.1186/s13054-020-03009-y
Ebinger, J. E., Achamallah, N., Ji, H., Claggett, B. L., Sun, N., Botting, P., & Cheng, S. (2020). Pre-existing traits associated with Covid-19 illness severity. PLOS ONE, 15(7). doi.org/ 10.1371/journal.pone.0236240
Fignani, D., Licata, G., Brusco, N., Nigi, L., Grieco, G. E., Marselli, L., Overbergh, L., Gysemans, C., Colli, M. L., & Marchetti, P. (2020). SARS-CoV-2 Receptor Angiotensin I-Converting Enzyme Type 2 (ACE2) Is Expressed in Human Pancreatic b-Cells and in the Human Pancreas Microvasculature. Frontiers in endocrinology, 13(11). doi.org/10.3389/fendo.2020.596898
Garces, T. S., Sousa, G. J. B., Cestari, V. R. F., Florêncio, R. S., Damasceno, L. L. V., Pereira, M. L. D., & Moreira, T. M. M. (2022). Diabetes como um fator associado ao óbito hospitalar por COVID-19 no Brasil, 2020. Revista do SUS, 31(1). doi.org/10.1590/S1679-49742022000100021
Hingorani, K. S., Bhadola, S., & Cervantes-Arslanian, A. M. (2022). COVID-19 and the brain. Trends in Cardiovascular Medicine, 32, 323-330. doi.org/10.1016/j.tcm.2022.04.004
Hung, Y., Lin, W. Y., Chao, T. F., Liao, J. N., Lin, Y. J., Lin, W. S., Chen, Y. J., & Chen, S. A. (2020). Management of Atrial Fibrillation in COVID-19 Pandemic. Circulation Journal, 84, 1679-1685. doi.org/10.1253/circj.CJ-20-0566
Isnard, P., Vergnaud, P., Garbay, S., Jamme, M., Eloudzeri, M., Karras, A., Anglicheau, D., Galantine, V., Eddine, A. J., Gosset, C., & Rabant, M. (2023). A specific molecular signature in SARS-CoV-2 infected kidney biopsies. JCI Insight, 8(5). doi.org/10.1172/jci.insight.165192
Jewell, P., Bramham, K., Galloway, J., Post, F., Norton, S., Teo, J., Fisher, R., & Lioudaki, E. (2021). COVID-19 related acute kidney injury; incidence, risk factors and outcomes in a large UK cohort. BMC Nephrol, 22(359). doi.org/10.1186/s12882-021-02557-x
Jin, B., Singh, R., Ha, S., Zogg, H., Park, P., & Ro, S. (2021). Pathophysiological mechanisms underlying gastrointestinal symptoms in patients with COVID-19. World J Gastroenterol, 27(19), 2341-2352. doi.org/10.3748/wjg.v27.i19.2341
Kozlik, M., Btahuszewska, A., & Kazmierski, M. (2022). Cardiovascular System during SARS-CoV-2 Infection. International Journal of Environmental Research and Public Health, 19, 1184. doi.org/10.3390/ ijerph19031184
Lowe, R., Ferrari, M., Mohi, M., Jackson, A., Beecham, R., Veighey, K., Cusack, R., Richardson, D., Grocott, M., Levett, D., & Dushianthan, A. (2021). Clinical characteristics and outcome of criticallyill COVID-19 patients with acute kidney injury: a single centre cohort study. BMC Nephrology, 22(92). doi.org/10.1186/s12882-021-02296-z
Mehrabani, M. M., Karvandi, M. S., Maafi, P., & Doroudian, M. (2022). Neurological complications associated with Covid‐19; molecular mechanisms and therapeutic approaches. Rev Med Virol, 2334. doi.org/10.1002/rmv.2334
Nadim, M., Forni, L., Mehta, R., Connor, M., Liu, K., Ostermann, M., Rimmelé, T., Zarbock, A., Bell, S., & Kellum, J. (2020). COVID-19 associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup. Nature Reviews Nephrology, 16(12), 747-764. doi.org/10.1038/s41581-020-00356-5
Nalbandian, A., Sehgal, K., Gupta, A., Madhavan, M., McGroder, C., Stevens, J., Cook, J., & Wan, E. (2021). Post-acute COVID-19 syndrome. Nature Medicine, 27, 601-6015. doi.org/10.1038/s41591-021-01283-z
Newcombe, V., Dangayach, N., & Sonneville, R. (2021). Neurological complications of COVID 19. Intensive Care Med, 47, 1021-1023. doi.org/10.1007/s00134-021-06439-6
Nishiga, M., Wang, D. W., Han, Y., Lewis, D. B., & Wu, J. C. (2020). COVID-19 and cardiovascular disease: from basic mechanisms to clinical perspectives. Nature Revlews Cardiology, 17, 543-558. doi.org/10.1038/ s41569-020-0413-9
Peiris, S., Ordunez, P., Dipette, D., Padwal, R., Ambrosi, P., Toledo, J., Stanford, V., Lisboa, T., Aldighieri, S., & Reveiz, L. (2022). Cardiac Manifestations in Patients with COVID-19: A Scoping Review. Global Heart, 17(1). doi.org/10.5334/ gh.1037
Rathmann, W., Kuss, O., & Kostev, K. (2022). Incidence of newly diagnosed diabetes after Covid-19. Diabetologia, 65(6), 949-954. doi.org/10.1007/s00125-022-05670-0
Ruiz, V. J. C., Montes, R. I., Puerta, J. M. P. J. M., Ruiza, C., & Rodrígueza, L. M. (2020). SARS-CoV-2 infection: The role of cytokines in COVID-19 disease. Cytokine and Growth Factor Reviews, 54, 62-75. doi.org/10.1016/j.cytogfr.2020.06.001
Sabaghian, T., Kharazmi, A., Ansari, A., Omidi, F., Kazemi, S., Hajikhani, B., Harami, R., Tajbakhsh, A., Omidi, S., Haddadi, S., & Mirsaeidi, M. (2022). COVID-19 and Acute Kidney Injury: A Systematic Review. Frontiers inMedicine, 9. doi.org/10.3389/fmed.2022.705908
Sathish, T., Kapoor, N., Cao, Y., Tapp, R. J., & Zimmet, P. (2020). Proportion of newly diagnosed diabetes in COVID-19 patients: A systematic review and meta-analysis. Wiley, 23(3), 870-874. doi.org/10.1111/dom.14269
Sathisha, T., Tappb, R. J., Cooperd, M. E., & Zimmetd, P. (2021). Potential metabolic and inflammatory pathways between COVID-19 and new-onset diabetes. Diabetes & Metabolism, 47(2). doi.org/10.1016/j.diabet.2020.10.002
Shimohata, T. (2022). Neuro-COVID- 19. Clin Exp Neuroimmunol, 13, 17-23. doi.org/10.1111/cen3.12676
Shetty, A., Tawhari, I., Boueri, L., Seif, N., Alahmadi, A., Gargiulo, R., Aggarwal, V., Usman, I., Kisselev, S., & Quaggin, S. (2021). COVID-19 – Associated Glomerular Disease. J Am Soc Nephrol, 32(01), 33-40. doi.org/10.1681/ASN.2020060804
Siddiq, M., Chan, A., Miorin, L., Yadaw, A., Beaumont, K., Kehrer, T., Cupic, A., & Iyengara, R. (2021). Functional Effects of Cardiomyocyte Injury in COVID-19. Journal of Virology, 96(2). doi.org/10.1128/JVI.01063-21
Sousa, J. R. & Santos, S. C. M. (2020). Análise do conteúdo em pesquisa qualitativa. Revista Pesquisa e Debate em Educação. 10(2), 1396-1416. doi.org/10.34019/2237-9444.2020.v10.31559.
Tanacli, R., Doeblin, P., Götze, C., Zieschang, V., Faragli, A., Stehning, C., Korosoglou, G., Erley, J., & Kelle, S. (2021). COVID-19 vs. Classical Myocarditis Associated Myocardial Injury Evaluated by Cardiac Magnetic Resonance and Endomyocardial Biopsy. Frontiers in Cardiovascular Medicine, 8. doi.org/10.3389/fcvm.2021.737257
Tiwari, N. R., Phatak, S., Sharma, V. R., & Agarwal, S. K. (2021). COVID-19 and thrombotic microangiopathies. Thrombosis Research, 202, 191-198. doi.org/10.1016/j.thromres.2021.04.012
Wool, G. D., & Miller, J. L. (2020). The Impact of COVID-19 Disease on Platelets and Coagulation. Pathobiology, 88(1), 15-27. doi.org/10.1159/000512007
Wu, X., Jing, H., Wang, C., Wang, Y., Zuo, N., Jiang, T., Novakovic, V., & Shi, J. (2022). Intestinal Damage in COVID-19: SARS-CoV-2 Infection and Intestinal Thrombosis. Fronteiras em Microbiologia, 13. doi.org/10.3389/fmicb.2022.860931
Yang, Y., Wei, Z., Xiong, C., & Qian, H. (2022). Direct mechanisms of SARS CoV 2 induced cardiomyocyte damage: an update. Virology, 19(1), 108. doi.org/10.1186/s12985-022-01833-y
Yarijani, Z. M., & Najafi, H. (2021). Kidney injury in COVID-19 patients, drug development and their renal complications: Review study. Biomedicine & Pharmacotherapy, 142. doi.org/10.1016/j.biopha.2021.111966
Ye, Q., Wang, B., Zhang, T,. Xu, J., & Shang, S. (2020). The mechanism and treatment of gastrointestinal symptoms in patients with COVID-19. American Journal of Physiology Gastrointest Liver Physiol, 319(2), 245-252. doi.org/10.1152/ajpgi.00148.2020
Xie, Y., Xu, E., Bowe, B., & Aly, Z. A. (2022). Long-term cardiovascular outcomes of COVID-19. Nature Medicine, 28, 583-590. doi.org/10.1038/s41591-022-01689-3
Zhang, H., Shao, B., Dang, Q., Chen, Z., Zhou, Q., Luo, H., Yuan, W., & Sun, Z. (2021) Pathogenesis and Mechanism of Gastrointestinal Infection With COVID-19. Frontiers in Immunology, 12. doi.org/10.3389/fimmu.2021.674074
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