The role of interleukin-1beta in the pathophysiology of periodontal disease: a literature review

Authors

DOI:

https://doi.org/10.33448/rsd-v9i7.4773

Keywords:

Inflammatory mediators; Cytokines; Periodontal disease; Interleukin-1beta.

Abstract

The bacteria involved in the gingival inflammatory process induce inflammatory responses characterized by the release of mediators, for example, interleukins, the cytokines involved in the course of development of periodontal disease are not yet fully established. The increase in the amount of interleukin-1beta (IL-1β) is correlated, in the periodontal lesion, with the progression from the stable lesion to the progressive lesion. The purpose of this literature review was to evaluate IL-1β and its influence on the development of periodontal disease. Initially, 860 articles from the following databases were evaluated in this literature review: Pubmed, Lilacs, Scielo, Web of Science, Embase and Cochrane. The search terms were: periodontal disease and IL-1β; periodontitis and IL-1β; oral health and IL-1β; gingivitis and IL-1β. With the adopted criteria, 28 articles were included in this literature review. The observed results showed that IL-1β is the one that most relates to the activity of the disease, since patients with periodontitis have a higher frequency of a genotype associated with increased production. These cytokines can be generated by immune cells, such as lymphocytes and monocytes in the medullary cavity or by other bone cells, particularly cells of the osteoblastic lineage. We conclude that IL-1β is directly related to the progression of periodontal disease, promoting the entry of inflammatory cells to the sites of infection and high levels of IL-1β are related to bleeding rates, probing depth and clinical level of insertion changed.

Author Biography

Caio Vinicius Gonçalves Roman-Torres, Universidade Santo Amaro, Departamento de Odontologia

Graduated in Dentistry from the University of Ribeirão Preto (1996), has a postgraduate degree in Endodontics from APCD - Ribeirão Preto (1997), specialization in Periodontics (1998), Master and Doctorate in Dentistry, sub-area Periodontics, from the University of Taubaté (2004 and 2009) and Post Doctorate in Periodontics from the Faculty of Dentistry, University of São Paulo (2019). Has participation in research in the Health area mainly in the development of applicable methodologies. Strong connection with scientific initiation projects encouraging the participation of students in the elaboration, development and presentation of research at scientific events. Professor of the Master's and Doctorate Program in Dentistry - UNISA / SP, Professor of the Undergraduate Dentistry Course - UNISA. He teaches in the disciplines of Periodontics, Oral Maxillofacial Surgery, Epidemiology, Higher Education Didactics and Public Health. Evaluator of Dentistry courses at INEP. Experience in Periodontics, Implantology and Epidemiology; acting mainly on the following themes: periodontal medicine, tissue surgical procedures, clinical trials, control of oral biofilm and oral factors that influence sports performanc

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Published

02/06/2020

How to Cite

FRÓES, A. C.; PASQUINELLI, F.; QUINTELA, M. de M.; PIMENTEL, A. C.; ROMAN-TORRES, C. V. G. The role of interleukin-1beta in the pathophysiology of periodontal disease: a literature review. Research, Society and Development, [S. l.], v. 9, n. 7, p. e674974773, 2020. DOI: 10.33448/rsd-v9i7.4773. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/4773. Acesso em: 23 nov. 2024.

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Vol. 9 No. 7

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Health Sciences

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