Aumento de la actividad anticoagulante de la warfarina y su suposible interacción con el extracto acuoso de la baya de goji (Lycium barbarum L.) en ratas Wistar
DOI:
https://doi.org/10.33448/rsd-v9i12.11070Palabras clave:
Asistencia sanitaria; Interacciones alimento-medicamento; Tiempo de protrombina; Tromboembolia venosa.Resumen
El consumo de la baya de goji (Lycium barbarum L.) ha despertado un interés a nivel mundial debido a sus excelentes propiedades nutricionales y funcionales, relacionadas con la disminución del riesgo de desarrollar enfermedades crónicas derivadas del estrés oxidativo, clasificándolo como un “super alimento”. Por lo tanto, el objetivo de este estudio ha sido evaluar los efectos del extracto acuoso de la baya de goji sobre parámetros hematológicos y bioquímicos en ratas Wistar tratadas con warfarina. La concentración de fenoles totales se determinó mediante el reactivo de Folin-Ciocalteau, mientras que la capacidad antioxidante fuera determinado mediante la prueba DPPH. Los animales fueron divididos en cuatro grupos experimentales: agua destilada (vehículo - control negativo); alimentado diariamente con el extracto (0,18 g.Kg-1); tratados diariamente con agua y warfarina (0,5 mg.Kg-1 - control positivo) y los tratados simultáneamente con el extracto y warfarina, a lo largo de siete días. Nuestros resultados mostraron una alta cantidad de polifenoles (6,19 ± 0,3 mg EAG.g-1) en el extracto acuoso al 10 % (m.v-1) y sugieren una actividad antioxidante considerable (IC50 1068 µg.mL-1). No hemos observado diferencias significativas entre los perfiles bioquímicos y hematológicos, o siquiera signos de toxicidad del extracto cuando se administra solamente el. Los datos provenientes del uso concomitante con warfarina son impresionantes y muestran un aumento significativo del tiempo de protrombina, con potencial de hemorragia. Conjuntamente, estas observaciones sugieren la propensión a una interacción clínicamente importante entre warfarina y Lycium barbarum L., lo que compromete la seguridad de este fármaco y nos aclara para la búsqueda de futuras investigaciones relacionadas con una comprensión más exhaustiva de los mecanismos moleculares implicados.
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Derechos de autor 2020 Gabriel Amoreli de Oliveira; Maxsuel Ananias Camilo; Luís Gustavo Marques; Carla Miguel de Oliveira; Sônia Aparecida Figueiredo; Leticia Barbosa Santos; Ramon Alves de Oliveira Paula; Fernanda Borges de Araújo Paula; Maria Rita Rodrigues; Stella Maris da Silveira Duarte
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