Corticosteroid therapy in patients with severe COVID-19

Thiago Costa de Araújo  Dantas; Andriny Cunha Apoliano  Gomes; Ikaro Peixoto Correia  Lima; Beatriz Bispo  Lucas; Mateus Rodrigues de  Aguiar; Taiza Carvalho de Holanda  Cavalcanti; Francisco Irochima  Pinheiro; Amália Cinthia Meneses  Rêgo; Irami Araújo-Filho

doi:10.33448/rsd-v10i1.12114

Autores/as

Thiago Costa de Araújo Dantas Universidade Potiguar https://orcid.org/0000-0002-1986-4883
Andriny Cunha Apoliano Gomes Universidade Potiguar https://orcid.org/0000-0003-3396-1572
Ikaro Peixoto Correia Lima Universidade Potiguar https://orcid.org/0000-0001-7599-2671
Beatriz Bispo Lucas Universidade Potiguar https://orcid.org/0000-0002-7819-4453
Mateus Rodrigues de Aguiar Universidade Potiguar https://orcid.org/0000-0001-7060-1205
Taiza Carvalho de Holanda Cavalcanti Universidade Potiguar https://orcid.org/0000-0003-4164-9802
Francisco Irochima Pinheiro Universidade Potiguar https://orcid.org/0000-0001-8879-3997
Amália Cinthia Meneses Rêgo Universidade Potiguar https://orcid.org/0000-0002-0575-3752
Irami Araújo-Filho Universidade Potiguar https://orcid.org/0000-0003-2471-7447

DOI:

https://doi.org/10.33448/rsd-v10i1.12114

Palabras clave:

Infecciones por coronavirus; COVID-19; SARS-CoV-2; Corticosteroides; Terapia; Terapéutica.

Resumen

El panorama mundial de diseminación del nuevo coronavirus SARS-CoV-2 es considerado una pandemia por la Organización Mundial de la Salud (OMS) con riesgo de complicaciones por el desequilibrio de las respuestas inmunes. El presente estudio evaluó si el uso de corticosteroides tiene eficacia científicamente probada en el tratamiento de pacientes con la forma grave de COVID-19. Se realizó una revisión transversal e integradora de la literatura de diciembre de 2019 a noviembre de 2020 tras consultar las bases de datos PubMed, Scopus, Embase, Web of Science y Google Scholar. Según los estudios analizados, se observaron resultados positivos de la corticoterapia en pacientes con SARS-CoV-2 en la forma grave de la enfermedad. Se concluyó que los esteroides no están indicados para la forma leve de COVID-19 a menos que existan otras comorbilidades, como enfermedad pulmonar obstructiva crónica (EPOC) o asma. La terapia con glucocorticoides es relevante en la forma grave de SARS-CoV-2, siendo beneficioso el tratamiento a corto plazo y las dosis bajas. Reduce la morbilidad, mortalidad y el tiempo de estancia en la UCI.

Citas

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Terapia con corticosteroides en pacientes con COVID-19 grave

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