Eficacia antibacteriana de las combinaciones de fármacos con hidróxido de calcio en la periodontitis apical: Una revisión sistemática
DOI:
https://doi.org/10.33448/rsd-v10i4.14593Palabras clave:
Hidróxido de calcio; Periodontitis apical; Eficacia antibacteriana; Revisión sistemática.Resumen
El objetivo de esta revisión sistemática fue comparar el rendimiento clínico del hidróxido de calcio (Ca(OH)2) como medicamento intracanal solo o combinado con otros agentes antimicrobianos. La pregunta de PICO fue "Es la eficacia antibacteriana de la pasta de hidróxido de calcio como medicamento intracanal combinado con otros fármacos mayor que la de la pasta de hidróxido de calcio sola en la periodontitis apical?" El estudio se realizó según las directrices PRISMA y está registrado en PROSPERO (CRD42020205741). Las búsquedas se realizaron en las bases de datos PubMed / MEDLINE, Web of Science y Cochrane sin restricciones de fecha de publicación. Inclusión: ensayos clínicos aleatorizados, estudios de intervención no aleatorizados, estudios que incluyan un mínimo de 10 pacientes, estudios que comparen el uso de Ca(OH)2 solo y en combinación con otros compuestos, estudios que evalúen dientes primarios y permanentes con periodontitis apical y estudios. incluidos los dientes no sometidos a retratamiento. Se utilizó la herramienta Cochrane de riesgo de sesgo para ensayos clínicos aleatorios (RoB 2.0) para evaluar la validez interna (riesgo de sesgo) de los estudios incluidos. Se recuperaron un total de 986 artículos y se seleccionaron 12 ensayos clínicos aleatorizados, con un total de 499 pacientes incluidos en los estudios. La eficacia del Ca(OH)2 más clorhexidina fue similar a la del Ca(OH)2 solo en ocho artículos, mientras que en tres estudios se informó un mejor efecto antibacteriano. La combinación con ciprofloxacina fue más eficaz que el uso de Ca(OH)2 solo en el único estudio que probó este antibiótico. En dientes con periodontitis apical asintomática, la eficacia de la combinación de agentes antimicrobianos con Ca(OH)2 fue similar a la del Ca(OH)2 solo.
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Derechos de autor 2021 Christianne Velozo; Cleidiel Aparecido Araújo Lemos ; Diana Santana de Albuquerque; Belmiro Cavalcante do Egito Vasconcelos; Sandra Lúcia Dantas Moraes ; Eduardo Piza Pellizzer
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