Prospección tecnológica de las actividades biológicas de Plectranthus amboinicus (Loureiro) Sprengel: una revisión integradora
DOI:
https://doi.org/10.33448/rsd-v10i5.14653Palabras clave:
Malvariço; Indian Borage; Plectranthus amboinicus (Loureiro) Sprengel; Prospección; Patentes.Resumen
Plectranthus amboinicus (Loureiro) Sprengel se conoce popularmente como malvariço o borraja india. Esta investigación realiza la prospección tecnológica de esta especie con énfasis en sus actividades biológicas. La investigación consistió en una revisión integradora de la literatura basada en información recopilada de bases de datos de patentes y bases de datos eletrónicas. Inicialmente se obtuvieron 3019 expedientes que, luego del proceso de cribado, selección y análisis dieron como resultado 55 artículos y 48 documentos de patente. Se encontró que el 77.08% (n=37) de los depósitos de patentes se refieren a la obtención o mejora del proceso y el 22.92% (n=11) al producto terminado con las siguientes indicaciones: cicatrización de heridas principalmente en pacientes diabéticos, seguida de tratamiento de artritis reumatoide, carcinomas hepatocelulares, cáncer de mama y melanoma, tratamiento del acne por P. acnes, S. aureus y P. aeruginosa, agente limpiador de la cavidad oral, tratamiento para la osteoporosis, composición nutracéutica para la lactancia y repelente de insectos. En las bases de datos de artículos científicos se seleccionaron 55 documentos, comprobando las siguientes acciones: antimicrobiano, antioxidante, anticancerígeno, antiinflamatório, diurético, nefroprotector, larvicida, analgésico, aditivo alimentario veterinario, antileishmanial, antipsoriasis, antidiarreico, antidiabético, hepatoprotector y antihelmíntico. Los estudios científicos analizados reafirman otras acciones reportadas de uso popular que no están descritas en los procesos de patente. Por lo tanto, existen muchas propiedades biológicas comprobadas de P. amboinicus que deberían explorarse y explotarse más a fondo en los sectores farmacéutico, cosmético y alimentrio para generar nuevos productos y patentes.
Citas
Akinbo, D. B., Onyeaghala, A. A., Emomidue, J. O., Ogbhemhe, S. O., & Okpoli, H. C. (2018). Phytochemical and anti-inflammatory activities of aqueous leaves extract of indian borage (oregano) on rats induced with inflammation. Cancer Biomark. 22 (2), 257-265. https://dx.doi.org/10.3233/CBM-170893.
Amarasiri, A. M. S. S., Attanayake, A. P., Jayatilaka, K. A. P. W., & Mudduwa, L. K. B. (2018). Acute nephroprotective and antioxidant activities of aqueous leaves extract of Plectranthus amboinicus (Roxb.) grown in Sri Lanka. J. Pharmacogn. Phytochem. 7 (4), 155-161. http://dx.doi.org/10.22271/phyto
Amparo, K. K. S., Ribeiro, M. C. O., & Guarineiro, L. L. N. (2012). Estudo de caso utilizando mapeamento de prospecção tecnológica como principal ferramenta de busca científica. Perspect. Ciênc. Inf. 17 (4), 195-209. https://doi.org/10.1590/S1413-99362012000400012
Arjunan, N., Murugan, K., Madhiyazhagan, P., Kovendan, K., Prasannakumar, K., Thangamani, S., & Barnard, D.R. (2012). Mosquitocidal and water purification properties of Cynodon dactylon, Aloe vera, Hemidesmus indicus and Coleus amboinicus leaves extracts against the mosquito vectors. Parasitol. Res. 110 (4), 1435-1443. https://dx.doi.org/10.1007/s00436-011-2646-3
Arumugam, G., Swamy, M. K., & Sinniah, U. R. (2016). Plectranthus amboinicus (Lour.) Spreng.: botanical, phytochemical, pharmacological and nutritional significance. Molecules. 21 (4), 1-26. https://dx.doi.org/10.3390/molecules-21040369
Asiimwe, S. (2015). Nutri-medicinal plants used in the management of HIV/AIDS opportunistic infections in Western Uganda: documentation, phytochemistry and bioactivity evaluation. [Doctoral dissertation, KTH Royal Institute of Technology]. Universites service US-AB Stockholm: Uganda. https://www.diva-portal.org/smash/record.jsf?pid=diva2%3A854066&dswid=1641
Bezerra, R. D. C. F., de Oliveira Neto, F. B., da Silva, F. F. M., Bertini, L. M., & Alves, L.A. (2017). Seasonal effect in essential oil composition and antioxidant activity of Plectranthus amboinicus leaves. Biosci. J. 33 (6), 1608-1616. https://doi.org/10.14393/BJ-v33n6a2017-37154.
Bhatt, P., & Negi, P. S. (2012). Antioxidant and antibacterial activities in the leaves extracts of indian borage (Plectranthus amboinicus). Food Nutr. Sci. 3, 146-152. http://dx.doi.org/10.4236/fns.2012.32022
Bhatt, P., Joseph, G. S., Negi, P. S., & Varadaraj, M. C. (2013). Chemical composition and nutraceutical potential of indian borage (Plectranthus amboinicus) stem extract. J. Chem. 2013. 1-7. https://dx.doi.org/10.1155/2013/320329
Bhatt P; & Shubha J. R. (2015). Plectranthus amboinicus leaves stimulate growth of probiotic l. Plantarum: evidence for ethnobotanical use in diarrhea. J. Ethnopharmacol. 166, 220-227. https://doi.org/10.1016/j.jep.2015.02.055
Bole, S., & Kumudini, J. (2014). Phytochemical screening and biological activities of medicinal plant Coleus aromaticus. WJPPS. 3 (6), 974-86. https://www.semanticscholar.org/paper/Phytochemical-screening-and-biological-activities-bole/57afa7cc1596203acf5802a41bb187d97ae4812a
Caruso, L. A., & Tigre, P. B. (2004). Modelo SENAI de prospecção: documento metodológico. Montevideo, CINTERFOR/OIT. https://www.oitcinterfor.org/node/6160
Chen, Y. S., Yu, H. M., Shie, J. J., Cheng, T. J. R., Wu, C. Y., Fang, J. M., & Wong, C. H. (2014). Chemical constituents of Plectranthus amboinicus and the synthetic analogs possessing anti-inflammatory activity. Bioorg. Med. Chem. 22 (5), 1766-1772. https://dx.doi.org/10.1016/j.bmc.2014.01.009.
Chiu, Y. J., Huang, T. H., Chiu, C. S., Lu, T. C., Chen, Y. W., Peng, W. H., & Chen, C. Y. (2012). Analgesic and antiinflammatory activities of the aqueous extract from Plectranthus amboinicus (Lour.) Spreng. both in vitro and in vivo. Evid. Based Complement. Alternat. Med. 508137. https://dx.doi.org/10.1155/2012/508137
Chuchuca, C. C., Quinche, Á. R. S., González, O. N. V., Flores, L. S. H., & Guerrero, J. N. Q. (2016). Use of vinegar and oreganón Plectranthus amboinicus (Lour.) Spreng. infusion for "Acriollados" bred broilers (Gallus gallus domesticus). Acta Agron. 65 (3), 298-303. https://dx.doi.org/10.15446/acag.v65n3.46222
Devi, K. N., & Periyanayagam, K. (2010). In vitro anti-inflammatory activity of Plectranthus amboinicus (Lour.) Spreng. by HRBC membrane stabilization. Int. J. Pharm. Sci. Res. 1 (1), 26-29. https://www.technicaljournalsonline.com/ijpsr/VOL%20I/IJPSR%20VOL%20I%20ISSUE%20I%20JULY%20SEPTEMBER%202010/IJPSR%20VOL%20I%20ISSUE%20I%20Article%204.pdf
Dutta, S., Lanvin, B., & Wunsch-Vincent, S. (2019). Global Innovation Index (GII) 2019: Creating healthy lives—the future of medical innovation. Itaca, Fontainebleau e Genebra: Cornell, INSEAD e OMPI. https://www.wipo.int/publications/en/details.jsp?id=4434
El-Hawary, S. S., El-Sofany, R. H., Abdel-Monem, A. R., Ashour, R. S., & Sleem, A. A. (2012). Polyphenolics content and biological activity of Plectranthus amboinicus (Lour.) Spreng. growing in Egypt (Lamiaceae). Pharmacogn. J. 4 (32), 45-54. http://dx.doi.org/10.5530/pj.2012.32.9
EL-Zefzafy, M. M., Dawoud, G. T., & El-Morsy, T. H. (2016). In vitro and in vivo growth, chemical and antimicrobial studies for Plectranthus amboinicus plant. Int. J. PharmTech. Res. 9 (12), 851-865. https://www.semanticscholar.org/paper/In-Vitro-and-In-Vivo-Growth%2C-Chemical-and-Studies-EL-Zefzafy-awoud/7759d616631db27c9c631219b7d26e6e3d5d2b1b
Gonçalves, T. B., Braga, M. A., Oliveira, F. M. de, Santiago, G M. P., Carvalho, C. B. M., Cabral, P. B., Santiago, T. M., Sousa, J. S., Barros, E. B., Nascimento, R. F., & Nagão-Dias, A. T. (2012). Effect of subinihibitory and inhibitory concentrations of Plectranthus amboinicus (Lour.) Spreng. essential oil on Klebsiella pneumoniae. Phytomedicine. 19 (11), 962-968. https://doi.org/10.1016/j.phymed.2012.05.013.
Gonçalves, T. B. (2017). Estudo in vitro e in vivo da atividade leishmanicida do extrato acetato de etila de Plectranthus amboinicus (Lour.) Spreng. frente à Leishmania (Viannia) braziliensis. [Doctoral dissertation, Federal of University of Ceara-Brasil]. http://www.repositorio.ufc.br/handle/riufc/40249
Haryani, R., Harahap, U., & Satria, D. (2018). Cytoprotective activity of ethanol fraction of Coleus amboinicus Lour. leaves against vero cells induced by H2O2. Asian J. Pharm. Clin. Res. 11 (1): 28-30. https://dx.doi.org/10.22159/APJCP.2018.v11s1.26559
Hasibuan, P. A. Z., Chrestella, J., & Satria, D. (2015). Combination effect of ethylacetate extracts of Plectranthus amboinicus (Lour.) Spreng. with doxorubicin against T47D breast cancer cells. Int. J. Pharm. Sci. 7 (10), 156-159. http://repository.usu.ac.id/handle/123456789/63699
Hasibuan, P. A. Z., Rosidah, I. S., & Nasution, M. P. (2013). Antioxidant and cytotoxic activities of Plectranthus amboinicus (Lour.) Spreng. extracts. IJPTP. 4 (3), 755-758. https://www.iomcworld.org/abstract/antioxidant-and-cytotoxic-activities-of-plectranthus-amboinicus-lour-spreng-extracts-43935.html
Hasibuan, P. A. Z., & Rosidah, R. (2015). Combination effect of n-hexane extract of Plectranthus amboinicus (Lour.) Spreng. with doxorubicin against HeLa cell lines. ISCC. 6 (3), 111-115. https://dx.doi.org/10.14499/indonesianjcanchemoprev6iss3pp111-115
Hasibuan, P. A. Z., & Sumaiyah, S. (2019). The anti-proliferative and pro-apoptotic properties of ethanol Plectranthus amboinicus (Lour.) Spreng. leaves ethanolic extract nanoparticles on T47D cell lines. Asian Pac. J. Cancer Prev. 20 (3), 897–901. https://doi.org/10.31557/APJCP.2019.20.3.897
Hassani, M., Saïd, Zainati, I., Zrira, S., Mahdi, S., & Oukessou, M. (2012). Chemical composition and antimicrobial activity of Plectranthus amboinicus (Lour.) Spreng. essential oil from archipelago of Comoros. J. Essent. Oil-Bear Plants. 15, 637-644. https://doi.org/10.1080/0972060X.2012.10644098
Ismayil, S., & Nimila, P. J. (2019). Antimicrobial activity of Plectranthus amboinicus (Lour.) against gram-negative bacteria klebsiella pneumoniae and Shigella flexneri and their phytochemical tests. Int. J. Health Sci. Res. 9 (5), 304-311. https://www.ijhsr.org/IJHSR_Vol.9_Issue.5_May2019/45.pdf
León Méndez, G., Fortich, O., del Rosario, M., Torrenegra, M. E., & González, J. G. (2015). Extracción, caracterización y actividad antioxidante del aceite esencial de Plectranthus amboinicus L. Rev. Cuba. de Farm. 49 (4), 708-718. http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75152015000400011
Leu, W. J., Chen, J. C., & Guh, J. H. (2019). Extract from Plectranthus amboinicus inhibit maturation and release of interleukin 1β through inhibition of NF-κB nuclear translocation and NLRP3 inflammasome activation. Front. Pharmacol. 10, 1-12. https://doi.org/10.3389/fphar.2019.00573
Lima, S. C. G., Teixeira, M. J., Lopes Júnior, J. E. G., de Morais, S. M., Torres, A. F., Braga, M. A., Rodrigues, R. O., Santiago, G. M. P., Martins, A. C., & Nagão-Dias, A. T. (2014). In vitro and in vivo leishmanicidal activity of Astronium fraxinifolium (Schott) and Plectranthus amboinicus (Lour.) Spreng. against Leishmania (Viannia) braziliensis. Biomed. Res. Int. 2014, 1-7. https://dx.doi.org/10.1155/2014/848
Majee, C., Das, G. K., Mazumder, R., & Chakraborthy, G. S. (2013). Evaluation of analgesic and antimicrobial potential of hydroalcoholic extract of leaves of Coleus aromaticus in albino mice. J. Phytopharmacol. 2 (3), 18-25. https://dx.doi.org/10.31254/phyto
Manimekalai, K., Srinivasan, P., Dineshbabu, J., Guna, G., & Darsini, D. T. P. (2016). Anti-biofilm efficacy of Plectranthus amboinicus against Streptococcus pyogenes isolated from pharyngitis patients. Asian J. Pharm. Clin. Res. 9 (4), 348-354. https://innovareaademics.org/journals/index.php/ajpcr/article/download/12337/5862.
Manjamalai, A., Alexander, T., & Grace, V. B. (2012). Bioactive evaluation of the essential oil of Plectranthus amboinicus by GC-MS analysis and its role as a drug for microbial infections and inflammation. Int. J. Pharm. Sci. 4 (3), 205-211. https://innovareacademics.in/journals/index.php/ijpps
Manojkanna, K. Chandana, C. S., Gayathri, R., Priya, V. V., & Geetha, R. (2017). Synthesis and characterization of silver nano particles from Plectranthus ambionicus extract and its antimicrobial activity against Enterococcus faecalis and Candida albicans. J. Pharm. Sci. & Res. 9 (12), 2423-2425. https://www.jpsr.pharmainfo.in/Documents/Volumes/vol9Issue12/jpsr09121723.pdf
Manojkanna, K., Nasim, I., Gayathri, R., & Priya, V. V. (2019). Synthesis and characterization of silver nanoparticles from Plectranthus amboinicus extract and its antimicrobial activity against Streptococcus mutans, Lactobacillus. DIT. 12 (6), 1236-1238. https://jprsolutions.info/article_detail.php?article_id=3666
Oliveira, M. M. M., & Quental, C. M. (2012). The technology foresight as a strategic planning tool for the future construction of the Oswaldo Cruz Institute. RECIIS. 6 (1), 50-61. https://www.reciis.icict.fiocruz.br/index.php/reciis
Oliveira, F. F. M., Torres, A. F., Gonçalves, T. B., Santiago, G. M. P., de Carvalho, C. B. M., Aguiar, M. B., & Nagão-Dias, A. T. (2013). Efficacy of Plectranthus amboinicus (Lour.) Spreng. in a murine model of methicillin-resistant Staphylococcus aureus skin abscesses. Evid. Based. Complement. Alternat. Med. 2013, 1-9. https://dx.doi.org/10.1155/2013/291592
Palani, S., Raja, S., Naresh, R., & Kumar, B. S. (2010). Evaluation of nephroprotective, diuretic, and antioxidant activities of Plectranthus amboinicus on acetaminophen-induced nephrotoxic rats. Toxicol. Mech. Method. 20 (4), 213-221. https://doi.org/10.3109/15376511003736787
Patel, R. D., Mahobia, N. K., Singh, M. P., Singh, A., Sheikh, N. W., Alam, G., & Singh, S. K. (2010a). Antioxidant potential of leaves of Plectranthus amboinicus (Lour.) Spreng. Pharm. Lett. 2 (4), 240-245. . https://www.scholarsresearchlibrary.com/abstract/antioxidant-potential-of-leaves-of-plectranthus-amboinicus-lourrnspreng-4809.html
Patel, R., Mahobia, N. K., Gendle, R., Kaushik, B., & Singh, S. K. (2010b). Diuretic activity of leaves of Plectranthus amboinicus (Lour.) Spreng. in male albino rats. Pharmacogn. Res. 2 (2), 86. https://doi.org/10.4103/0974-8490.62956
Patel, R. (2011). Hepatoprotective effects of Plectranthus amboinicus (Lour.) Spreng. against carbon tetrachloride-induced hepatotoxicity. J. Nat. Pharm. 2 (1), 28-35. https://doi.org/10.4103/2229-5119.78495
Prasenjit, B., Hullatti, K. K., & Vijay, K. M. L. (2011). Anthelmintic and antioxidant activity of alcoholic extracts of different parts of Coleus amboinicus Lour. Int. J. Res. Ayurveda. Pharm. 1 (1), 181-185. https://ijrap.net/index.php/login/abstractt?id=386
Rosidah, & Hasibuan, P. A. Z. (2014). Cytotoxic effect of n-hexane, ethylacetate and ethanol extracts of Plectranthus amboinícus (Lour.) Spreng. on hela and vero cells lines. IJPRIF. 6 (6), 1806-1809. https://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.1089.5078&rep=rep1&type=pdf
Ruan, T. Z., Kao, C. L., Hsieh, Y. L., Li, H. T., & Chen, C. Y. (2019). Chemical constituents of the leaves of Plectranthus amboinicus. Chem. Nat. Compd. 55 (1), 124-126. https://doi.org/10.1007/s10600-019-02631-9
Sahrial, I., & Solfaine, R. (2019). Coleus amboinicus extract increases transforming growth factor-1β expression in wistar rats with cisplatin-induced nephropathy. Vet. World. 12 (8), 1346-1351. https://doi.org/10.14202/vetworld.2019.1346-1351
Santos, F. A., Serra, C. G., Bezerra, R. J., Figueredo, F. G., Matias, F. F., Menezes, I. R., Costa, J. G. M., & Coutinho, H. D. (2016). Antibacterial activity of Plectranthus amboinicus Lour (Lamiaceae) essential oil against Streptococcus mutans. Eur. J. Integr. Med. 8 (3), 293-297. https://doi.org/10.1016/j.eujim.2015.11.021
Senthilkumar, A., & Venkatesalu, V. (2010). Chemical composition and larvicidal activity of the essential oil of Plectranthus amboinicus (Lour.) Spreng. against Anopheles stephensi: a malarial vector mosquito. Parasitol. Res. 107 (5), 1275-1278. https://doi.org/10.1007/s00436-010-1996-6
Silveira, R. C. C. P (2005). O cuidado de enfermagem e o cateter de Hickman: a busca de evidências. Acta Paulista de Enfermagem, 18 (3): 276-84. https://doi.org/10.1590/S0103-21002005000300008.
Sireesha, N., Kumar, D. V., Supriya, E., Suma, C., Hemanth, N., & Ramanarayana, C. (2017). Antimicrobial Effect of Plectranthus amboinicus and Ocimum tenuiflorum against Mycobacterium tuberculosis. World J. Pharm. Pharm. Sci. 6 (8), 1008-1017. https://doi.org/10.20959/wjpps20178-9674
Sivaranjani, D., Saranraj, P., Manigandan, M., & Amala, K. (2019). Antimicrobial activity of Plectranthus amboinicus solvent extracts against human pathogenic bacteria and fungi. JDDT. 9 (3), 36-9. https://doi.org/10.22270/jddt.v9i3.2604
Souto-Maior, F. N., De Carvalho, F. L., De Morais, L. C. S. L., Netto S. M., De Sousa, D. P., & Almeida, R. N. (2011). Anxiolytic-like effects of inhaled linalool oxide in experimental mouse anxiety models. Pharmacol. Biochem. Behav. 100 (2), 259-63. https://doi.org/10.1016/j.pbb.2011.08.029
Souza, M. T., Silva, M. D., & Carvalho, R. (2010). Revisão integrativa: o que é e como fazer. Einstein (São Paulo), 8 (1), 102-106. https://dx.doi.org/10.1590/s1679-45082010rw1134
Sreelakshmy, S., & Thangapandiyan, S. (2019). In vitro antibacterial efficacy of Plectranthus amboinicus mediated silver nanoparticles against urinary tract pathogens in vitro. Asian J. Pharm. Clin. Res. 12 (2), 153-159. https://doi.org/10.22159/ajpcr.2019.v12i2.28079
Thirugnanasampandan, R., Ramya, G., Gogulramnath, M., Jayakumar, R., & Kanthimathi, M. S. (2015). Evaluation of cytotoxic, DNA protecting and LPS induced MMP-9 down regulation activities of Plectranthus amboinicus (Lour) Spreng. essential oil. Pharmacogn. J. 7 (1), 32-36. https://doi.org/10.5530/pj.2015.7.3
Vasconcelos, S. E. C. B., Melo, H. M., Cavalcante, T. T. A., Júnior, F. E. A. C., de Carvalho, M. G., Menezes, F. G. R., Sousa, O. V. de, & Costa, R. A. (2017). Plectranthus amboinicus essential oil and carvacrol bioactive against planktonic and biofilm of oxacillin-and vancomycin-resistant Staphylococcus aureus. BMC Complement. Altern. Med. 17 (1), 462. https://doi.org/10.1186/s12906-017-1968-9
Vijayakumar, S. , Vinoj, G., Malaikozhundan, B., Shanthi, S., & Vaseeharan, B. (2015). Plectranthus amboinicus leaves extract mediated synthesis of zinc oxide nanoparticles and its control of methicillin resistant Staphylococcus aureus biofilm and blood sucking mosquito larvae. Spectrochim. Acta A. Mol. Biomol. Spectrosc. 18 (3), 886-891. https://doi.org/10.1016/j.saa.2014.08.064.
Vijayalakshmi, A., Priyanka, M., Priyadharshini, S., Kumar, S., Jayakumari, S., & Ravichandiran, V. (2019). Evaluation of herbal ointment containing ethanol extract of Plectranthus amboinicus root for the management of psoriasis. Indian J. Tradit. Know. 18 (3), 553-559. http://op.niscair.res.in/index.php/IJTK/article/view/26743
Zhang, B., Wijesundara, N. M., Abbey, L., & Rupasinghe, H. V. (2017). Growing medium amendments effect on growth, secondary metabolites and anti-streptococcal activity of two species of Plectranthus. J. Appl. Res. Med. Aromat. Plants. 5, 53-59. https://doi.org/10.1016/j.jarmap.2016.11.001
Yanza, Y. R., Szumacher-Strabel, M., Bryszak, M., Gao, M., Kolodziejski, P., Stochmal, A., Slusarczyk, S., Patra, A.K., & Cieslak, A. (2018). Coleus amboinicus (Lour.) leaves as a modulator of ruminal methanogenesis and biohydrogenation in vitro. J. Anim. Sci. 96 (11), 4868-4881. https://doi.org/10.1093/jas/sky321
Yulianto, W., Andarwulan, N., Giriwono, P. E., & Pamungkas, J. (2017). Bioactive compounds from torbangun Plectranthus amboinicus (Lour.) Spreng. chloroform fraction induce apoptosis in breast cancer (MCF-7 cells) in vitro. Trad. Med. J. 22 (1), 37-44. https://doi.org/10.22146/tradmedj.24312
Descargas
Publicado
Cómo citar
Número
Sección
Licencia
Derechos de autor 2021 Elizabeth Regina de Castro Borba; Haymê dos Santos Ferreira; Thiago Castro Mubárack; Tássio Rômulo Silva Araújo Luz; Daniella Patrícia Brandão Silveira; Ana Zélia Silva; Patrícia de Maria Silva Figueiredo; Odair dos Santos Monteiro; Yan Michel Lopes Fernandes; Crisálida Machado Vilanova; Denise Fernandes Coutinho
Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
Los autores que publican en esta revista concuerdan con los siguientes términos:
1) Los autores mantienen los derechos de autor y conceden a la revista el derecho de primera publicación, con el trabajo simultáneamente licenciado bajo la Licencia Creative Commons Attribution que permite el compartir el trabajo con reconocimiento de la autoría y publicación inicial en esta revista.
2) Los autores tienen autorización para asumir contratos adicionales por separado, para distribución no exclusiva de la versión del trabajo publicada en esta revista (por ejemplo, publicar en repositorio institucional o como capítulo de libro), con reconocimiento de autoría y publicación inicial en esta revista.
3) Los autores tienen permiso y son estimulados a publicar y distribuir su trabajo en línea (por ejemplo, en repositorios institucionales o en su página personal) a cualquier punto antes o durante el proceso editorial, ya que esto puede generar cambios productivos, así como aumentar el impacto y la cita del trabajo publicado.
