Ácidos grasos insaturados como alimento funcional para el tratamiento de la Diabetes mellitus tipo 2
DOI:
https://doi.org/10.33448/rsd-v10i9.17231Palabras clave:
Ácidos Grasos Monoinsaturados; Compuestos bioactivos; Propiedades funcionales; Resistencia a la insulina; Transportador de glucosa tipo 4.Resumen
Varios estudios apuntan a una relación entre los ácidos grasos insaturados, la función pancreática mejorada y la secreción de insulina. En este contexto, esta revisión presenta los hallazgos más recientes sobre la fisiopatología de la diabetes mellitus tipo 2, el mecanismo de acción de los ácidos grasos insaturados sobre la función pancreática y los estudios clínicos en pacientes diabéticos. Aquí evaluamos artículos de MedLine/PubMed y la base de datos directa de Science, publicados entre 2014 y 2020. De los 637 resultados, se seleccionaron 13. A partir de su análisis, vemos evidencia de que los ácidos grasos mono y poliinsaturados pueden mejorar el control glucémico y reducir el riesgo cardiovascular. La acción antidiabética más citada en la literatura con respecto a los ácidos grasos monoinsaturados es la capacidad de preservar la señalización de la insulina; por otro lado, el de los ácidos grasos poliinsaturados consiste en un aumento de la expresión del transportador de glucosa tipo 4. Sin embargo, en futuras investigaciones se debe considerar una comprensión completa de la relación entre los ácidos grasos, la insulina y la inflamación.
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Derechos de autor 2021 Naiane Silva Cardoso; Julia Rosental de Souza Cruz; Ramon Alves de Oliveira Paula; Stella Maris da Silveira Duarte; Maria Rita Rodrigues; Fernanda Borges de Araújo Paula
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