Ácidos graxos insaturados como alimento funcional para o tratamento de Diabetes mellitus Tipo 2
DOI:
https://doi.org/10.33448/rsd-v10i9.17231Palavras-chave:
Ácidos Graxos Monoinsaturados; Compostos bioativos; Propriedades funcionais; Resistencia à insulina; Transportador de glicose tipo 4.Resumo
Diversas pesquisas apontam para uma relação entre ácidos graxos insaturados, melhora da função pancreática e secreção de insulina. Nesse contexto, esta revisão apresenta os achados mais recentes sobre a fisiopatologia do diabetes mellitus tipo 2, o mecanismo de ação dos ácidos graxos insaturados na função pancreática e os estudos clínicos em pacientes diabéticos. Avaliamos aqui artigos do MedLine/PubMed e da base de dados Science direct, publicados entre 2014 e 2020. Dos 637 resultados, 13 foram selecionados. A partir da sua análise, observamos evidências de que ácidos graxos mono e poliinsaturados podem melhorar o controle glicêmico, bem como reduzir o risco cardiovascular. A ação antidiabética mais citada na literatura quanto aos ácidos graxos monoinsaturados é a capacidade de preservação da sinalização da insulina; já a dos ácidos graxos poliinsaturados consiste no aumento da expressão do transportador de glicose tipo 4. Entretanto, a compreensão completa da relação entre ácidos graxos, insulina e inflamação deve ser considerada em investigações futuras.
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Copyright (c) 2021 Naiane Silva Cardoso; Julia Rosental de Souza Cruz; Ramon Alves de Oliveira Paula; Stella Maris da Silveira Duarte; Maria Rita Rodrigues; Fernanda Borges de Araújo Paula
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