Efectos del uso de polifenoles en la terapia del Cáncer de Cabeza y Cuello: Revisión integral

Autores/as

DOI:

https://doi.org/10.33448/rsd-v10i9.17804

Palabras clave:

Neoplasias de Cabeza y Cuello; Polifenoles; Terapéutica.

Resumen

Los cánceres de cabeza y cuello (CCC) tienen una alta tasa de morbilidad y mortalidad, incluso después de los avances tecnológicos en la terapia convencional del cáncer. Así, el estudio de terapias adyuvantes, como el uso de polifenoles, presenta potenciales resultados en el tratamiento del CCP. Esta revisión tuvo como objetivo identificar los efectos del uso de polifenoles en el tratamiento del CCP. Se realizó una revisión integradora mediante la herramienta PICo, realizando la búsqueda en cuatro bases de datos electrónicas, utilizando los términos “Polifenoles”, “Cáncer de cabeza y cuello” y “Terapia”, además de su correspondencia en inglés y español. Un total de 25 artículos componen la muestra de estudio. La estrategia de extracción de datos buscó identificar principalmente el compuesto, el mecanismo de acción, los principales resultados, el nivel de evidencia y el diseño del estudio. El diseño de estudio más prevalente fue "revisión" e "in vitro" y la revisión identificó que los compuestos más utilizados fueron la curcumina y el resveratrol. Casi unánimemente, los estudios apuntaron a los efectos antineoplásicos de los polifenoles en el PCC, activando los mecanismos de muerte celular y reducción de tumores, de varias formas. Así, considerando el efecto de las terapias convencionales para la PCC, así como su resultado clínico, el uso de polifenoles es una opción potencial y prometedora, que impulsa el desarrollo de investigaciones que aborden en detalle los mecanismos celulares, los efectos adversos y las dosis.

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Publicado

23/07/2021

Cómo citar

RAMIREZ, I.; FEITOZA, L. Q.; SOARES, L. F. F. .; TERRA, F. de S. . Efectos del uso de polifenoles en la terapia del Cáncer de Cabeza y Cuello: Revisión integral. Research, Society and Development, [S. l.], v. 10, n. 9, p. e15210917804, 2021. DOI: 10.33448/rsd-v10i9.17804. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/17804. Acesso em: 26 sep. 2024.

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