Mucositis oral en niños con cáncer: dificultades en la evaluación y terapia eficaz

Autores/as

DOI:

https://doi.org/10.33448/rsd-v10i11.20018

Palabras clave:

neoplasia; Neoplasia; Quimioterapia; quimioterapia; mucositis; Mucositis; protocolo; Protocolo.

Resumen

El cáncer es un problema de salud pública en el mundo y, en los niños, la incidencia de aumento es de alrededor del 1% anual. A pesar de su eficacia, la terapia antineoplásica provoca efectos de importante toxicidad, provocando a menudo la hospitalización del paciente, dificultad para continuar con la oncoterapia o no readaptación al tratamiento por la no progresión de la enfermedad. La mucositis oral es uno de los efectos deletéreos más comunes; causa dolor, afecta el habla y la nutrición y hace que el paciente sea susceptible a la sepsis. En los niños, la frecuencia de la mucositis oral es de alrededor del 65%. Sus manifestaciones se evalúan utilizando diferentes escalas y se tratan con diferentes protocolos. El objetivo de este trabajo es verificar, en una revisión sistemática de la literatura, el estado del arte en la evaluación de la mucositis oral en niños sometidos a tratamiento oncológico. Los estudios han demostrado que la evaluación es fundamental para establecer estrategias de tratamiento, que los protocolos y escalas utilizados son inconsistentes y que no existe un sistema viable y válido para puntuar la mucositis infantil por cáncer, evitando una intervención terapéutica más eficaz. Se concluyó que la Children's International Mucositis Evaluation Scale ha sido la escala con mayor aceptabilidad y validez según sus criterios.

Citas

Aggarwal R., Bansal D., Naru J., Salaria M., Rana A., Minz RW., Trehan A. & Marwaha K. (2014). HSV-1 as well as HSV-2 is frequent in oral mucosal lesions of children on chemotherapy. Support Care Cancer, 22, 1773–1779.

Allen G., Logan R .& Gue S. (2020). Oral manifestations of cancer treatment in children: a review of the literature. Clinical Journal of Oncology Nursing, 14 (4), 481-490.

Argelagós A.P., Cárdenas A.B.C. & Blanco J.R., (2014). Protocolos de atención odontológica a pacientes pediátricos oncológicos. Odontol Pediátr, 22 (2),153-161.

Botelho, L. L. R., de Almeida Cunha, C. C., & Macedo, M. (2011). O método da revisão integrativa nos estudos organizacionais. Gestão e sociedade, 5(11), 121-136

Bourdelin M., Daguindau E., Larosa F., Legrand F., Nerich V. & Deconinck E., Limat S. (2015). La mucite post-allogreffe de cellules souches he´matopoı¨e´tiques: facteurs de risque, conse´quences cliniques et pre´vention. Pathologie Biologie, 63, 106–110.

Bulut H.K.& Tüfekci F.G. (2016). Honey prevents oral mocositis in children undergoing chemotherapy: A quasi-experimental study with a control group. Complementary Therapies in Medicine, 29, 132–140.

Castro J.F.L., Abreu E.G.F., Correia A.V.L., Brasil C.M.V., Perez D.E.C. & Pedroso F.P.R. (2013). Low-level laser in prevention and treatment of oral mucositis in pediatric patients with acute lymphoblastic leukemia. Photomedicine and Laser Surgery, 31 (12), 613–618.

Devi K.S. & Allenidekaniab A. (2019). The relationship of oral care practice at home with mucositis incidence in children with acute lymphoblastic leukemia. Comprehensive Child and Adolescent Nursing, 42 (S1), 56–64.

Figliolia S.L.C., Oliveira D.T., Pereira M.C., Lauris J.R.P, Maurício A.R., Oliveira D.T. & Mello de Andrea M.L.(2008). Oral mucositis in acute lymphoblastic leukaemia: analysis of 169 paediatric patients. Oral Diseases, 14, 761–766.

Garrocho-Rangel J.A., Herrera-Moncada M., Márquez-Preciado R., Tejeda-Nava F., Ortiz-Zamudio J.J. & Pozos-Guillén A. (2018). Oral mucositis in paediatric acute lymphoblastic leukemia patients receiving methotrexate-based chemotherapy: case series. European Journal of Paediatric Dentistry, 9/3.

Hashemi A., Bahrololoumi Z., Khaksar Y., Saffarzadeh N., Neamatzade H. & Foroughi E. (2015). Mouth-rinses for the prevention of chemotherapy induced oral mucositis in children: a systematic review. Iranian Journal of Pediatric Hematology Oncology, 15 (2).

Jacobs S., Baggott C., Agarwal R., Hesser T., Schechter T., Judd P., Tomlinson D., Beyene J. & Sung L. (2013). Validation of the Children’s International Mucositis Evaluation Scale (ChIMES) in paediatric cancer and SCT. British Journal of Cancer, 109, 2515–2522.

Kuhn A., Porto F.A., Miraglia P. & Brunetto A.L. (2009) Low-level infrared laser therapy in chemotherapy-induced oral mucositis. A randomized placebo-controlled trial in children. J Pediatr Hematol Oncol, 31 (1), 33-8.

Mendonça R.M.H., Araujo M., Levy C.E., Morari J., Silva R.A. & Yunes JA, Brandalise SR. (2015). Oral mucositis in pediatric acute lymphoblastic leukemia patients: evaluation of microbiological and hematological factors. Pediatric Hematology and Oncology, 1(9).

Otmani N., Raouf A., Hessissen L.L., Mokhtari A., Soulaymani A. & Khattab M. (2011). Determinants of severe oral mucositis in paediatric cancer patients: a prospective study. International Journal of Paediatric Dentistry, 21, 210– 216.

Paiva B.S.R., Barroso E.M., Cadamuro S.A., Paula L.A.B., Pirola W.E, Serrano C.V.M.P. & Paiva CE. (2018).The Children’s International Mucositis Evaluation Scale is valid and reliable for the assessment of mucositis among brazilian children with cancer. Journal of Pain and Sympton Management, 56(5),774-783.

Schubert M.M., Williams B.E., Lloid M.E., Donaldson G. & Chapko M.K. (1992). Clinical assessment scale for the rating of oral mucosal changes associated with bone marrow transplantation: development of an oral mucositis index. Cancer, 69, 2469-77. Recuperado em 1 fevereiro 2021, de https://acsjournals.online library.wiley.com/doi/pdfdirect/10.1002/1097-0142(19920515)69.

Singh R., Sharma S., Kaur S., Medhi B., Trehan A. & Bijarania SK. (2019) Effectiveness of topical application of honey on oral mucosa of children for the management of oral mucositis associated with chemotherapy. The Indian Journal of Pediatrics, 86(3), 224–228.

Sonis S. T., Eilers J.P., Epstein J.B., Le Veque F.G., Liggett Jr W.H .& Mulagha MT.(1999) Validation of a new scoring system for the assessment of clinical trial research of oral mucositis induced by radiation or chemotherapy. Am Cancer Soc. 85, 2103-13.

Stiff P.J., Erder H., Bensinger W.I., Emmanouilides C., Gentile T., Isitt J., Lu Z.J. & Spielberger R. (2006) Reliability and validity of a patient self-administered daily questionnaire to assess impact of oral mucositis (OM) on pain and daily functioning in patients undergoing autologous hematopoietic stem cell transplantation (HSCT). Bone Marrow Transplantation, 37(4),393–401.

Sung L., Robinson P., Treister N., Baggott T., Gibson P., Tissing W., Wiernikowski J. & Brinklow J, Dupuis LL.(2017) Guideline for the prevention of oral and oropharyngeal mucositis in children receiving treatment for cancer or undergoing haematopoietic stem cell transplantation. Supportive & Palliative Care, 7, 7–16.

Tomlinson D., Gibson F., Treister N., Baggott C., Judd J.P., Hendershot E., Maloney A.M., Doyle J., Feldman B., Kwong K. & Sung L. (2009a) Understandability, content validity, and overall acceptability of the Children’s International Mucositis Evaluation Scale (ChIMES) Child and parent reporting. J Pediatr Hematol Oncol, 31 (6), 416-24.

Tomlinson D., Gibson F., Treister F., Baggott C., Judd P., Hendershot E., Maloney A.M., Doyle J., Feldman B., Kwong K. & Sung L. (2010a) Refinement of the Children’s International Mucositis Evaluation Scale (ChIMES): child and parent perspectives on understandability, content validity and acceptability. European Journal of Oncology Nursing, 14, 29-41.

Tomlinson D., von Baeyer C.L., Stinso J.N. & Sung L. (2010b) A systematic review of faces scales for the self-report of pain intensity in children. Pediatrics, 126(5), 1168-98. Recuperado em 2 fevereiro 2021, de https:// pubmed.ncbi.nlm.nih.gov/20921070/

WHO World Health Organization. (1979) WHO handbook for reporting results of cancer treatment. Recuperado em 1 de fevereiro de 2021, de https://apps.who.int/iris/handle/10665/37200.

Publicado

05/09/2021

Cómo citar

MUNIZ, A. B.; HOLANDA , M. A. R. de .; ABREU, K. N. de .; MACEDO, S. B. .; BESSA, E. R. L. .; LEITE, L. D. P. .; VEGIAN, M. R. da C. .; CAVALCANTE, R. R. de H. .; RODRIGUES, R. A. . Mucositis oral en niños con cáncer: dificultades en la evaluación y terapia eficaz. Research, Society and Development, [S. l.], v. 10, n. 11, p. e435101120018, 2021. DOI: 10.33448/rsd-v10i11.20018. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/20018. Acesso em: 23 nov. 2024.

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