Comparación del uso de Solidago chilensis (Árnica) y la terapia con láser de baja intensidad para la prevención de la mucositis oral en pacientes sometidos a radioterapia de cabeza y cuello y / o quimioterapia de alta toxicidade
DOI:
https://doi.org/10.33448/rsd-v10i14.22128Palabras clave:
Arnica; Terapia con láser; Mucositis oral; Solidago chilensis; Solidago microglossus.Resumen
La mucositis oral es un efecto adverso resultante de la radioterapia de cabeza y cuello y / o quimioterapia de alta toxicidad. Solidago chilensis (Árnica) se ha utilizado por sus propiedades antisépticas, analgésicas, cicatrizantes y antiinflamatorias. Metas: Este estudio tuvo como objetivo evaluar el uso de Árnica para la prevención de la mucositis oral en pacientes sometidos a radioterapia para el tratamiento de tumores de cabeza y cuello y / o quimioterapia de alta toxicidad. Metodología: La determinación del índice de citotoxicidad del extracto acuoso se determinó in vitro. Se evaluó la mucosa oral en los días 0, 10 y 14 de los pacientes de los grupos: tratados con láser (L, n = 18), tratados con Árnica (A, n = 24) y tratados con láser asociado a Árnica (LA , n = 4). Se consideró significativo p <0,05. Resultados: Se determinó IC50 = 90,74 μg / mL del extracto acuoso de Árnica en células SCC-4. El desarrollo de mucositis oral se asoció con el tipo de tratamiento para prevenir la mucositis oral: L, A y LA (χ2 = 24,72, p <0,0001). El grado de mucositis oral tuvo una interacción significativa con el tipo de tratamiento preventivo [F (2) = 9.545, p <0.0001] y en el transcurso de 14 días [F (2) = 11.995, p <0.0001]. Conclusión: Los resultados obtenidos sugieren que el uso de Solidago chilensis (Árnica) puede ser una opción terapéutica importante para el tratamiento con láser de baja intensidad para la prevención de la mucositis oral en pacientes sometidos a radioterapia de cabeza y cuello y / o quimioterapia de alta toxicidad.
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Derechos de autor 2021 Ana Cristina Lopes; Giovana Ferreira Gonçalves; Anna Cecília Dias Maciel Carneiro; André Luiz Pantoja dos Santos; Frederico Nobrega Tomas; Leonardo Rodrigues de Oliveira; Karina Ferrazzoli Devienne; Virginia Oliveira Crema
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