Comparação do uso de Solidago chilensis (Arnica) e laserterapia de baixa intensidade para prevenção de mucosite oral em pacientes submetidos radioterapia de cabeça e pescoço e/ou à quimioterapia de alta toxicidade
DOI:
https://doi.org/10.33448/rsd-v10i14.22128Palavras-chave:
Arnica; Laserterapia; Mucosite oral; Solidago chilensis; Solidago microglossus.Resumo
A mucosite oral é um efeito adverso, decorrente da radioterapia de cabeça e pescoço e/ou à quimioterapia de alta toxicidade. A Solidago chilensis (Arnica) tem sido utilizada por possuir propriedades antissépticas, analgésicas, cicatrizantes e anti-inflamatórias. Objetivo: Este estudo visou avaliar o uso de Arnica para a prevenção de mucosite oral em pacientes submetidos à radioterapia para tratamento de tumores de cabeça e pescoço e/ou quimioterapia de alta toxicidade. Metodologia: A determinação do índice de citotoxicidade do extrato aquoso foi determinada in vitro. A mucosa oral foi avaliada nos dias 0, 10 e 14 de pacientes dos grupos: tratados com laserterapia (L, n=18), tratados com Arnica (A, n=24) e tratados com laserterapia associada à Arnica (LA, n=4). Foi considerado significante p<0,05. Resultados: Foi determinado IC50=90,74 μg/mL do extrato aquoso de Arnica em células SCC-4. O desenvolvimento de mucosite oral foi associado ao tipo de tratamento para prevenção de mucosite oral: L, A e LA (χ2 = 24,72, p<0,0001). O grau de mucosite oral teve interação significante com o tipo de tratamento preventivo [F(2) = 9,545, p<0,0001] e com o decorrer do tempo de 14 dias [F(2) = 11,995, p<0, 0001]. Conclusões: Os resultados obtidos sugerem que o uso da Solidago chilensis (Arnica) pode ser uma opção terapêutica importante para o tratamento com a laserterapia de baixa intensidade para a prevenção da mucosite oral em pacientes submetidos radioterapia de cabeça e pescoço e/ou à quimioterapia de alta toxicidade.
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