Cambios en el gusto resultantes de la quimioterapia convencional
DOI:
https://doi.org/10.33448/rsd-v10i14.22467Palabras clave:
Antineoplásticos; Gusto distorsionado; Disgeusia; Estomatita; Cavidad oral.Resumen
El cáncer está relacionado con el aumento desordenado de células, tiene la capacidad de invadir los tejidos vecinos en el lugar de origen y / o instalarse en órganos distantes a través del torrente sanguíneo. El tratamiento antineoplásico puede generar efectos secundarios en la mucosa bucal, siendo evidentes por la aparición de mucositis bucal. También podemos observar cambios en el gusto, como: hipogeusia, disgeusia, ageusia e hipergeusia. El presente trabajo tiene como objetivo revisar la literatura sobre las alteraciones del gusto causadas por 5-fluorouracilo (5-FU), leucovorina, oxaliplatino, gemcitabina, capecitabina, cisplatino, ciclofosfamida, doxorrubicina, irinotecán y metotrexato, siendo fármacos antineoplásicos convencionales. Este estudio se llevó a cabo mediante la recolección de datos de 2009 a 2021, de la literatura científica en las bases de datos PubMed, Lilacs, Cochrane y Scielo en inglés y español, utilizando las palabras clave Antineoplásticos; Sabor distorsionado; Disgeusia; Estomatitis; Cavidad oral; junto con los operadores booleanos “y” y “o”, con el fin de combinar los descriptores antes mencionados. Dado lo anterior, los fármacos quimioterápicos convencionales afectan las células gustativas y los procesos bioquímicos relacionados con su renovación celular, generando cambios en el gusto como hipogeusia, disgeusia, ageusia e hipergeusia.
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Derechos de autor 2021 Eduardo Henrique dos Santos Silva; Yuri Lopes de Aguiar; Polyana Argolo Souza Amaral; Lara Correia Pereira
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