Resistencia a los carbapenémicos por Acinetobacter spp. reportado a GLASS según el nivel de ingresos de los países

Autores/as

DOI:

https://doi.org/10.33448/rsd-v10i17.24115

Palabras clave:

Pruebas de sensibilidad microbiana; Utilización de medicamentos; Monitoreo epidemiológico; Farmacorresistencia bacteriana.

Resumen

Este trabajo tiene como objetivo evaluar la resistencia a los carbapenémicos de Acinetobacter spp. informaron al GLASS (Global Antimicrobial Resistance and Use Surveillance System), estratificando estos datos por tramo de ingreso per cápita. Se realizó un estudio observacional retrospectivo sobre la sensibilidad a carbapenémicos de Acinetobacter spp., reportado a GLASS, incluyendo todos los datos disponibles al momento de la recolección, febrero de 2021, estratificando estos hallazgos por nivel de ingresos de cada país y número de pruebas de sensibilidad a carbapenémicos realizadas. Los países de ingresos más altos registraron la no susceptibilidad más baja, pero dentro de ellos hay ejemplos que tienen una alta incidencia de no susceptibilidad. Para los cuatro grupos de ingresos hubo una alta variación de desviación estándar para la media de las pruebas de sensibilidad a los carbapenémicos, lo que reveló puntos de inconsistencia. Los datos trabajados en este artículo muestran un nivel preocupante de resistencia a los carbapenémicos observado en GLASS. Incluso dentro de los países ricos, hay aquellos que tienen niveles alarmantes de no susceptibilidad y, para los países más pobres, hay una falta de datos más completos, porque en aquellos con los niveles más preocupantes de no susceptibilidad, las cepas de Acinetobacter spp. ya están encontradas con fenotipo de resistencia a múltiples fármacos.

Citas

Amiri, S., Hammami, S., Amoura, K., Dekhil, M., & Boubaker, I. B.-B. (2017). Characterization of carbapenem resistant Acinetobacter baumannii isolated from intensive care units in two teaching hospitals from Algeria and Tunisia. Pan African Medical Journal, 28. https://doi.org/10.11604/pamj.2017.28.19.9713

Ayobami, O., Willrich, N., Suwono, B., Eckmanns, T., & Markwart, R. (2020). The epidemiology of carbapenem-non-susceptible Acinetobacter species in Europe: analysis of EARS-Net data from 2013 to 2017. Antimicrobial Resistance & Infection Control, 9(1), 89. https://doi.org/10.1186/s13756-020-00750-5

CDC. (2009). Guidance for control of infections with carbapenem-resistant or carbapenemase-producing Enterobacteriaceae in acute care facilities. MMWR. Morbidity and Mortality Weekly Report, 58(10), 256–260.

CLSI. (2020). CLSI AST News Update. CLSI. https://clsi.org/media/3486/clsi_astnewsupdate_january2020.pdf

Fleming Fund. (2021). Aims & Values. 2021. https://www.flemingfund.org/about-us/our-aims/

Goel, N., Wattal, C., Oberoi, J. K., Raveendran, R., Datta, S., & Prasad, K. J. (2011). Trend analysis of antimicrobial consumption and development of resistance in non-fermenters in a tertiary care hospital in Delhi, India. Journal of Antimicrobial Chemotherapy, 66(7), 1625–1630. https://doi.org/10.1093/jac/dkr167

Harbarth, S., Balkhy, H. H., Goossens, H., Jarlier, V., Kluytmans, J., Laxminarayan, R., Saam, M., Van Belkum, A., & Pittet, D. (2015). Antimicrobial resistance: one world, one fight! Antimicrobial Resistance and Infection Control, 4(1), 49. https://doi.org/10.1186/s13756-015-0091-2

Hawkey, P. M., & Livermore, D. M. (2012). Carbapenem antibiotics for serious infections. BMJ, 344(may31 1), e3236–e3236. https://doi.org/10.1136/bmj.e3236

Hsu, L.-Y., Tan, T.-Y., Tam, V. H., Kwa, A., Fisher, D. A., & Koh, T.-H. (2010). Surveillance and Correlation of Antibiotic Prescription and Resistance of Gram-Negative Bacteria in Singaporean Hospitals. Antimicrobial Agents and Chemotherapy, 54(3), 1173–1178. https://doi.org/10.1128/AAC.01076-09

Jaidane, N., Naas, T., Oueslati, S., Bernabeu, S., Boujaafar, N., Bouallegue, O., & Bonnin, R. A. (2018). Whole-genome sequencing of NDM-1-producing ST85 Acinetobacter baumannii isolates from Tunisia. International Journal of Antimicrobial Agents, 52(6), 916–921. https://doi.org/10.1016/j.ijantimicag.2018.05.017

Kritsotakis, E. I., Kontopidou, F., Astrinaki, E., Roumbelaki, M., Ioannidou, E., & Gikas, A. (2017). Prevalence, incidence burden, and clinical impact of healthcare-associated infections and antimicrobial resistance: a national prevalent cohort study in acute care hospitals in Greece. Infection and Drug Resistance, 10, 317–328. https://doi.org/10.2147/IDR.S147459

Laxminarayan, R., Duse, A., Wattal, C., Zaidi, A. K. M., Wertheim, H. F. L., Sumpradit, N., Vlieghe, E., Hara, G. L., Gould, I. M., Goossens, H., Greko, C., So, A. D., Bigdeli, M., Tomson, G., Woodhouse, W., Ombaka, E., Peralta, A. Q., Qamar, F. N., Mir, F., … Cars, O. (2013). Antibiotic resistance—the need for global solutions. The Lancet Infectious Diseases, 13(12), 1057–1098. https://doi.org/10.1016/S1473-3099(13)70318-9

LSHTM. (2016). AMR Surveillance in low- and middle-income settings. London School of Hygiene & Tropical Medicine. https://wellcomeopenresearch.s3.amazonaws.com/supplementary/12527/99f63366-743d-473c-b3ad-e96403e4ab3e.pdf

Mansour, W. (2018). Tunisian antibiotic resistance problems: three contexts but one health. African Health Sciences, 18(4), 1202. https://doi.org/10.4314/ahs.v18i4.41

Mayanskiy, N., Chebotar, I., Alyabieva, N., Kryzhanovskaya, O., Savinova, T., Turenok, A., Bocharova, Y., Lazareva, A., Polikarpova, S., & Karaseva, O. (2017). Emergence of the Uncommon Clone ST944/ST78 Carrying bla OXA-40-like and bla CTX-M-like Genes Among Carbapenem-Nonsusceptible Acinetobacter baumannii in Moscow, Russia. Microbial Drug Resistance, 23(7), 864–870. https://doi.org/10.1089/mdr.2016.0302

McGettigan, P., Roderick, P., Kadam, A., & Pollock, A. (2019). Threats to global antimicrobial resistance control: Centrally approved and unapproved antibiotic formulations sold in India. British Journal of Clinical Pharmacology, 85(1), 59–70. https://doi.org/10.1111/bcp.13503

Patel, G., & Bonomo, R. A. (2013). “Stormy waters ahead”: global emergence of carbapenemases. Frontiers in Microbiology, 4, 48. https://doi.org/10.3389/fmicb.2013.00048

Patino, C. M., & Ferreira, J. C. (2015). Confidence intervals: a useful statistical tool to estimate effect sizes in the real world. Jornal Brasileiro de Pneumologia, 41(6), 565–566. https://doi.org/10.1590/s1806-37562015000000314

Perez, F., Hujer, A. M., Hujer, K. M., Decker, B. K., Rather, P. N., & Bonomo, R. A. (2007). Global Challenge of Multidrug-Resistant Acinetobacter baumannii. Antimicrobial Agents and Chemotherapy, 51(10), 3471–3484. https://doi.org/10.1128/AAC.01464-06

Petrović, T., Uzunović, S., Barišić, I., Luxner, J., Grisold, A., Zarfel, G., Ibrahimagić, A., Jakovac, S., Slaćanac, D., & Bedenić, B. (2018). Arrival of carbapenem-hydrolyzing-oxacillinases in Acinetobacter baumannii in Bosnia and Herzegovina. Infection, Genetics and Evolution, 58, 192–198. https://doi.org/10.1016/j.meegid.2017.12.021

Sousa, D., Castelo-Corral, L., Gutierrez-Urbon, J.-M., Molina, F., Lopez-Calvino, B., Bou, G., & Llinares, P. (2013). Impact of ertapenem use on Pseudomonas aeruginosa and Acinetobacter baumannii imipenem susceptibility rates: collateral damage or positive effect on hospital ecology? Journal of Antimicrobial Chemotherapy, 68(8), 1917–1925. https://doi.org/10.1093/jac/dkt091

The Lancet. (2005). Stumbling around in the dark. Lancet (London, England), 365(9476), 1983. https://doi.org/10.1016/S0140-6736(05)66671-8

The World Bank. (2021). DataBank. The World Bank. https://databank.worldbank.org/home.aspx

Theuretzbacher, U. (2017). Global antimicrobial resistance in Gram-negative pathogens and clinical need. Current Opinion in Microbiology, 39, 106–112. https://doi.org/10.1016/j.mib.2017.10.028

UNDP. (2021). Human Development Report 2020. United Nations Development Programme (UNDP). http://hdr.undp.org/sites/default/files/hdr2020.pdf

United Nations. (2019). Follow-up to the political declaration of the high-level meeting of the General Assembly on antimicrobial resistance. United Nations. https://undocs.org/en/A/73/869

Van Boeckel, T. P., Gandra, S., Ashok, A., Caudron, Q., Grenfell, B. T., Levin, S. A., & Laxminarayan, R. (2014). Global antibiotic consumption 2000 to 2010: an analysis of national pharmaceutical sales data. The Lancet Infectious Diseases, 14(8), 742–750. https://doi.org/10.1016/S1473-3099(14)70780-7

WHO. (2015a). Global Action Plan: on Antimicrobial Resistance. WHO. https://apps.who.int/iris/bitstream/handle/10665/193736/9789241509763_eng.pdf?sequence=1

WHO. (2015b). Global Antimicrobial Resistance Surveillance System: Manual for Early Implementation. https://apps.who.int/iris/bitstream/handle/10665/188783/9789241549400_eng.pdf?sequence=1

WHO. (2015c). Global Antimicrobial Resistance Surveillance System: Manual for Early Implementation. WHO. https://apps.who.int/iris/bitstream/handle/10665/188783/9789241549400_eng.pdf?sequence=1

WHO. (2017). Global priority list of antibiotic-resistant bacteria to guide research, discovery, and development of new antibiotics. World Health Organization (WHO). https://www.who.int/medicines/publications/WHO-PPL-Short_Summary_25Feb-ET_NM_WHO.pdf

WHO. (2018). GLASS Early Implementation Report: 2016-2017. WHO. https://www.who.int/glass/resources/publications/early-implementation-report/en/

WHO. (2019). GLASS Early Implementation Report: 2017-2018. WHO. https://www.who.int/glass/resources/publications/early-implementation-report-2017-2018/en/

WHO. (2020). GLASS Early Implementation Report: 2020. WHO. https://www.who.int/glass/resources/publications/early-implementation-report-2020/en/

WHO. (2021). Global Antimicrobial Resistance Surveillance System (GLASS). WHO. https://www.who.int/glass/en/

Williams, J. D. (1999). Beta-lactamases and beta-lactamase inhibitors. International Journal of Antimicrobial Agents, 12 Suppl 1, S3-7; discussion S26-7. https://doi.org/10.1016/s0924-8579(99)00085-0

Xu, J., Sun, Z., Li, Y., & Zhou, Q. (2013). Surveillance and Correlation of Antibiotic Consumption and Resistance of Acinetobacter baumannii complex in a Tertiary Care Hospital in Northeast China, 2003–2011. International Journal of Environmental Research and Public Health, 10(4), 1462–1473. https://doi.org/10.3390/ijerph10041462

Publicado

22/12/2021

Cómo citar

ARAUJO, P. M.; BRAÚNA, C. da C.; LEMOS, S. C. L.; GOMES, D. M.; SANTOS, V. R. dos; SILVA, S. F. da; LOPES, L. da S. Resistencia a los carbapenémicos por Acinetobacter spp. reportado a GLASS según el nivel de ingresos de los países. Research, Society and Development, [S. l.], v. 10, n. 17, p. e116101724115, 2021. DOI: 10.33448/rsd-v10i17.24115. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/24115. Acesso em: 17 jul. 2024.

Número

Sección

Ciencias de la salud