Alternativas farmacológicas a base de hierbas para el tratamiento de las convulsiones: Revisión de patente
DOI:
https://doi.org/10.33448/rsd-v11i2.25940Palabras clave:
Plantas medicinales; Convulsiones; Epilepsia; Anticonvulsivo.Resumen
La epilepsia, una afección neurológica asociada con convulsiones recurrentes, afecta a alrededor de 70 millones de personas en todo el mundo y es responsable de los costos de salud. Las terapias farmacológicas actuales utilizadas para tratar la epilepsia tienen una eficacia baja y muchos efectos secundarios adversos. Además, también se puede encontrar resistencia a los medicamentos. La asociación de estos factores compromete considerablemente la atención farmacoterapéutica del paciente. Por lo tanto, los productos naturales derivados de plantas son alternativas terapéuticas prometedoras en la búsqueda de nuevas opciones terapéutica para tratar las crisis epilépticas. Así, la búsqueda se realizó en la base de datos de patentes más grande del mundo, Espacenet, en enero de 2021 y recopiló especies vegetales (extractos, aceites esenciales y compuestos vegetales aislados) con potencial efecto en las convulsiones, publicadas entre 2015 y 2020. En los últimos años, investigadores y compañías farmacéuticas han desarrollado varios métodos para la obtención de extractos, aceites esenciales y purificación de compuestos naturales, que han demostrado ser efectivos para el tratamiento de ataques epilépticos en modelos animales preclínicos. Estos hallazgos tienen un potencial prometedor para el tratamiento de la epilepsia, especialmente para el manejo de la resistencia a los medicamentos; sin embargo, estos informes se encuentran en sus primeras etapas y es necesario realizar más estudios para comercializar estos compuestos.
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Derechos de autor 2022 Lícia Tairiny Santos Pina; Adriana Gibara Guimarães; Laeza Alves Sampaio; Juliana Oliveira Guimarães; Thallita Kelly Rabelo; Flávia Medeiros Savi; Mairim Russo Serafini
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