Alternativas farmacológicas baseadas em plantas para o tratamento de convulsões: Uma revisão de patentes

Autores

DOI:

https://doi.org/10.33448/rsd-v11i2.25940

Palavras-chave:

Plantas medicinais; Convulsão; Epilepsia; Anticonvulsivante.

Resumo

A epilepsia, uma condição neurológica associada a crises recorrentes, afeta cerca de 70 milhões de pessoas em todo o mundo e é responsável por custos de saúde. As terapias medicamentosas atuais utilizadas para o tratamento da epilepsia têm baixa eficácia e muitos efeitos colaterais adversos. Além disso, a resistência aos medicamentos também pode ser encontrada. A associação desses fatores compromete consideravelmente os cuidados farmacoterapêuticos do paciente. Portanto, produtos naturais derivados de plantas são alternativas terapêuticas promissoras na busca de novas opções terapêuticas para o tratamento de crises epilépticas. Assim, a busca foi realizada na maior base de patentes do mundo, Espacenet, em janeiro de 2021 e compilou espécies vegetais (extratos, óleos essenciais e compostos vegetais isolados) com potencial efeito na convulsão, publicadas entre 2015 e 2020. Nos últimos anos, pesquisadores e empresas farmacêuticas desenvolveram diversos métodos para obtenção de extratos, óleos essenciais e purificação de compostos naturais, que se mostraram eficazes para o tratamento de crises epilépticas em modelos animais pré-clínicos. Esses achados apresentam potencial promissor para o tratamento da epilepsia, principalmente para o manejo de fármacos resistentes, porém, esses relatos estão em seus estágios iniciais e mais estudos precisam ser feitos para que esses compostos sejam comercializados.

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29/01/2022

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PINA, L. T. S.; GUIMARÃES, A. G.; SAMPAIO, L. A.; GUIMARÃES, J. O.; RABELO, T. K.; SAVI, F. M.; SERAFINI, M. R. Alternativas farmacológicas baseadas em plantas para o tratamento de convulsões: Uma revisão de patentes. Research, Society and Development, [S. l.], v. 11, n. 2, p. e40411225940, 2022. DOI: 10.33448/rsd-v11i2.25940. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/25940. Acesso em: 27 jul. 2024.

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Artigos de Revisão