Ozonoterapia en odontología: revisión sistemática de la literatura

Autores/as

DOI:

https://doi.org/10.33448/rsd-v11i4.27474

Palabras clave:

Ozono; Odontología; Diente; Dientes; Esmalte; Boca.

Resumen

El objetivo de este estudio fue realizar una revisión sistemática para evaluar los efectos de la ozonoterapia en odontología. Las bases de datos utilizadas fueron Pubmed, Embase, Web of Science y OpenGrey. La palabra clave: “Ozono” combinada con una de las siguientes palabras clave: “Odontología”, “Dientes”, “Diente”, “Esmalte” y “Boca” se utilizaron para realizar la búsqueda, solo se incluyeron ensayos clínicos aleatorizados. Se utilizó la herramienta ROB2.0 para evaluar el riesgo de sesgo. Se incluyeron 36 artículos, 7 se clasificaron como de bajo riesgo de sesgo, 17 como de riesgo incierto y 12 como de alto riesgo. La mayoría de los artículos mostraron buenos resultados en las más diversas áreas de la odontología y el ozono mostró una amplia aplicabilidad, pero la gran cantidad de artículos clasificados como de alto riesgo de sesgo o riesgo incierto puede ser un factor limitante en la evidencia encontrada. La ozonoterapia mostró resultados satisfactorios en su aplicación en odontología, sin embargo, debido a la gran cantidad de artículos con alto o incierto riesgo de sesgo, nuestra evidencia es limitada. Se necesitan más ensayos clínicos aleatorios para evaluar los beneficios reales de la ozonoterapia en odontología.

Citas

ABOZ - Associação Brasileira de Ozonioterapia - NOTA DE ESCLARECIMENTO SOBRE A OZONIOTERAPIA - Notícias - 2017). https://www.aboz.org.br/noticias/nota-de-esclarecimento-sobre-a-oz%20onioterapia/74/.

Aguiar, L. J. P., Báez, O. G., González, C. R. & Cepero, S. M. (2010). Ozonoterapia y electroestimulación en retinosis pigmentaria. Revista Cubana de Oftalmología, 23(1), 57-66. de http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0864-21762010000100006&lng=es&tlng=es.

Ajeti, N. N., Pustina-Krasniqi, T., & Apostolska, S. (2018). The Effect of Gaseous Ozone in Infected Root Canal. Open access Macedonian journal of medical sciences, 6(2), 389–396. doi.org/10.3889/oamjms.2018.102.

Al Habashneh, R., Alsalman, W., & Khader, Y. (2015). Ozone as an adjunct to conventional nonsurgical therapy in chronic periodontitis: a randomized controlled clinical trial. Journal of periodontal research, 50(1), 37–43. doi.org/10.1111/jre.12177.

Al-Omiri, M. K., Al Nazeh, A. A., Kielbassa, A. M., & Lynch, E. (2018). Randomized controlled clinical trial on bleaching sensitivity and whitening efficacy of hydrogen peroxide versus combinations of hydrogen peroxide and ozone. Scientific reports, 8(1), 2407. doi.org/10.1038/s41598-018-20878-0.

Al-Omiri, M. K., Hassan, R. S., AlZarea, B. K., & Lynch, E. (2016). Effects of combining ozone and hydrogren peroxide on tooth bleaching: A clinical study. Journal of dentistry, 53, p.88–93. doi.org/10.1016/j.jdent.2016.08.002.

Amaral, A., Medeiros, M., & Parada, A. (2013). Feridas não são doenças do corpo, são doenças da alma. https://www.revistasuninter.com/revistasaude/index.php/revista-praticas-interativas/article/view/249.

Atabek, D., & Oztas, N. (2011). Effectiveness of Ozone with or without the Additional Use of Remineralizing Solution on Non-Cavitated Fissure Carious Lesions in Permanent Molars. European journal of dentistry, 5(4), 393–399.

Buliés, C. J. C. E. (2005). Oxígeno-ozonoterapia como coadyuvante en el tratamiento de las infecciones óseas. Revista Cubana de Ortopedia y Traumatología, 19(1) http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0864-215X2005000100002&lng=es&tlng=es.

Celakil, T., Muric, A., Gökcen Roehlig, B., & Evlioglu, G. (2019). Management of pain in TMD patients: Bio-oxidative ozone therapy versus occlusal splints. Cranio the journal of craniomandibular practice, 37(2), 85–93. doi.org/10.1080/08869634.2017.1389506.

Chandra, S. P., Chandrasekhar, R., Uloopi, K. S., Vinay, C., & Kumar, N. M. (2014). Success of root fillings with zinc oxide-ozonated oil in primary molars: preliminary results. European archives of paediatric dentistry: official journal of the European Academy of Paediatric Dentistry, 15(3), 191–195. doi.org/10.1007/s40368-013-0094-8.

Conselho Federal de Odontologia. (Brasil). Portaria n° 702, de 13 de março de 2018. Inclusão da ozonioterapia, e de mais nove tratamentos, chamados de Práticas Integrativas e Complementares no Sistema Único de Saúde. Ministério da Saúde. https://bvsms.saude.gov.br/bvs/saudelegis/gm/2018/prt0702_22_03_2018.html.

Cosola, S., Giammarinaro, E., Genovesi, A. M., Pisante, R., Poli, G., Covani, U., & Marconcini, S. (2019). A short-term study of the effects of ozone irrigation in an orthodontic population with fixed appliances. European journal of paediatric dentistry, 20(1), 15–18. doi.org/10.23804/ejpd.2019.20.01.03.

Doğan, M., Ozdemir Doğan, D., Düger, C., Ozdemir Kol, I., Akpınar, A., Mutaf, B., & Akar, T. (2014). Effects of high-frequency bio-oxidative ozone therapy in temporomandibular disorder-related pain. Medical principles and practice: International journal of the Kuwait University, Health Science Centre, 23(6), 507–510. doi.org/10.1159/000365355.

Domb W. C. (2014). Ozone therapy in dentistry. A brief review for physicians. Interventional neuroradiology: Journal of peritherapeutic neuroradiology surgical procedures and related neurosciences, 20(5), 632–636. doi.org/10.15274/INR-2014-10083.

Gandhi, K.K., Cappetta, E.G. & Pavaskar, R. (2019). Effectiveness of the adjunctive use of ozone and chlorhexidine in patients with chronic periodontitis. BDJ Open 5, 17 doi.org/10.1038/s41405-019-0025-9.

Glória, J., Douglas-de-Oliveira, D. W., E Silva, L., Falci, S., & Dos Santos, C. (2020). Influence of ozonized water on pain, oedema, and trismus during impacted third molar surgery: a randomized, triple blind clinical trial. BMC oral health, 20(1), 41. doi.org/10.1186/s12903-020-1029-5.

Grocholewicz, K., Matkowska-Cichocka, G., Makowiecki, P., Droździk, A., Ey-Chmielewska, H., Dziewulska, A., Tomasik, M., Trybek, G., & Janiszewska-Olszowska, J. (2020). Effect of nano-hydroxyapatite and ozone on approximal initial caries: a randomized clinical trial. Scientific reports, 10(1), 11192. doi.org/10.1038/s41598-020-67885-8.

Hayakumo, S., Arakawa, S., Mano, Y., & Izumi, Y. (2013). Clinical and microbiological effects of ozone nano-bubble water irrigation as an adjunct to mechanical subgingival debridement in periodontitis patients in a randomized controlled trial. Clinical oral investigations, 17(2), 379–388. doi.org/10.1007/s00784-012-0711-7.

Isler, S. C., Uraz, A., Guler, B., Ozdemir, Y., Cula, S., & Cetiner, D. (2018). Effects of Laser Photobiomodulation and Ozone Therapy on Palatal Epithelial Wound Healing and Patient Morbidity. Photomedicine and laser surgery, 36(11), 571–580. doi.org/10.1089/pho.2018.4492.

Johansson, E., van Dijken, J. W., Karlsson, L., & Andersson-Wenckert, I. (2014). Treatment effect of ozone and fluoride varnish application on occlusal caries in primary molars: a 12-month study. Clinical oral investigations, 18(7), 1785–1792. doi.org/10.1007/s00784-013-1160-7.

Jorge, R. A., Rodríguez, Y.L., Rodríguez, A. C., & Ruiz, J. A.A. (2006). Producción científica sobre aplicaciones terapéuticas del ozono en el Web of Science. ACIMED, 14(1) de http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1024-94352006000100007&lng=es&tlng=es.

Kazancioglu, H. O., & Erisen, M. (2015). Comparison of Low-Level Laser Therapy versus Ozone Therapy in the Treatment of Oral Lichen Planus. Annals of dermatology, 27(5), 485–491. doi.org/10.5021/ad.2015.27.5.485.

Kazancioglu, H. O., Ezirganli, S., & Demirtas, N. (2014a). Comparison of the influence of ozone and laser therapies on pain, swelling, and trismus following impacted third-molar surgery. Lasers in medical science, 29(4), 1313–1319. doi.org/10.1007/s10103-013-1300-y.

Kazancioglu, H. O., Kurklu, E., & Ezirganli, S. (2014b). Effects of ozone therapy on pain, swelling, and trismus following third molar surgery. International journal of oral and maxillofacial surgery, 43(5), 644–648. doi.org/10.1016/j.ijom.2013.11.006.

Kist, S., Kollmuss, M., Jung, J., Schubert, S., Hickel, R., & Huth, K. C. (2017). Comparison of ozone gas and sodium hypochlorite/chlorhexidine two-visit disinfection protocols in treating apical periodontitis: a randomized controlled clinical trial. Clinical oral investigations, 21(4), 995–1005. doi.org/10.1007/s00784-016-1849-5.

Krunić, J., Stojanović, N., Đukić, L., Roganović, J., Popović, B., Simić, I., & Stojić, D. (2019). Clinical antibacterial effectiveness and biocompatibility of gaseous ozone after incomplete caries removal. Clinical oral investigations, 23(2), 785–792. doi.org/10.1007/s00784-018-2495-x.

Kshitish D, Laxman VK. The use of ozonated water and 0.2% chlorhexidine in the treatment of periodontitis patients: A clinical and microbiologic study. Indian J Dent Res 2010; 21:341-8.

Martins, A., Silva, J. T. da,Graciola, L., Fréz, A. R., Ruaro, J. A., & Marquetti, M. da G. K. (2012). Efeito bactericida do gerador de alta frequência na cultura de Staphylococcus aureus. Fisioterapia E Pesquisa, 19(2), 153-157. doi.org/10.1590/S1809-29502012000200011.

Matys, J., Jaszczak, E., Flieger, R., Kostrzewska-Kaminiarz, K., Grzech-Leśniak, K., & Dominiak, M. (2020). Effect of ozone and diode laser (635 nm) in reducing orthodontic pain in the maxillary arch-a randomized clinical controlled trial. Lasers in medical science, 35(2), 487–496. doi.org/10.1007/s10103-019-02896-0.

McKenna, D. F., Borzabadi-Farahani, A., & Lynch, E. (2013). The effect of subgingival ozone and/or hydrogen peroxide on the development of peri-implant mucositis: a double-blind randomized controlled trial. The International journal of oral & maxillofacial implants, 28(6), 1483–1489. doi.org/10.11607/jomi.3168.

Mese, M., Tok, Y. T., Kaya, S., & Akcay, M. (2020). Influence of ozone application in the stepwise excavation of primary molars: a randomized clinical trial. Clinical oral investigations, 24(10), 3529–3538. doi.org/10.1007/s00784-020-03223-6.

Moraschini, V., Kischinhevsky, I., Calasans-Maia, M. D., Shibli, J. A., Sartoretto, S. C., Figueredo, C. M., & Granjeiro, J. M. (2020). Ineffectiveness of ozone therapy in nonsurgical periodontal treatment: a systematic review and metaanalysis of randomized clinical trials. Clinical oral investigations, 24(6), 1877–1888. doi.org/10.1007/s00784-020-03289-2.

Mostafa, B., & Zakaria, M. (2018). Evaluation of Combined Topical Ozone and Steroid Therapy in Management of Oral Lichen Planus. Open access Macedonian journal of medical sciences, 6(5), 879–884. doi.org/10.3889/oamjms.2018.219.

Nicolini, A. C., Rotta, I., Langa, G., Friedrich, S. A., Arroyo-Bonilla, D. A., Wagner, M. C., Weidlich, P., Rösing, C. K., & Cavagni, J. (2021). Efficacy of ozonated water mouthwash on early plaque formation and gingival inflammation: a randomized controlled crossover clinical trial. Clinical oral investigations, 25(3), 1337–1344. doi.org/10.1007/s00784-020-03441-y.

Nogales, C. G., Ferrari, P. H., Kantorovich, E. O., & Lage-Marques, J. L. (2008). Ozone therapy in medicine and dentistry. The journal of contemporary dental practice, 9(4), 75–84.

Nuvolone, D., Petri, D., & Voller, F. (2018). The effects of ozone on human health. Environmental science and pollution research international, 25(9), 8074–8088. doi.org/10.1007/s11356-017-9239-3.

Oliveira, J. T. C. (2007). Revisão sistemática de literatura sobre o uso terapêutico do ozônio em feridas. Dissertação de Mestrado, Escola de Enfermagem, Universidade de São Paulo, São Paulo. doi:10.11606/D.7.2007.tde-20122007-094050. www.teses.usp.br.

Patel, P. V., Kumar, V., Kumar, S., Gd, V., & Patel, A. (2011). Therapeutic effect of topical ozonated oil on the epithelial healing of palatal wound sites: a planimetrical and cytological study. Journal of investigative and clinical dentistry, 2(4), 248–258. doi.org/10.1111/j.2041-1626.2011.00072.x.

Safwat, O., Elkateb, M., Dowidar, K., & El Meligy, O. (2017). Clinical Evaluation of Ozone on Dentinal Lesions in Young Permanent Molars using the Stepwise Excavation. The Journal of clinical pediatric dentistry, 41(6), 429–441. doi.org/10.17796/1053-4628-41.6.3.

Santos, G. M., Pacheco, R. L., Bussadori, S. K., Santos, E. M., Riera, R., Latorraca, C. O. C., Mota, P., Bellotto, E. F. B. C., & Martimbianco, A. L. C. (2020). Effectiveness and Safety of Ozone Therapy in Dental Caries Treatment: Systematic Review and Meta-analysis. The journal of evidence-based dental practice, 20(4), 101472. doi.org/10.1016/j.jebdp.2020.101472.

Seidler, V., Linetskiy, I., Hubálková, H., Stanková, H., Smucler, R., & Mazánek, J. (2008). Ozone and its usage in general medicine and dentistry. A review article. Prague medical report, 109(1), 5–13.

Seydanur Dengizek, E., Serkan, D., Abubekir, E., Aysun Bay, K., Onder, O., & Arife, C. (2019). Evaluating clinical and laboratory effects of ozone in non-surgical periodontal treatment: a randomized controlled trial. Journal of applied oral science, 27, e20180108. doi.org/10.1590/1678-7757-2018-0108.

Silva, E., Prado, M. C., Soares, D. N., Hecksher, F., Martins, J., & Fidalgo, T. (2020). The effect of ozone therapy in root canal disinfection: a systematic review. International endodontic journal, 53(3), 317–332. doi.org/10.1111/iej.13229.

Sivalingam, V. P., Panneerselvam, E., Raja, K. V., & Gopi, G. (2017). Does Topical Ozone Therapy Improve Patient Comfort After Surgical Removal of Impacted Mandibular Third Molar? A Randomized Controlled Trial. Journal of oral and maxillofacial surgery: Journal of the American Association of Oral and Maxillofacial Surgeons, 75(1), 51.e1–51.e9. doi.org/10.1016/j.joms.2016.09.014.

Skurska, A., Pietruska, M. D., Paniczko-Drężek, A., Dolińska, E., Zelazowska-Rutkowska, B., Zak, J., Pietruski, J., Milewski, R., & Wysocka, J. (2010). Evaluation of the influence of ozonotherapy on the clinical parameters and MMP levels in patients with chronic and aggressive periodontitis. Advances in medical sciences, 55(2), 297–307. doi.org/10.2478/v10039-010-0048-x.

Sridharan, K., & Sivaramakrishnan, G. (2021). Interventions for oral lichen planus: A systematic review and network meta-analysis of randomized clinical trials. Australian dental journal, 10.1111/adj.12835. Advance online publication. doi.org/10.1111/adj.12835.

Taşdemir, Z., Alkan, B. A., & Albayrak, H. (2016). Effects of Ozone Therapy on the Early Healing Period of Deepithelialized Gingival Grafts: A Randomized Placebo-Controlled Clinical Trial. Journal of periodontology, 87(6), 663–671. doi.org/10.1902/jop.2016.150217.

Tasdemir, Z., Oskaybas, M. N., Alkan, A. B., & Cakmak, O. (2019). The effects of ozone therapy on periodontal therapy: A randomized placebo-controlled clinical trial. Oral diseases, 25(4), 1195–1202. doi.org/10.1111/odi.13060.

Unal, M., & Oztas, N. (2015). Remineralization Capacity of Three Fissure Sealants with and without Gaseous Ozone on Non-Cavitated Incipient Pit and Fissure Caries. The Journal of clinical pediatric dentistry, 39(4), 364–370. doi.org/10.17796/1053-4628-39.4.364.

Uraz, A., Karaduman, B., Isler, S. Ç., Gönen, S., & Çetiner, D. (2019). Ozone application as adjunctive therapy in chronic periodontitis: Clinical, microbiological and biochemical aspects. Journal of dental sciences, 14(1), 27–37. doi.org/10.1016/j.jds.2018.06.005.

Vasthavi, C., Babu, H. M., Rangaraju, V. M., Dasappa, S., Jagadish, L., & Shivamurthy, R. (2020). Evaluation of ozone as an adjunct to scaling and root planing in the treatment of chronic periodontitis: A randomized clinico-microbial study. Journal of Indian Society of Periodontology, 24(1), 42–46. doi.org/10.4103/jisp.jisp_162_19.

Wang X. (2018). Emerging roles of ozone in skin diseases. Journal of Central South University, 43(2), 114–123. doi.org/10.11817/j.issn.1672-7347.2018.02.002.

Publicado

24/03/2022

Cómo citar

BASTOS, P. L.; OTTOBONI, G. S.; KARAM, A. M.; SAMPIERI, M. B. da S. .; ARAÚJO, E. F. de. Ozonoterapia en odontología: revisión sistemática de la literatura. Research, Society and Development, [S. l.], v. 11, n. 4, p. e46711427474, 2022. DOI: 10.33448/rsd-v11i4.27474. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/27474. Acesso em: 22 dic. 2024.

Número

Sección

Ciencias de la salud