El decanoato de nandrolona reduce los efectos positivos del entrenamiento de resistencia sobre la cognición, el comportamiento ansioso y la morfología del hipocampo en ratas
DOI:
https://doi.org/10.33448/rsd-v11i8.30600Palabras clave:
Memoria; Ejercicio físico; Testosterona; Hipertrofia; Conducta.Resumen
Los AAs se han vuelto populares entre los atletas competitivos y la población en general con fines recreativos y de rendimiento. El uso indiscriminado de AAs se produce en dosis suprafisiológicas y afecta negativamente a la cognición. Además, el abuso de decanoato de nandrolona (DECA) puede reducir los efectos beneficiosos del entrenamiento de resistencia (RT) en la salud. Objetivo: Se quiso investigar si la administración de DECA en dosis suprafisiológicas interfiere con los efectos positivos de la RT sobre el comportamiento, la memoria y la morfología de las neuronas en el hipocampo de las ratas. Materiales y métodos: Las ratas se distribuyeron aleatoriamente en cuatro grupos (N = 12): Control (C); DECA (D); Trenado (T) Trenado+DECA (TD). DECA AE se administró en dosis suprafisiológicas diarias de 15 mg/kg durante las 8 semanas del protocolo TR. Todos los grupos realizaron una prueba de carga máxima antes y después del protocolo TR; se realizaron pruebas de comportamiento ansioso y memoria, y luego las ratas fueron sacrificadas para el análisis morfológico del hipocampo. DECA produjo un efecto aniogénico, empeoró la cognición y redujo el grosor de la capa granulada de DG en el hipocampo. Además, DECA redujo los efectos positivos de TR en la cognición y las neuronas gd. Este es el primer estudio que muestra que las dosis suprafarmacológicas de DECA reducen los efectos positivos de TR sobre la memoria y el grosor de la capa granular de GD.
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Derechos de autor 2022 Caíque Olegário Diniz e Magalhães; Lucas Renan Sena de Oliveira; Stefanyne Teixeira Santos; Bruno Ferreira Mendes; Isabella Rocha Dias; Poliany Pereira Cruz ; Kinulpe Honorato Sampaio; Marco Fabrício Dias Peixoto; Ricardo Augusto Leoni de Sousa; Ricardo Cardoso Cassilhas
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