Terapia anticoagulante para el tratamiento del COVID-19 y su impacto en la cavidad oral: una revisión

Autores/as

DOI:

https://doi.org/10.33448/rsd-v11i9.32195

Palabras clave:

Covid-19; Anticoagulantes; Factores de riesgo.

Resumen

Fundamentos: A COVID-19 é uma doença inflamatória causó pelo SARS-CoV-2, na qual p paciente pode evoluir para um estado hipercoagulavel, necesitándose de terapia antitrombótica. Objetivos: Descrever dados da literatura sobre o uso de anticoagulantes como tratamiento para pacientes COVID-19 positivo y su repercussão na cavidade oral, os antiagregantes plaquetários e anticoagulantes utilizados para auxilio de tratamiento de pacientes COVID -positivo, os exames e marcadores que auxiliam a escolha da terapia a ser utilizada, así como observar o tratar y asociar ao riesgo de hemorragia oral. Metodología: Foi realizado um levantamiento bibliográfico no período de 2012 a 2021 na base de pesquisa BvSalud. Foram usó as palavras-chaves “ COVID ”, “anticoagulantes” e “fatores de risco” y seus correspondientes em inglês “ COVID ”, “anticoagulants e “riskfactors”. Results: Foram selecionados 128 artigos na BvSalud, após a leitura foram excluídos 68 artigos, restando 60 artigos that adentiam os critérios for revisão de literatura. Conclusión: A COVID -19 é uma patologia que age sobre os receptores ECA2, desencadeando uma resposta inflamatória e ativando a cascata de coagulação, exames hematológicos (D-dimero, fibrinogenio, ferritina, tempo de protrombina, interleucina-6 and Proteina-C- reativa) puede ser utilizado para evaluar o estado del paciente. Una decisión de iniciar una terapia anticoagulante o antiagregante deve ocorrer después de una evaluación de los marcadores. Tal terapia puede exacerbar sangramentos decorativos de traumas o no hay momento de intubação ou de úlceras preexistentes ou adquiridas después de admisión en UTI, una instalación do TET requiere cuidados especiales com a higiene oral del paciente, tendo em vista a maior susceptibilidade as infecções secundárias.

Citas

Abdelwahab, H. W., Shaltout, S. W., Sayed Ahmed, H. A., Fouad, A. M., Merrell, E., Riley, J. B., Salama, R., Abdelrahman, A. G., Darling, E., Fadel, G., Elfar, M. S. A., Sabry, K., Shah, J., Amin, H., Nieman, G. F., Mishriky, A., & Aiash, H. (2021). Acetylsalicylic Acid Compared with Enoxaparin for the Prevention of Thrombosis and Mechanical Ventilation in COVID-19 Patients: A Retrospective Cohort Study. Clinical Drug Investigation, 41(8), 723–732. https://doi.org/10.1007/s40261-021-01061-2

Al-Ani, F., Chehade, S., & Lazo-Langner, A. (2020). Thrombosis risk associated with COVID-19 infection. A scoping review. Thrombosis research, 192, 152–160. https://doi.org/10.1016/j.thromres.2020.05.039

Al-Bayaty, F. H., Baharudin, N., & Hassan, M. I. A. (2021). Impact of dental plaque control on the survival of ventilated patients severely affected by COVID-19 infection: An overview. Dental and Medical Problems, 58(3), 385–395. https://doi.org/10.17219/dmp/132979

Alijotas-Reig, J., Esteve-Valverde, E., Belizna, C., Selva-O’Callaghan, A., Pardos-Gea, J., Quintana, A., Mekinian, A., Anunciacion-Llunell, A., & Miró-Mur, F. (2020). Immunomodulatory therapy for the management of severe COVID-19. Beyond the anti-viral therapy: A comprehensive review. Autoimmunity Reviews, 19(7), 102569. https://doi.org/10.1016/j.autrev.2020.102569

Bikdeli, B., Madhavan, M. V., Jimenez, D., Chuich, T., Dreyfus, I., Driggin, E., Nigoghossian, C. D., Ageno, W., Madjid, M., Guo, Y., Tang, L. V., Hu, Y., Giri, J., Cushman, M., Quéré, I., Dimakakos, E. P., Gibson, C. M., Lippi, G., Favaloro, E. J., & Fareed, J. (2020). COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow-up. Journal of the American College of Cardiology, 75(23). https://doi.org/10.1016/j.jacc.2020.04.031

Bowsher, J., Boyle, S., & Griffiths, J. (n.d.). A review of the research evidence base for oral care procedures utilised by nurses A clinical effectiveness review. http://www.sigwales.org/wp-content/uploads/bowsher20boyle20griffiths201999.pdf

Brum, C. N., Zuge, S. S., Rangel, R. F., Freitas, H. M. B., & Pieszak, G. M (2015). Revisão narrativa da literatura: aspectos conceituais e metodológicos na construção do conhecimento da enfermagem. In: Lacerda, M. R., & Costenaro, R. G. S. Metodologias da pesquisa para a enfermagem e saúde. (1ª ed.): Moriá

Chocron, R., Duceau, B., Gendron, N., Ezzouhairi, N., Khider, L., Trimaille, A., Goudot, G., Weizman, O., Alsac, J. M., Pommier, T., Bory, O., Cellier, J., Philippe, A., Geneste, L., Ben Abdallah, I., Panagides, V., El Batti, S., Marsou, W., Juvin, P., Deney, A., Critical COVID-19 France investigators (2021). D-dimer at hospital admission for COVID-19 are associated with in-hospital mortality, independent of venous thromboembolism: Insights from a French multicenter cohort study. Archives of cardiovascular diseases, 114(5), 381–393. https://doi.org/10.1016/j.acvd.2021.02.003

Daughety, M. M., Morgan, A., Frost, E., Kao, C., Hwang, J., Tobin, R., Patel, B., Fuller, M., Welsby, I., & Ortel, T. L. (2020). COVID-19 associated coagulopathy: Thrombosis, hemorrhage and mortality rates with an escalated-dose thromboprophylaxis strategy. Thrombosis research, 196, 483–485. https://doi.org/10.1016/j.thromres.2020.10.004

Dogra, S., Jain, R., Cao, M., Bilaloglu, S., Zagzag, D., Hochman, S., Lewis, A., Melmed, K., Hochman, K., Horwitz, L., Galetta, S., & Berger, J. (2020). Hemorrhagic stroke and anticoagulation in COVID-19. Journal of Stroke and Cerebrovascular Diseases, 29(8). https://doi.org/10.1016/j.jstrokecerebrovasdis.2020.104984

Emmerich, J. (2020). Venous thromboembolism and COVID-19 patients: An ongoing story. JMV-Journal de Médecine Vasculaire. https://doi.org/10.1016/j.jdmv.2020.12.001

Franco, J. B., Ribas, P. F., Valente Júnior, L. A. S., Matias, D. T., Varotto, B. L. R., Hamza, C. R., Araújo, J. F., & Peres, M. P. S. de M. (2020). Hospital Dentistry and Dental Care for Patients with Special Needs: Dental approach during COVID-19 Pandemic. Brazilian Dental Science, 23(2). https://doi.org/10.14295/bds.2020.v23i2.2243

García-Ortega, A., Oscullo, G., Calvillo, P., López-Reyes, R., Méndez, R., Gómez-Olivas, J. D., Bekki, A., Fonfría, C., Trilles-Olaso, L., Zaldívar, E., Ferrando, A., Anguera, G., Briones-Gómez, A., Reig-Mezquida, J. P., Feced, L., González-Jiménez, P., Reyes, S., Muñoz-Núñez, C. F., Carreres, A., Gil, R., & Martínez-García, M. Á. (2021). Incidence, risk factors, and thrombotic load of pulmonary embolism in patients hospitalized for COVID-19 infection. The Journal of infection, 82(2), 261–269. https://doi.org/10.1016/j.jinf.2021.01.003

Giannis, D., Allen, S. L., Tsang, J., Flint, S., Pinhasov, T., Williams, S., Tan, G., Thakur, R., Leung, C., Snyder, M., Bhatia, C., Garrett, D., Cotte, C., Isaacs, S., Gugerty, E., Davidson, A., Marder, G. S., Schnitzer, A., Goldberg, B., McGinn, T., & Spyropoulos, A. C. (2021). Postdischarge thromboembolic outcomes and mortality of hospitalized patients with COVID-19: the CORE-19 registry. Blood, 137(20), 2838–2847. https://doi.org/10.1182/blood.2020010529

Gibson, C. M., Spyropoulos, A. C., Cohen, A. T., Hull, R. D., Goldhaber, S. Z., Yusen, R. D., Hernandez, A. F., Korjian, S., Daaboul, Y., Gold, A., Harrington, R. A., & Chi, G. (2017). The IMPROVEDD VTE Risk Score: Incorporation of D-Dimer into the IMPROVE Score to Improve Venous Thromboembolism Risk Stratification. TH open : companion journal to thrombosis and haemostasis, 1(1), e56–e65. https://doi.org/10.1055/s-0037-1603929

Godier, A., Clausse, D., Meslin, S., Bazine, M., Lang, E., Huche, F., Cholley, B., & Hamada, S. R. (2021). Major bleeding complications in critically ill patients with COVID-19 pneumonia. Journal of thrombosis and thrombolysis, 52(1), 18–21. https://doi.org/10.1007/s11239-021-02403-9

Görlinger, K., Dirkmann, D., Gandhi, A., & Simioni, P. (2020). COVID-19 associated coagulopathy and inflammatory response. Anesthesia & Analgesia, Publish Ahead of Print. https://doi.org/10.1213/ane.0000000000005147

Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., Cheng, Z., Yu, T., Xia, J., Wei, Y., Wu, W., Xie, X., Yin, W., Li, H., Liu, M., & Xiao, Y. (2020). Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet, 395(10223), 497–506. https://doi.org/10.1016/s0140-6736(20)30183-5

Iba, T., Nisio, M. D., Levy, J. H., Kitamura, N., & Thachil, J. (2017). New criteria for sepsis-induced coagulopathy (SIC) following the revised sepsis definition: a retrospective analysis of a nationwide survey. BMJ Open, 7(9), e017046. https://doi.org/10.1136/bmjopen-2017-017046

Ji, Y. L., Wu, Y., Qiu, Z., Ming, H., Zhang, Y., Zhang, A. N., Leng, Y., & Xia, Z. Y. (2021). The Pathogenesis and Treatment of COVID-19: A System Review. Biomedical and Environmental Sciences, 34(1), 50–60. https://doi.org/10.3967/bes2021.007

Jiménez, D., de Miguel-Díez, J., Guijarro, R., Trujillo-Santos, J., Otero, R., Barba, R., Muriel, A., Meyer, G., Yusen, R. D., & Monreal, M. (2016). Trends in the Management and Outcomes of Acute Pulmonary Embolism. Journal of the American College of Cardiology, 67(2), 162–170. https://doi.org/10.1016/j.jacc.2015.10.060

Kahn, S. R., Lim, W., Dunn, A. S., Cushman, M., Dentali, F., Akl, E. A., Cook, D. J., Balekian, A. A., Klein, R. C., Le, H., Schulman, S., & Murad, M. H. (2012). Prevention of VTE in nonsurgical patients: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest, 141(2 Suppl), e195S–e226S. https://doi.org/10.1378/chest.11-2296

Kaya, H., Turan, Y., Tunalı, Y., Aydın, G. Ö., Yüce, N., Gürbüz, Ş., & Tosun, K. (2017). Effects of oral care with glutamine in preventing ventilator-associated pneumonia in neurosurgical intensive care unit patients. Applied Nursing Research, 33, 10–14. https://doi.org/10.1016/j.apnr.2016.10.006

Kearon, C., Akl, E. A., Ornelas, J., Blaivas, A., Jimenez, D., Bounameaux, H., Huisman, M., King, C. S., Morris, T. A., Sood, N., Stevens, S. M., Vintch, J., Wells, P., Woller, S. C., & Moores, L. (2016). Antithrombotic Therapy for VTE Disease: CHEST Guideline and Expert Panel Report. Chest, 149(2), 315–352. https://doi.org/10.1016/j.chest.2015.11.026

Khan, I. H., Savarimuthu, S., Leung, M. S. T., & Harky, A. (2020). The need to manage the risk of thromboembolism in COVID-19 patients. Journal of Vascular Surgery, 72(3), 799–804. https://doi.org/10.1016/j.jvs.2020.05.015

Klok, F. A., Kruip, M., van der Meer, N., Arbous, M. S., Gommers, D., Kant, K. M., Kaptein, F., van Paassen, J., Stals, M., Huisman, M. V., & Endeman, H. (2020). Confirmation of the high cumulative incidence of thrombotic complications in critically ill ICU patients with COVID-19: An updated analysis. Thrombosis research, 191, 148–150. https://doi.org/10.1016/j.thromres.2020.04.041

Li, W., Xu, Z., Xiang, H., Zhang, C., Guo, Y., & Xiong, J. (2021). Risk factors for systemic and venous thromboembolism, mortality and bleeding risks in 1125 patients with COVID-19: relationship with anticoagulation status. Aging, 13(7), 9225–9242. https://doi.org/10.18632/aging.202769

Mant, M. J., O'Brien, B. D., Thong, K. L., Hammond, G. W., Birtwhistle, R. V., & Grace, M. G. (1977). Haemorrhagic complications of heparin therapy. Lancet (London, England), 1(8022), 1133–1135. https://doi.org/10.1016/s0140-6736(77)92388-1

Martin, T. A., Wan, D. W., Hajifathalian, K., Tewani, S., Shah, S. L., Mehta, A., Kaplan, A., Ghosh, G., Choi, A. J., Krisko, T. I., Fortune, B. E., Crawford, C. V., & Sharaiha, R. Z. (2020). Gastrointestinal Bleeding in Patients With Coronavirus Disease 2019: A Matched Case-Control Study. American Journal of Gastroenterology, 115(10), 1609–1616. https://doi.org/10.14309/ajg.0000000000000805

Miesbach, W., & Makris, M. (2020). COVID-19: Coagulopathy, Risk of Thrombosis, and the Rationale for Anticoagulation. Clinical and Applied Thrombosis/Hemostasis, 26, 107602962093814. https://doi.org/10.1177/1076029620938149

Moores, L. K., Tritschler, T., Brosnahan, S., Carrier, M., Collen, J. F., Doerschug, K., Holley, A. B., Jimenez, D., LeGal, G., Rali, P., & Wells, P. (2020). Prevention, Diagnosis, and Treatment of VTE in Patients With COVID-19. Chest. https://doi.org/10.1016/j.chest.2020.05.559

Moschonas, I. C., & Tselepis, A. D. (2021). SARS-CoV-2 infection and thrombotic complications: a narrative review. Journal of thrombosis and thrombolysis, 52(1), 111–123. https://doi.org/10.1007/s11239-020-02374-3

Mousavi, S., Moradi, M., Khorshidahmad, T., & Motamedi, M. (2015). Anti-Inflammatory Effects of Heparin and Its Derivatives: A Systematic Review. Advances in Pharmacological Sciences, 2015, 1–14. https://doi.org/10.1155/2015/507151

Ornelas-Ricardo, D., & Jaloma-Cruz, A. R. (2020). Coronavirus Disease 2019: Hematological Anomalies and Antithrombotic Therapy. The Tohoku journal of experimental medicine, 251(4), 327–336. https://doi.org/10.1620/tjem.251.327

Pancaldi, E., Pascariello, G., Cimino, G., Cersosimo, A., Amore, L., Alghisi, F., Bernardi, N., Calvi, E., Lombardi, C. M., Vizzardi, E., & Metra, M. (2021). Thrombotic risk in patients with COVID-19. Reviews in cardiovascular medicine, 22(2), 277–286. https://doi.org/10.31083/j.rcm2202035

Paranjpe, I., Fuster, V., Lala, A., Russak, A. J., Glicksberg, B. S., Levin, M. A., Charney, A. W., Narula, J., Fayad, Z. A., Bagiella, E., Zhao, S., & Nadkarni, G. N. (2020). Association of Treatment Dose Anticoagulation With In-Hospital Survival Among Hospitalized Patients With COVID-19. Journal of the American College of Cardiology, 76(1), 122–124. https://doi.org/10.1016/j.jacc.2020.05.001

Parks, A. L., Auerbach, A. D., Schnipper, J. L., Anstey, J. E., Sterken, D. G., Hecht, T. E. H., Fang, M. C., Vaughn, V. M., Dunn, A. S., Linker, A. S., Hunt, D. P., Choi, J. J., Brotman, D. J., Streiff, M. B., Mattison, M. L. P., Pappas, M. A., Greysen, S. R., Hemsey, D. F., Dapaah-Afriyie, K., & Ahuja, N. (2020). COVID-19 coagulopathy and thrombosis: Analysis of hospital protocols in response to the rapidly evolving pandemic. Thrombosis Research, 196, 355–358. https://doi.org/10.1016/j.thromres.2020.09.018

Piera Carbonell, A., Frías Vargas, M., García Vallejo, O., García Lerín, A., Cabrera Ferriols, M. A., Peiró Morant, J., & Carrasco Carrasco, E. (2020). COVID-19 y tromboprofilaxis: recomendaciones para nuestra práctica clínica en Atención Primaria. Semergen, 46(7), 479–486. https://doi.org/10.1016/j.semerg.2020.07.007

Porfidia, A., & Pola, R. (2020). Venous Thromboembolism and Heparin Use in COVID-19 Patients: Juggling between Pragmatic Choices, Suggestions of Medical Societies and the Lack of Guidelines. Journal of thrombosis and thrombolysis, 50(1), 68–71. https://doi.org/10.1007/s11239-020-02125-4

Schiaffino, S., Giacomazzi, F., Esseridou, A., Cozzi, A., Carriero, S., Mazzaccaro, D. P., Nano, G., Di Leo, G., Spagnolo, P., & Sardanelli, F. (2021). Pulmonary thromboembolism in coronavirus disease 2019 patients undergoing thromboprophylaxis. Medicine, 100(1), e24002. https://doi.org/10.1097/md.0000000000024002

Schulman, S., Hu, Y., & Konstantinides, S. (2020). Venous Thromboembolism in COVID-19. Thrombosis and Haemostasis. https://doi.org/10.1055/s-0040-1718532

Socransky, S. S., Haffajee, A. D., Cugini, M. A., Smith, C., & Kent, R. L. (1998). Microbial complexes in subgingival plaque. Journal of Clinical Periodontology, 25(2), 134–144. https://doi.org/10.1111/j.1600-051x.1998.tb02419.x

Stillson, J. E., Bunch, C. M., Gillespie, L., Khan, R., Wierman, M., Pulvirenti, J., Phyu, H., Anderson, S., Al-Fadhl, M., Thomas, A. V., Kwaan, H. C., Moore, E., Moore, H., & Walsh, M. M. (2021). Thromboelastography-Guided Management of Anticoagulated COVID-19 Patients to Prevent Hemorrhage. Seminars in Thrombosis and Hemostasis. https://doi.org/10.1055/s-0041-1723754

Tal, S., Spectre, G., Kornowski, R., & Perl, L. (2020). Venous Thromboembolism Complicated with COVID-19: What Do We Know So Far? Acta Haematologica, 1–8. https://doi.org/10.1159/000508233

Tang, N., Li, D., Wang, X., & Sun, Z. (2020). Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. Journal of Thrombosis and Haemostasis, 18(4), 844–847. https://doi.org/10.1111/jth.14768

Thachil, J., Tang, N., Gando, S., Falanga, A., Cattaneo, M., Levi, M., Clark, C., & Iba, T. (2020). ISTH interim guidance on recognition and management of coagulopathy in COVID-19. Journal of Thrombosis and Haemostasis. https://doi.org/10.1111/jth.14810

Topcu, A. C., Ozturk-Altunyurt, G., Akman, D., Batirel, A., & Demirhan, R. (2021). Acute Limb Ischemia in Hospitalized COVID-19 Patients. Annals of vascular surgery, 74, 88–94. https://doi.org/10.1016/j.avsg.2021.03.003

Vazquez, S. R. (2020). Vascular Disease Patient Information Page: Direct oral anticoagulants – 2020 update. Vascular Medicine, 25(2), 196–199. https://doi.org/10.1177/1358863x19898262

Wichmann, D., Sperhake, J. P., Lütgehetmann, M., Steurer, S., Edler, C., Heinemann, A., Heinrich, F., Mushumba, H., Kniep, I., Schröder, A. S., Burdelski, C., de Heer, G., Nierhaus, A., Frings, D., Pfefferle, S., Becker, H., Bredereke-Wiedling, H., de Weerth, A., Paschen, H. R., Sheikhzadeh-Eggers, S., & Kluge, S. (2020). Autopsy Findings and Venous Thromboembolism in Patients With COVID-19: A Prospective Cohort Study. Annals of internal medicine, 173(4), 268–277. https://doi.org/10.7326/M20-2003

Yin, S., Huang, M., Li, D., & Tang, N. (2020). Difference of coagulation features between severe pneumonia induced by SARS-CoV2 and non-SARS-CoV2. Journal of Thrombosis and Thrombolysis. https://doi.org/10.1007/s11239-020-02105-8

Zhang, J., Zhou, L., Yang, Y., Peng, W., Wang, W., & Chen, X. (2020). Therapeutic and triage strategies for 2019 novel coronavirus disease in fever clinics. The Lancet Respiratory Medicine, 8(3), e11–e12. https://doi.org/10.1016/S2213-2600(20)30071-0

Zhou, F., Yu, T., Du, R., Fan, G., Liu, Y., Liu, Z., Xiang, J., Wang, Y., Song, B., Gu, X., Guan, L., Wei, Y., Li, H., Wu, X., Xu, J., Tu, S., Zhang, Y., Chen, H., & Cao, B. (2020). Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. The Lancet, 395(10229), 1054–1062. https://doi.org/10.1016/s0140-6736(20)30566-3

Publicado

20/07/2022

Cómo citar

BARROS, I. A. de M. .; FERRAZ, G. D. M. G. .; CAVALCANTI , U. D. N. T. . Terapia anticoagulante para el tratamiento del COVID-19 y su impacto en la cavidad oral: una revisión. Research, Society and Development, [S. l.], v. 11, n. 9, p. e59611932195, 2022. DOI: 10.33448/rsd-v11i9.32195. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/32195. Acesso em: 22 dic. 2024.

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Ciencias de la salud