Efectos de la radioterapia en las condiciones bucales de los pacientes con câncer

Autores/as

DOI:

https://doi.org/10.33448/rsd-v11i9.32452

Palabras clave:

Cirujanos Dentistas; Radioterapia; Cáncer oral; Educación para la salud.

Resumen

Los tumores malignos de cabeza y cuello comprenden varios tipos de cáncer, incluidos principalmente el carcinoma de células escamosas y los tumores de la cavidad nasal, los senos paranasales, las glándulas salivales, la faringe y la laringe. Las tasas de supervivencia de HANC varían según el sitio del tumor. Las tasas de supervivencia a cinco años oscilan entre el 27,8 % para el cáncer de hipofaringe y el 67,0 % para el cáncer de glándulas salivales. En este contexto, este artículo tuvo como objetivo revisar la literatura sobre los efectos de la radioterapia en las condiciones orales de los pacientes con cáncer y abordar las estrategias de manejo oral para la radioterapia de cabeza y cuello. Para la construcción de este artículo se realizó un levantamiento bibliográfico en las bases de datos SciVerse Scopus, Scientific Electronic Library Online (Scielo), Estados Unidos. Biblioteca Nacional de Medicina (PUBMED) y ScienceDirect, utilizando el gestor de referencias de Mendeley. Los artículos fueron recolectados de febrero a julio de 2022 y abarcados entre los años 2015 a 2022. Los resultados de esta investigación revelan cuatro manifestaciones principales en la región oral de la radioterapia de cabeza y cuello, a saber, xerostomía, mucositis oral, osteorradionecrosis y trismus. Teniendo en cuenta las altas incidencias de PPC, es extremadamente importante que los profesionales de la salud estén familiarizados con las complicaciones derivadas de los tratamientos contra el cáncer.

Citas

Agarwal, P., Shiva Kumar, H. R., & Rai, K. K. (2016). Trismus in oral cancer patients undergoing surgery and radiotherapy. Journal of Oral Biology and Craniofacial Research, 6, S9–S13. https://doi.org/https://doi.org/10.1016/j.jobcr.2016.10.004

Binda, N. C., Binda, A. L. C., Rodrigues, S. de A., Loures, L. L. da S., Sá, A. C. S. F. de, Silva, J. V. L., Franco, A. G., Borba, T. O. da S., Magalhães, P. Í. B. M. de A., Araújo, E. L. da S. F. de, Souza, H. Y. M. S. de, Barbosa, R. L. S., Savi, F. da R., Reis, J. L., Ramalho, M. A., Fernandes, C. da S., & Sátiro, V. D. de S. (2021). Manifestações orais decorrentes da radioterapia de cabeça e pescoço. In Research, Society and Development. 10(12), e411101220519. https://doi.org/10.33448/rsd-v10i12.20519

Coelho, L. H. M., Silva, C. L. A., Pedra, R. C., Rosado, L. P. L., Verner, F. S., & Aquino, S. N. (2021). Probability of oral complications of radiotherapy and chemotherapy for head and neck cancer. General Dentistry, 69(4), 70–74.

Davies, A. N., & Thompson, J. (2015). Parasympathomimetic drugs for the treatment of salivary gland dysfunction due to radiotherapy. Cochrane Database of Systematic Reviews, 2015(10). https://doi.org/10.1002/14651858.CD003782.pub3

Davis, D. D., Hanley, M. E., & Cooper, J. S. (2022). Osteoradionecrosis.

Elting, L. S., Cooksley, C. D., Chambers, M. S., & Garden, A. S. (2007). Risk, outcomes, and costs of radiation-induced oral mucositis among patients with head-and-neck malignancies. International Journal of Radiation Oncology, Biology, Physics, 68(4), 1110–1120. https://doi.org/10.1016/j.ijrobp.2007.01.053

Ferretti, G. A., Raybould, T. P., Brown, A. T., Macdonald, J. S., Greenwood, M., Maruyama, Y., Geil, J., Lillich, T. T., & Ash, R. C. (1990). Chlorhexidine prophylaxis for chemotherapy- and radiotherapy-induced stomatitis: a randomized double-blind trial. Oral Surgery, Oral Medicine, and Oral Pathology, 69(3), 331–338. https://doi.org/10.1016/0030-4220(90)90295-4

Frankart, A. J., Frankart, M. J., Cervenka, B., Tang, A. L., Krishnan, D. G., & Takiar, V. (2021). Osteoradionecrosis: Exposing the Evidence Not the Bone. International Journal of Radiation Oncology*Biology*Physics, 109(5), 1206–1218. https://doi.org/https://doi.org/10.1016/j.ijrobp.2020.12.043

Gunn, L., Gilbert, J., Nenclares, P., Soliman, H., Newbold, K., Bhide, S., Wong, K. H., Harrington, K., & Nutting, C. (2021). Taste dysfunction following radiotherapy to the head and neck: A systematic review. Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology, 157, 130–140. https://doi.org/10.1016/j.radonc.2021.01.021

Hamilton, S. N., Tran, E., Ho, C., Berthelet, E., Wu, J., DeVries, K., LaPointe, V., Bowman, A., Lagman, M., & Olson, R. (2021). Patient-reported outcome measures in patients undergoing radiotherapy for head and neck cancer. Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer, 29(5), 2537–2547. https://doi.org/10.1007/s00520-020-05778-2

Haroun, K., & Coblens, O. M. (2019). Reconstruction of the mandible for osteoradionecrosis. Current Opinion in Otolaryngology & Head and Neck Surgery, 27(5), 401–406. https://doi.org/10.1097/MOO.0000000000000571

Kawashita, Y., Soutome, S., Umeda, M., & Saito, T. (2020). Oral management strategies for radiotherapy of head and neck cancer. Japanese Dental Science Review, 56(1), 62–67. https://doi.org/https://doi.org/10.1016/j.jdsr.2020.02.001

Kwon, Y. (2016). Mechanism-based management for mucositis: option for treating side effects without compromising the efficacy of cancer therapy. OncoTargets and Therapy, 9, 2007–2016. https://doi.org/10.2147/OTT.S96899

Lee, C. T., & Galloway, T. J. (2022). Pathogenesis and Amelioration of Radiation-Induced Oral Mucositis. Current Treatment Options in Oncology, 23(3), 311–324. https://doi.org/10.1007/s11864-022-00959-z

Leonetti, J. P., Weishaar, J. R., Gannon, D., Harmon, G. A., Block, A., & Anderson, D. E. (2020). Osteoradionecrosis of the skull base. Journal of Neuro-Oncology, 150(3), 477–482. https://doi.org/10.1007/s11060-020-03462-3

Li, E., & Trovato, J. A. (2012). New developments in management of oral mucositis in patients with head and neck cancer or receiving targeted anticancer therapies. American Journal of Health-System Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists, 69(12), 1031–1037. https://doi.org/10.2146/ajhp100531

Li, R., Su, L., Hua, Y., Ye, J.-R., Song, X.-R., Tian, J., Song, J.-H., & Hong, J.-S. (2021). Anxiety and depression status prior to radiotherapy in patients with nasopharyngeal carcinoma and its effect on acute radiation toxicities. European Journal of Cancer Care, 30(6), e13487. https://doi.org/10.1111/ecc.13487

Martins, A. F. L., Nogueira, T. E., Morais, M. O., Oton-Leite, A. F., Valadares, M. C., Batista, A. C., Freitas, N. M. A., Leles, C. R., & Mendonça, E. F. (2019). Effect of photobiomodulation on the severity of oral mucositis and molecular changes in head and neck cancer patients undergoing radiotherapy: a study protocol for a cost-effectiveness randomized clinical trial. Trials, 20(1), 97. https://doi.org/10.1186/s13063-019-3196-8

Moore, C., McLister, C., Cardwell, C., O’Neill, C., Donnelly, M., & McKenna, G. (2020). Dental caries following radiotherapy for head and neck cancer: A systematic review. Oral Oncology, 100, 104484. https://doi.org/https://doi.org/10.1016/j.oraloncology.2019.104484

Mortazavi, H., Shafiei, S., Sadr, S., & Safiaghdam, H. (2018). Drug-related Dysgeusia: A Systematic Review. Oral Health & Preventive Dentistry, 16(6), 499–507. https://doi.org/10.3290/j.ohpd.a41655

Muñoz-Corcuera, M., González-Nieto, A., & López-Pintor Muñoz, R. M. (2014). [Use of laser for the prevention and treatment of oral mucositis induced by radiotherapy and chemotherapy for head and neck cancer]. Medicina clinica, 143(4), 170–175. https://doi.org/10.1016/j.medcli.2013.09.017

Oladega, A., Mojdami, D., Hope, A., Watson, E., & Glogauer, M. (2021). The process of developing consensus guidelines by Dental Oncologists for pre-radiotherapy dental care in head and neck cancer patients using the modified Delphi technique. Journal of Evidence Based Dental Practice, 101620. https://doi.org/https://doi.org/10.1016/j.jebdp.2021.101620

Pereira, A., Shitsuka, D., Parreira, F., & Shitsuka, R. (2018). Método Qualitativo, Quantitativo ou Quali-Quanti. In Metodologia da Pesquisa Científica. https://repositorio.ufsm.br/bitstream/handle/1/15824/Lic_Computacao_Metodologia-Pesquisa-Cientifica.pdf?sequence=1. Acesso em: 28 março 2020.

Ribeiro, G. H., Chrun, E. S., Dutra, K. L., Daniel, F. I., & Grando, L. J. (2018). Osteonecrosis of the jaws: a review and update in etiology and treatment. Brazilian Journal of Otorhinolaryngology, 84(1), 102–108. https://doi.org/10.1016/j.bjorl.2017.05.008

Rivero, J. A., Shamji, O., & Kolokythas, A. (2017). Osteoradionecrosis: a review of pathophysiology, prevention and pharmacologic management using pentoxifylline, α-tocopherol, and clodronate. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 124(5), 464–471. https://doi.org/10.1016/j.oooo.2017.08.004

Scherpenhuizen, A., van Waes, A. M. A., Janssen, L. M., Van Cann, E. M., & Stegeman, I. (2015). The effect of exercise therapy in head and neck cancer patients in the treatment of radiotherapy-induced trismus: A systematic review. Oral Oncology, 51(8), 745–750. https://doi.org/https://doi.org/10.1016/j.oraloncology.2015.05.001

Sroussi, H. Y., Epstein, J. B., Bensadoun, R.-J., Saunders, D. P., Lalla, R. V, Migliorati, C. A., Heaivilin, N., & Zumsteg, Z. S. (2017). Common oral complications of head and neck cancer radiation therapy: mucositis, infections, saliva change, fibrosis, sensory dysfunctions, dental caries, periodontal disease, and osteoradionecrosis. Cancer Medicine, 6(12), 2918–2931. https://doi.org/10.1002/cam4.1221

Thakkar, J. P., & Lane, C. J. (2022). Hyposalivation and Xerostomia and Burning Mouth Syndrome: Medical Management. Oral and Maxillofacial Surgery Clinics of North America, 34(1), 135–146. https://doi.org/https://doi.org/10.1016/j.coms.2021.08.002

Vahidi, N., Lee, T. S., Daggumati, S., Shokri, T., Wang, W., & Ducic, Y. (2020). Osteoradionecrosis of the Midface and Mandible: Pathogenesis and Management. Seminars in Plastic Surgery, 34(4), 232–244. https://doi.org/10.1055/s-0040-1721759

Vélez, I., Tamara, L. A., & Mintz, S. (2004). Management of oral mucositis induced by chemotherapy and radiotherapy: an update. Quintessence International (Berlin, Germany : 1985), 35(2), 129–136.

Y, K., S, H., M, F., M, U., & T, S. (2014). Prophylactic bundle for radiation-induced oral mucositis in oral or oropharyngeal cancer patients. Journal of Cancer Research & Therapy, 2(1), 9–13. https://doi.org/10.14312/2052-4994.2014-2

Zhu, J., Zhang, H., Li, J., Zheng, X., Jia, X., Xie, Q., Zheng, L., Zhou, X., Wang, Y., & Xu, X. (2021). LiCl Promotes Recovery of Radiation-Induced Oral Mucositis and Dysgeusia. Journal of Dental Research, 100(7), 754–763. https://doi.org/10.1177/0022034521994756

Publicado

18/07/2022

Cómo citar

BOMFIM, R. M.; SANTANA, L. D. A. .; RODRIGUES , M. C.; CARNEIRO , G. K. M. .; ARAGÃO, F. A. A.; SANTOS, M. G. dos .; TORRE, M. V. A. D. .; NASCIMENTO NETO, E. V. do .; SILVA, A. C. R. da .; CARPINE, M. B. . Efectos de la radioterapia en las condiciones bucales de los pacientes con câncer. Research, Society and Development, [S. l.], v. 11, n. 9, p. e55311932452, 2022. DOI: 10.33448/rsd-v11i9.32452. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/32452. Acesso em: 3 jul. 2024.

Número

Sección

Ciencias de la salud