Efecto antibacteriano y liberación de tetraciclinas de matrices de poli(Ɛ-caprolactona) obtenidas por polimerización con yodo
DOI:
https://doi.org/10.33448/rsd-v11i9.32939Palabras clave:
Poli (ε-caprolactona); Polímero bioabsorbible; Administración de fármacos; Actividad antimicrobiana.Resumen
El desarrollo de dispositivos para la liberación controlada de fármacos está en constante innovación tecnológica. El objetivo es mejorar la liberación de fármacos en las áreas objetivo. La poli(ε-caprolactona) (PCL) ha sido ampliamente investigada debido a su tasa de degradación, biocompatibilidad, disponibilidad, ausencia de toxicidad, costo y buena adhesión a una gran cantidad de fármacos. Por lo tanto, en el presente estudio se asoció el polímero PCL con los antibióticos tetraciclina como sistema de administración local. La PCL se obtuvo mediante polimerización con apertura de anillo del monómero Ɛ-caprolactona (Ɛ-CL). Las muestras se caracterizaron por infrarrojo transformado de Fourier (FTIR), análisis calorimétrico diferencial de barrido (DSC), análisis termogravimétrico (TGA) y análisis de difracción de rayos X (rayos X). Asimismo, se investigó la actividad antimicrobiana frente a bacterias grampositivas (S. aureus) y gramnegativas (E. coli, P. mirabilis, P. aeruginosa y K. pneumoniae). Según los resultados, el antibiótico tetraciclina se ha incorporado con éxito a las matrices de PCL. Liberan tetraciclina en las tasas ideales y muestran actividad antibacteriana. Por lo tanto, este material tiene potencial para ser utilizado en implantes para la liberación de fármacos.
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Derechos de autor 2022 Lidiane Gomes da Silva; Amanda de Carvalho Pereira Moraes; Patrícia Capellato; Gilza Carla Ribeiro; Ana Angélica Martins Costa; Álvaro Antônio Alencar de Queiroz; Daniela Sachs
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