Efeito antibacteriano e liberação de tetraciclina de matrizes de poli(Ɛ-caprolactona) obtidas por polimerização de iodo
DOI:
https://doi.org/10.33448/rsd-v11i9.32939Palavras-chave:
Poli(ε-caprolactona); Polímero bioabsorvível; Drug delivery; Atividade antimicroba.Resumo
O desenvolvimento de dispositivos para controle da liberação de medicamentos está em constante inovação tecnológica. O objetivo é melhorar a liberação de medicamentos nas áreas-alvo. A poli(ε-caprolactona) (PCL) tem sido amplamente investigada devido à taxa de degradação, biocompatibilidade, disponibilidade, ausência de toxicidade, custo e boa adesão a um grande número de fármacos. Assim, no presente estudo foi associado o polímero PCL com o antibiótico tetraciclina como sistema de liberação local. PCL foi obtido por polimerização por abertura de anel do monômero Ɛ-caprolactona (Ɛ-CL). As amostras foram caracterizadas por infravermelho transformado de Fourier (FTIR), calorimetria de varredura diferencial (DSC), análise termogravimétrica (TGA) e análise de difração de raios-X (raios-X). Da mesma forma, foi investigada a atividade antimicrobiana contra bactérias gram-positivas (S. aureus) e bactérias gram-negativas (E. coli, P. mirabilis, P. aeruginosa e K. pneumoniae). De acordo com os resultados, o antibiótico tetraciclina foi incorporado com sucesso às matrizes PCL. Liberam tetraciclina nas taxas ideais e apresentam atividade antibacteriana. Assim, este material tem potencial para ser utilizado em implantes para liberação de fármacos.
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Copyright (c) 2022 Lidiane Gomes da Silva; Amanda de Carvalho Pereira Moraes; Patrícia Capellato; Gilza Carla Ribeiro; Ana Angélica Martins Costa; Álvaro Antônio Alencar de Queiroz; Daniela Sachs
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