Antimutagenic effects of copaiba oils (Copaifera langsdorffii Desf.) and flaxseed (Linum usitatissimum L.) against the clastogen – cyclophosphamide, in Wistar rat

Michele Cristina Heck; Mariana Yoshimoto-Higaki; Mariane Aparecida Franco de  Godoy; Debora Elisa Antunes de  Mendonça; Veronica Elisa Pimenta Vicentini

doi:10.33448/rsd-v11i11.33539

Autores/as

Michele Cristina Heck Universidade Estadual de Maringá https://orcid.org/0000-0002-5869-5007
Mariana Yoshimoto-Higaki State University of Maringá https://orcid.org/0000-0002-5748-5980
Mariane Aparecida Franco de Godoy State University of Maringá https://orcid.org/0000-0003-4186-5855
Debora Elisa Antunes de Mendonça State University of Maringá https://orcid.org/0000-0001-5733-996X
Veronica Elisa Pimenta Vicentini State University of Maringá https://orcid.org/0000-0003-1385-0058

DOI:

https://doi.org/10.33448/rsd-v11i11.33539

Palabras clave:

Plantas medicinales; Comida funcional; Citotoxicidad; Alteración cromosómica.

Resumen

Aceite de copaiba extraído del tronco de Copaifera langsdorffii Desf. y el aceite de linaza extraído de las semillas de Linum usitatissimum L., son ampliamente utilizados para la prevención y tratamiento de diversas enfermedades, entre ellas el cáncer. El objetivo de este estudio fue evaluar el efecto antimutagénico de estos aceites contra el agente inductor de daño ciclofosfamida, en Rattus norvegicus tratados in vivo por sonda, mediante ensayos de citotoxicidad y alteración cromosómica. Los animales fueron sometidos a una dosis única de aceite de copaiba y aceite de linaza en el tratamiento simultáneo, pretratamiento y postratamiento durante 24 horas. Ninguno de estos tratamientos mostró un efecto citotóxico. Los tratamientos con aceites asociados a ciclofosfamida redujeron significativamente el daño cromosómico causado por el clastógeno. En los grupos tratados con aceite de copaiba, el porcentaje de reducción fue del 77% para el tratamiento simultáneo, del 83% para el pretratamiento y del 75% para el postratamiento, mientras que en los tratados con aceite de linaza fue del 94% para el pretratamiento y 96% para tratamiento simultáneo y post-tratamiento. Estos resultados indican que ambos aceites no son mutagénicos, por el contrario, tienen actividad antimutagénica frente a este agente clastogénico, lo que representa un efecto protector de las células frente al fármaco que dañó el material genético.

Citas

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Efecto antimutagénico de los aceites de copaiba (Copaifera langsdorffii Desf.) y linaza (Linum usitatissimum L.) frente a la clastogénica – ciclofosfamida, en ratas Wistar

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