Expresión génica de factores de virulencia de Corynebacterium pseudotuberculosis y su papel en la patogenia de la linfadenitis caseosa
DOI:
https://doi.org/10.33448/rsd-v11i14.36061Palabras clave:
Corynebacterium pseudotuberculosis; Factores de virulência; Inmunidad.Resumen
Corynebacterium pseudotuberculosis es el agente causal de la linfadenitis caseosa (LC), una enfermedad infecciosa, granulomatosa, crónica y debilitante que afecta a varios animales, incluidos caprinos, ovinos, bovinos, equinos, camélidos y, más raramente, humanos. El grupo denominado CMNR, compuesto por bacterias de los géneros Corynebacterium, Mycobacterium, Nocardia y Rhodococcus, está involucrado en varias patologías importantes, tanto en medicina humana como veterinaria. El enfoque de los estudios con el agente etiológico de CL ha estado relacionado con el diagnóstico, la epidemiología, la profilaxis, la terapia y la genómica. Aunque la enfermedad ha sido estudiada desde principios del siglo XX, al igual que las causadas por otras entidades bacterianas, el estudio sobre la fisiopatología y los mecanismos de evasión de este agente son prácticamente desconocidos. Los factores de virulencia del agente etiológico de la linfadenitis caseosa son pocos, pero la secuenciación pionera del genoma de una cepa aislada de un paciente humano, C. pseudotuberculosis FRC41, permitió identificar y anotar varios genes codificadores de proteínas cuyas características fisiológicas coinciden con la definición del factor de virulencia. En Mycobacterium tuberculosis, la cinasa PknG controla el metabolismo de la glutamina, pero puede secretarse en fagosomas de macrófagos, lo que interfiere con la maduración de estos orgánulos. La misma enzima existe en otros representantes del suborden Corynebacterineae, incluido Corynebacterium pseudotuberculosis, ya se han descrito otros antígenos y se están dilucidando. En este contexto, el objetivo de este trabajo fue realizar una revisión sobre los factores de virulencia de C. pseudotuberculosis.
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Derechos de autor 2022 Jefferson Ivan Corrêa; José Tadeu Raynal Rocha Filho; Bruno Lopes Bastos; Daniel Menezes Bonaspetti; Júlia Maria Guimarães Matos; Ezequiel Fabiane Spanholi; Antonio Pedro Fróes de Farias; Lília Ferreira de Moura-Costa; Soraya Castro Trindade; Roberto José Meyer Nascimento
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